DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and kmt2ca

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:XP_005162602.1 Gene:kmt2ca / 560793 ZFINID:ZDB-GENE-080520-3 Length:4958 Species:Danio rerio


Alignment Length:2049 Identity:485/2049 - (23%)
Similarity:710/2049 - (34%) Gaps:770/2049 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 KVCCLCNLGEKSALGQGEILQLKAPAP-------------AEIKDKY--------PTDRLREDGS 71
            |:|..|..||||.||||| |:|..|.|             :|..|.|        ..|..|..|.
Zfish   142 KLCAFCYCGEKSLLGQGE-LKLFGPTPGYVPLHIRNRRGSSEKDDDYHDDDNDFDDNDNNRSPGH 205

  Fly    72 RLLYGPKQAASSSGDCHY--------------------ELDKIGQPDVVHPAEFLD-EGFVYVHR 115
            | ..|.|:.:|.....|.                    ||.:||.||.::.|...| .|....|.
Zfish   206 R-GSGLKKVSSPDSGLHSTSAPGSTDPAAEEPGRKFWDELGQIGLPDEINVAFLFDPTGQCCAHL 269

  Fly   116 MCIMWSLRKSQISDADG---AYFATHFAEFLEQKCNFCGRYGASIN-CKMNCRQVHHWPCAAAAG 176
            .|..||   ..:...:|   .|..........:.|.:|.|.||||. |:.:|.:..|:|||||||
Zfish   270 RCAAWS---EGVCRGEGQSLLYVDKAIDSGSTECCAYCKRLGASIKCCEESCGRSFHYPCAAAAG 331

  Fly   177 CLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSLGDLSKLIMCSTCGDHFHSTCIGLANLPDT 241
            ....::::|:.|.:::.|. ::.|.:.|:||.|.|.|||...:.|.|||.|:|.||:.:...|..
Zfish   332 TFQDIKTYTLLCPDYIQQA-LVRSKDGVKCLVCDSSGDLLDQLFCCTCGQHYHGTCLDVTVTPLK 395

  Fly   242 RSGWNCARCTKCQICRQQDSNDTKYVKCEQCQKTYHASCLRPVISAIPKYGWKCNRCRVCTDCGS 306
            |:||.|..|..|..|: ...:|:|.:.|:.|.|.||..||:|::..||..||:|..||.|..||.
Zfish   396 RAGWQCPECKVCLSCK-NPGDDSKMLVCDMCDKGYHTFCLQPIMETIPTNGWRCKNCRTCAQCGM 459

  Fly   307 RTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPICQKAYRAASHKEMVKCSWCNKFVHSTCDEEAD 371
            | |.|    :|.|:..:|:.|.||......|.||.::..:.|..:...|..|.::||..|     
Zfish   460 R-PNG----QWSSNGVMCEGCQQQHESALLCLICGQSQDSGSPADKHTCCTCKRWVHVDC----- 514

  Fly   372 LTAYHKKKEQNPDYD----YVCPNCK-----SNSSGPGSSQQ----------------------- 404
                .:::..|||..    |.|..||     :..|.|.|||:                       
Zfish   515 ----VRQEGTNPDTQLQDGYTCRACKQVEEETRHSQPVSSQEASLTDPEPAEDVFMSVEEVQEAE 575

  Fly   405 ---------------------------------TI------------------------------ 406
                                             |:                              
Zfish   576 GEVVLEPEPSASPLATLPDNFLSSTEPAQEIQVTVTLTEGPDPPPCSSTAVGVSSFSFQASTTTE 640

  Fly   407 ----DSIVLSAMDS------------------------------------------------SSE 419
                :|.::.|::.                                                ||:
Zfish   641 DHIQESSLIGALEMGKESEDKLPETTEEEPEPNVSKALPALPTKETSPMHTLAQEEEPMDVYSSD 705

  Fly   420 QLSLK---------------------------------EIELDPL--EGKPTMD----------- 438
            ..|:|                                 |.|..||  |..|||:           
Zfish   706 PYSMKDKRMTEAAVEDPEQKQEHEKPEVPDPEVTSIIPEPESVPLIPESSPTMEMDTTPVSERSF 770

  Fly   439 --------------------------------------PSSDELHKLPT---------------- 449
                                                  |.....::.||                
Zfish   771 SSFSSPVEDKCLVLKHSPGLSSEGSIKLTQSPFSTEASPRGSSQNQTPTHGLNAAGFSPNVSNTT 835

  Fly   450 ---------------GKKKVCLTSVRGRSGKFV-------------------------LH----- 469
                           .|:|......|.:.|.::                         :|     
Zfish   836 FFPLTPKIGMGKPAISKRKFSPGRPRVKQGAWINRSAMSSPSWSPERSDAWDSPKTRPMHGLPVW 900

  Fly   470 --RMGVMSQINKKRSTR--------GKGRQ--------LALPTIS-SDRCLSRSMETDLTSDKKL 515
              |:|..|....:|..|        |:||.        :..|.:| .|.......|.:.:....:
Zfish   901 TMRLGRGSGFPGRRRPRGANLSGRGGRGRSRLKMESSPVVTPGLSFLDSPYVVKEEEENSMHNTV 965

  Fly   516 LLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTV 580
            ::.|..|.|...||:||:|||.|..::..:::|:||||||||:|..:|.::.:|.||||||:|||
Zfish   966 VMFSTSDSFTLKQDMCVVCGSFGRGAEGRLLSCSQCGQCYHPFCVNIKITKVVLSKGWRCLECTV 1030

  Fly   581 CEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCG-RNPTEKSEFGDS 644
            ||.||:.:|..||||||:||||||.||::|||:.||.|:|||.:|.||..|| .:|..:.|: .:
Zfish  1031 CEACGQASDPGRLLLCDDCDISYHTYCLDPPLQNVPKGSWKCKWCVLCTHCGATSPGLRCEW-QN 1094

  Fly   645 NMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKCRC 709
            |..:|..|.|.:.||||..||...|:|:||..|:.|.|..|..:|:...:::..:..:.|..||.
Zfish  1095 NYTQCGPCASLTVCPVCTRSYREEELILQCRQCDRWVHGSCQGLNSDEDVENAADEGFDCTLCRM 1159

  Fly   710 STRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGD----MPESA 770
            .|..|...|..|.                                .|.:.|.:...    :.|:.
Zfish  1160 HTVPTPGAAVPKL--------------------------------VEISEPPMVAQILTKVKENE 1192

  Fly   771 PEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMR-------------QALGNGKDGQLEAAAEEA 822
            .:..:..|||||:||||..::|||.:..|:::.:             ..|....|.|.|...:..
Zfish  1193 FQRTYTQDGVCLTESGLCQLQSLSVQTTRRKRPKPKLKLKIINQNSVAVLQTPPDAQSELFRDGD 1257

  Fly   823 LEKYKDG--MVWDGTENAIPEGFTISINDEGVNILRKKRQRNLQKLGIGGFSVRNRG-------- 877
            |:..::|  |..||..::.||......:.:||:...|||:|...:.|||||.||.|.        
Zfish  1258 LDDSREGDPMDCDGKSDSSPEREHCDDHLKGVDDSNKKRKRKPYRPGIGGFMVRQRSKAGQGKGK 1322

  Fly   878 ---LKKDS----------------EETTAVDQINSLMT--MDKKKKIIRKKQKNKLIEAYPVYLQ 921
               .:|||                |..|.||....:::  ::|.||..||| |.||.||:|.|||
Zfish  1323 RSLSRKDSTSSLTENLTGRDDGWNEPDTPVDGAPPIISEPLEKVKKRYRKK-KTKLEEAFPSYLQ 1386

  Fly   922 EAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPEGKS-----PANQDTLAVNKSPAKTVKKV 981
            ||||||.||:..:    .|.|:.|..|..:...|..:.:|     |.:...|:...:|       
Zfish  1387 EAFFGKELLDKSK----QTKSALETGAVEEASHTDSKSQSSSFLDPLSDPLLSATSTP------- 1440

  Fly   982 KAELKTENKTVFIQQMPMGIQNKNGTTPVSNVFDPL----------------------------- 1017
                               :.:|.||.|  ||.|||                             
Zfish  1441 -------------------VSSKAGTLP--NVEDPLTELVLHSDDDLLGMLSDDLVKPGHESGLD 1484

  Fly  1018 ----QAEISNTVFA-------------------------NRHPLDALASP--------------- 1038
                |.:.|.:.||                         ...|||.:.||               
Zfish  1485 LCPFQVDSSPSPFAGLDIGTLPDDQSVPPHPGPARGSRLQEEPLDVILSPELDKMVSDGAILSKL 1549

  Fly  1039 -NVPEL---DMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQ----EQKFHNQLYLGG-- 1093
             .:|||   |:.:..:.|.|....:.|....|         ||..|.    .....||..:||  
Zfish  1550 YKIPELEGKDVEDLFTAVLSPNASQPPQLPHP---------PNTAPNASAPAMSLQNQGGVGGMF 1605

  Fly  1094 ------------NTLVNPAQQLQ-----------FRQQAPQNANKQNMQTIMSQVVLQTEKRPEE 1135
                        ||...|...:.           .|...|:|..::........|:.........
Zfish  1606 PRMPMMNGMMGPNTHFPPNPMIPVAGVSGTFSSVHRMPFPENVREKKFSQTSGDVIGPWSSPVPV 1670

  Fly  1136 EQKVVEPVTET-LNAGTQKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILK 1199
            ...|..|..|| ..:..|::..|..|:|.||.|||::.|||.|...|||::.||.|..|.|||.|
Zfish  1671 PGSVPPPEVETDTMSNAQRSTLKWEKEETLGEMATVAPVLYTNMNFPNLQDEFPDWATRVKQIAK 1735

  Fly  1200 RWRSLCNEKKAPFLQKAKDNRSALR-----------QRREQN------------------KIPMP 1235
            .||...::::||::|||:|||:|||           :|::|.                  |.|:.
Zfish  1736 LWRKASSQERAPYVQKARDNRAALRINKVQLSNDTMKRQQQQQAVEVFDPNVSMDTDLLFKDPLK 1800

  Fly  1236 PKPQKQE-------EMGRVWKQPPKL---------KEDQPNM-----FVTYNGNAYDMGNYVGGS 1279
            .|..:||       :|.:..||..|:         |.:|..:     .:.|:|:           
Zfish  1801 HKESEQEQEWKFRQQMRQKSKQQAKIEATQKLEQVKNEQQQLQKQQQQLQYSGD----------- 1854

  Fly  1280 AQAASNNPNPHHVMPNVN---DNLVIKATMQRTQVHTTA------------------ASTLKMTT 1323
               |||:|   |.....|   ..|..|.:...||:..||                  :||.|..|
Zfish  1855 ---ASNSP---HTSSGGNSPLQALTPKDSFAMTQMPGTASSGTSADDVFLRPQPPPLSSTSKTPT 1913

  Fly  1324 VDNRLELNTAVYGTEPIGDKKLRNLLQKNSTEPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPM 1388
            .|.:       |...|          ......|.:....|.          |...::|......|
Zfish  1914 QDTQ-------YPQGP----------SSQPQSPQMFSPESS----------GSRPSSPYDPYGKM 1951

  Fly  1389 LSI-----SGKSQPSEGRSLEQDVKLGEPQEATSSAVELENVGF------------------SD- 1429
            :..     ||.|.|..|       .:.:.||....:...|:.|.                  || 
Zfish  1952 VGTPRPPPSGSSTPRRG-------SVSDMQERCRPSSAHESFGSPTTTSTDPYAKPPDTPRPSDP 2009

  Fly  1430 --------LLGGLGEGDDDDLLKSLTSEMGDDFN 1455
                    .||.|.|.....|:.::|.  ||:|:
Zfish  2010 FVKPMCTPRLGSLSEQQGRQLMGNVTP--GDNFS 2041

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135 26/85 (31%)
PHD1_KMT2C_like 205..250 CDD:276984 20/44 (45%)
PHD2_KMT2C_like 252..298 CDD:276985 17/45 (38%)
PHD_SF 337..392 CDD:304600 14/58 (24%)
PHD4_KMT2C_like 530..578 CDD:276987 24/47 (51%)
PHD5_KMT2C_like 580..625 CDD:276988 29/44 (66%)
PHD6_KMT2C_like 657..707 CDD:276989 16/49 (33%)
NHP6B 1101..>1237 CDD:227935 49/176 (28%)
HMG 1173..1231 CDD:197700 30/86 (35%)
kmt2caXP_005162602.1 PHD_SF 263..346 CDD:304600 26/85 (31%)
PHD1_KMT2C_like 360..404 CDD:276984 20/43 (47%)
PHD2_KMT2C 406..451 CDD:277069 17/45 (38%)
PHD_SF 484..535 CDD:304600 14/59 (24%)
PHD4_KMT2C 973..1029 CDD:277071 27/55 (49%)
PHD5_KMT2C_like 1030..1076 CDD:276988 29/45 (64%)
PHD_SF 1108..1157 CDD:304600 16/48 (33%)
HMG 1707..1760 CDD:197700 26/52 (50%)
CITED 2586..>2683 CDD:282356
ePHD2_KMT2C 4440..4544 CDD:277167
FYRN 4599..4649 CDD:283589
FYRC 4656..4736 CDD:283590
SET 4819..4940 CDD:214614
SET <4820..4958 CDD:225491
PostSET 4942..4958 CDD:214703
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 131 1.000 Domainoid score I5115
eggNOG 1 0.900 - - E2759_KOG4443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D39671at33208
OrthoFinder 1 1.000 - - FOG0002860
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_102575
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X2220
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.840

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