DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and KMT2E

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:NP_061152.3 Gene:KMT2E / 55904 HGNCID:18541 Length:1858 Species:Homo sapiens


Alignment Length:1143 Identity:226/1143 - (19%)
Similarity:362/1143 - (31%) Gaps:393/1143 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   577 DCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKC---------- 631
            |.|.|. ||..:|:..::.||:|.:..||.|:....:.:|.       ..||::|          
Human   117 DVTRCI-CGFTHDDGYMICCDKCSVWQHIDCMGIDRQHIPD-------TYLCERCQPRNLDKERA 173

  Fly   632 ---GRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLT 693
               .|...|....||::..|     |....||                 ||:..|.....:..||
Human   174 VLLQRRKRENMSDGDTSATE-----SGDEVPV-----------------ELYTAFQHTPTSITLT 216

  Fly   694 IDHY--------------DNNVYKCFKC-RCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITA 743
            ....              :.::.||.|. |..:|.::.:               :||.|.:. .:
Human   217 ASRVSKVNDKRRKKSGEKEQHISKCKKAFREGSRKSSRV---------------KGSAPEID-PS 265

  Fly   744 SSGPSF--DSKSGA------ERNHPTLS-GDMPESAPEALHWIDG--------VCLSESGLGMIK 791
            |.|.:|  ::|..|      |.|:...| |...|:...||...:|        ..|:.:.|....
Human   266 SDGSNFGWETKIKAWMDRYEEANNNQYSEGVQREAQRIALRLGNGNDKKEMNKSDLNTNNLLFKP 330

  Fly   792 SLSTEIKRKRKMRQALGNGKD-----------------GQLEA---------------AAEEALE 824
            .:.:.|::.:|:   |.:.||                 .|.||               :....||
Human   331 PVESHIQKNKKI---LKSAKDLPPDALIIEYRGKFMLREQFEANGYFFKRPYPFVLFYSKFHGLE 392

  Fly   825 KYKDGM----------------------VWDGT-------ENAIPEGFTISI------------- 847
            ...|..                      :.|||       .::||:|..|:|             
Human   393 MCVDARTFGNEARFIRRSCTPNAEVRHEIQDGTIHLYIYSIHSIPKGTEITIAFDFDYGNCKYKV 457

  Fly   848 -------NDEGVNILRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTAVDQINSLMTMD-----KK 900
                   |.| ..:| |:...:::.:. .|:..|.:..|||.:.:...|..|..:|:|     .|
Human   458 DCACLKENPE-CPVL-KRSSESMENIN-SGYETRRKKGKKDKDISKEKDTQNQNITLDCEGTTNK 519

  Fly   901 KKIIRKKQKNKLIEAYPVYL-----QEAFFGKPLLE----GGELVMADTDSSDEIDASMKVYFTR 956
            .|....||:    :..|:.|     ||..|...:.|    ..|:.|    .|:|..|..|...||
Human   520 MKSPETKQR----KLSPLRLSVSNNQEPDFIDDIEEKTPISNEVEM----ESEEQIAERKRKMTR 576

  Fly   957 PEGKSPANQDTLA-------VNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVF 1014
            .|.|..|.....|       ..:...:.:...|.|:|||.|...|......||.:   ....|..
Human   577 EERKMEAILQAFARLEKREKRREQALERISTAKTEVKTECKDTQIVSDAEVIQEQ---AKEENAS 638

  Fly  1015 DPLQAEISNT----VFA----------NRHPLDALAS---PNVPEL-------DMANSVSTVPS- 1054
            .|..|:::.|    .|:          .||...::.|   |:.|::       |:.|:|.|:.. 
Human   639 KPTPAKVNRTKQRKSFSRSRTHIGQQRRRHRTVSMCSDIQPSSPDIEVTSQQNDIENTVLTIEPE 703

  Fly  1055 -----AEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVN------------PAQQ 1102
                 ||:|.:  .|.||:    ...|.:.|:.:|.          |||            |:..
Human   704 TETALAEIITE--TEVPAL----NKCPTKYPKTKKH----------LVNEWLSEKNEKTGKPSDG 752

  Fly  1103 LQFR---------------QQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQ 1152
            |..|               ...|......::.:.....:..|.....|:::..|| ||.::...:
Human   753 LSERPLRITTDPEVLATQLNSLPGLTYSPHVYSTPKHYIRFTSPFLSEKRRRKEP-TENISGSCK 816

  Fly  1153 KTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRS--LCNEKKAPFLQ- 1214
            |...|...:|:      .||:|:.             :|..|::   |.||  :..|.|:|.|. 
Human   817 KRWLKQALEEE------NSAILHR-------------FNSPCQE---RSRSPAVNGENKSPLLLN 859

  Fly  1215 ---KAKDNRSALRQRR---------EQNKIPMP-----PKPQKQEEMGRVWKQPPKLKEDQPNMF 1262
               ...|..:.|::||         .:...|.|     |.......|...:..||::|.|.....
Human   860 DSCSLPDLTTPLKKRRFYQLLDSVYSETSTPTPSPYATPTHTDITPMDPSFATPPRIKSDDETCR 924

  Fly  1263 VTYN--------------GNAYDMGNYVGG-----------SAQAASNNPNPHHVMPNVNDNLVI 1302
            ..|.              ||.....|....           |.:....:.....:.|..|.||  
Human   925 NGYKPIYSPVTPVTPGTPGNTMHFENISSPESSPEIKRRTYSQEGYDRSSTMLTLGPFRNSNL-- 987

  Fly  1303 KATMQRTQVHTTAASTLKMTTVDNRLELNTAVYG-TEPIGDKKL------RNLLQKNSTEPMLMG 1360
                  |::......|:..|:..:|.|:|....| .||:.|.:|      ...|.|....|....
Human   988 ------TELGLQEIKTIGYTSPRSRTEVNRQCPGEKEPVSDLQLGLDAVEPTALHKTLETPAHDR 1046

  Fly  1361 A--NSDL---FLGNDVM---------RLGMMQNTPITQN------NPMLSISGKSQPSEGRSLEQ 1405
            |  ||.|   ..|...|         |.|:  |..:..|      :..|.:.|..:.||.:.|.|
Human  1047 AEPNSQLDSTHSGRGTMYSSWVKSPDRTGV--NFSVNSNLRDLTPSHQLEVGGGFRISESKCLMQ 1109

  Fly  1406 DVKLGEPQEATSSAVELENVGFSDLLGGLGEGDDDDLL 1443
            |...|...|.|......:.     |:.|.|...:|:|:
Human  1110 DDTRGMFMETTVFCTSEDG-----LVSGFGRTVNDNLI 1142

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135
PHD1_KMT2C_like 205..250 CDD:276984
PHD2_KMT2C_like 252..298 CDD:276985
PHD_SF 337..392 CDD:304600