DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and ASH1L

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:NP_001353106.1 Gene:ASH1L / 55870 HGNCID:19088 Length:2969 Species:Homo sapiens


Alignment Length:1051 Identity:181/1051 - (17%)
Similarity:339/1051 - (32%) Gaps:332/1051 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   630 KCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMI--IQCEHCELWAHFHCDSVN--- 689
            |.|:...||:|       .|||....|..      |...:.:  |:|:..|: ...|....|   
Human   124 KSGKMTDEKNE-------HCPSKRDPSKL------YKKADDVAAIECQSEEV-IRLHSQGENNPL 174

  Fly   690 -AQLTIDHYDNNVYKCFKCRCSTRSTNSLADAKFGNED----SLAITPQG---SKPFVHITASSG 746
             .:|:..|.:...|           .|:......|:.|    ..|:...|   ::....:.|:..
Human   175 SKKLSPVHSEMADY-----------INATPSTLLGSRDPDLKDRALLNGGTSVTEKLAQLIATCP 228

  Fly   747 PSFDSKS-----GAERNHPTLSGDMPESAPEALHWIDGVCLSESGLGMIKS-LSTEIKRKRKMRQ 805
            ||..||:     |.......:|.|:               :.::|:|.:.. :..::.:|..:..
Human   229 PSKSSKTKPKKLGTGTTAGLVSKDL---------------IRKAGVGSVAGIIHKDLIKKPTIST 278

  Fly   806 ALG-----NGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFT-ISINDE---------GVNIL 855
            |:|     .||.....||.         |:|...:...:..|.| :.||..         .|.:|
Human   279 AVGLVTKDPGKKPVFNAAV---------GLVNKDSVKKLGTGTTAVFINKNLGKKPGTITTVGLL 334

  Fly   856 RKKRQRNL--------------QKLGIG---GFSVRNRGLK---------KDSEETTAVDQINSL 894
            .|...:.|              :|||:|   |...::.|.|         ||..:.........|
Human   335 SKDSGKKLGIGIVPGLVHKESGKKLGLGTVVGLVNKDLGKKLGSTVGLVAKDCAKKIVASSAMGL 399

  Fly   895 MTMDKKKKI-------------------------------------------------------- 903
            :..|..||:                                                        
Human   400 VNKDIGKKLMSCPLAGLISKDAINLKAEALLPTQEPLKASCSTNINNQESQELSESLKDSATSKT 464

  Fly   904 ----IRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDE--------IDASMKVYFTR 956
                :.::.|..::|.:.|..:.....|.:...|..:..|:.||.|        .:....||.|.
Human   465 FEKNVVRQNKESILEKFSVRKEIINLEKEMFNEGTCIQQDSFSSSEKGSYETSKHEKQPPVYCTS 529

  Fly   957 PEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQM---PMGIQNKNGTTP--VSNVFDP 1016
            |:.|.....| ::..|||...|.  ::.|.:.:.||.:..:   |....::....|  :|:..:.
Human   530 PDFKMGGASD-VSTAKSPFSAVG--ESNLPSPSPTVSVNPLTRSPPETSSQLAPNPLLLSSTTEL 591

  Fly  1017 LQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQ 1081
            :: |||.:|..|:...:: ...||....:.:|:|.  ..:.|:|.:.:|....:|...:.:.|.:
Human   592 IE-EISESVGKNQFTSES-THLNVGHRSVGHSISI--ECKGIDKEVNDSKTTHIDIPRISSSLGK 652

  Fly  1082 EQK--------------------FHNQ--LYLGG--------NTLVNPAQQLQFRQQAPQNANKQ 1116
            :..                    |.|:  |.||.        ....:.:..||.:....:...|.
Human   653 KPSLTSESSIHTITPSVVNFTSLFSNKPFLKLGAVSASDKHCQVAESLSTSLQSKPLKKRKGRKP 717

  Fly  1117 NMQTIMSQVVLQTEKRPE-EEQKVVEPVT-ETLNAGTQKTAEKMRK-------DED--------L 1164
            ....::::...::.|..| |..::.:.|: .:|:....:.|:.|:.       |.|        |
Human   718 RWTKVVARSTCRSPKGLELERSELFKNVSCSSLSNSNSEPAKFMKNIGPPSFVDHDFLKRRLPKL 782

  Fly  1165 GLMATISAVLYANTEHPN--------LKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRS 1221
            ......|..|.|::|.|:        |.....:.:|....|.|..|.....|:.|.|: ....|:
Human   783 SKSTAPSLALLADSEKPSHKSFATHKLSSSMCVSSDLLSDIYKPKRGRPKSKEMPQLE-GPPKRT 846

  Fly  1222 ---------ALRQRREQN--------KIP-------MPPKPQKQEEMGRVWKQPPKLK------- 1255
                     :|:.:.||.        :||       :.|.|:|:....|..:.|.|:|       
Human   847 LKIPASKVFSLQSKEEQEPPILQPEIEIPSFKQGLSVSPFPKKRGRPKRQMRSPVKMKPPVLSVA 911

  Fly  1256 ----EDQPNMFVTYNGNAYDMGNYVGGSAQAA-------SNNPN----------PHHVMPNVNDN 1299
                .:.|:...:.:.|.....::.....|..       |:.|:          |...:...|:.
Human   912 PFVATESPSKLESESDNHRSSSDFFESEDQLQDPDDLDDSHRPSVCSMSDLEMEPDKKITKRNNG 976

  Fly  1300 LVIKATMQRTQVHTTAASTLKMTTVDNRLELNTAVYGTEPIGDK-----KLRNLLQKNST----- 1354
            .::|..:::..         ||.|:..:..||..:..:....:|     ||.|.:...:.     
Human   977 QLMKTIIRKIN---------KMKTLKRKKLLNQILSSSVESSNKGKVQSKLHNTVSSLAATFGSK 1032

  Fly  1355 --EPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPMLSISGKS--------QPSEGRSLEQDVKL 1409
              :.:.:.....:::|.   |.|   ..|.|..|.:||.|..|        |.:.|.:|.|.:..
Human  1033 LGQQINVSKKGTIYIGK---RRG---RKPKTVLNGILSGSPTSLAVLEQTAQQAAGSALGQILPP 1091

  Fly  1410 GEPQEATSSAV 1420
            ..|..|:||.:
Human  1092 LLPSSASSSEI 1102

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135
PHD1_KMT2C_like 205..250 CDD:276984
PHD2_KMT2C_like 252..298 CDD:276985
PHD_SF 337..392 CDD:304600
PHD4_KMT2C_like 530..578 CDD:276987
PHD5_KMT2C_like 580..625 CDD:276988
PHD6_KMT2C_like 657..707 CDD:276989 9/55 (16%)
NHP6B 1101..>1237 CDD:227935 32/184 (17%)
HMG 1173..1231 CDD:197700 16/82 (20%)
ASH1LNP_001353106.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..70
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 118..143 8/25 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 501..525 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..583 9/48 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 824..845 5/21 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..966 12/87 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1128 1/3 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1151..1231
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1243..1281
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1489..1508
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1580..1711
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1741..1761
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1911..1991
Catalytic domain 2069..2288
AWS 2092..2143 CDD:197795
SET 2146..2266 CDD:214614
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2288..2346
Bromo_ASH1 2443..2548 CDD:99955
PHD_ASH1L 2586..2628 CDD:277023
BAH_polybromo 2665..2799 CDD:240068
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2825..2856
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2876..2919
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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