DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and phf3

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_005157087.1	Gene:	phf3 / 553518	ZFINID:	ZDB-GENE-090313-207	Length:	1691	Species:	Danio rerio

Alignment Length:	1267	Identity:	234/1267 - (18%)
Similarity:	391/1267 - (30%)	Gaps:	360/1267 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 EEADLTAYHKKKEQNPDYDYVCPNCKSNSSGPGSS---------QQTIDSIVLSAMDSSSEQLSL 423
            |...|:..:.:|   |..|.| |...:||..|.:|         :.:.:|:.||..:|.....:|
Zfish   421 ESGPLSPTNSRK---PSSDSV-PLSPTNSRKPSNSVPLSSTNSRKPSSNSVPLSPSNSRKPSSNL 481

  Fly   424 --------KEIELD--PLEGKPTMDPSSDELHKLPTGKKKVCLTSVRGRSGKFVLHRMGVMS--- 475
                    :::..|  ||....:..||||.:...||..::     ....||.      ||.|
Zfish   482 VPLSPTNSRKLSSDSGPLSPTNSRKPSSDSVPLSPTNSRR-----PSSESGP------GVKSVQS 535

  Fly   476 --QINKKRSTRGKGRQLALPTISSDRCLSRSMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLG 538
              ...|.::....|.:...|..:|    ....|.|....||:.....|.|...::.|.:....|.
Zfish   536 PHPPKKPQNPPTSGNKTNPPVANS----QGDEEQDKVKAKKIEKTQQRHKSRNSRSISIEEPQLF 596

  Fly   539 IESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCEGCGKKNDEARLLLCDECDISY 603
            |..::.::                                       ||..|...|
Zfish   597 IPDNAPVV---------------------------------------KKEAEGDAL--------- 613

  Fly   604 HIYCVNPPLETV--PTGNWKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYS 666
                  ...|||  ||.|     |.||:|                            |      .
Zfish   614 ------AESETVWDPTKN-----CVLCKK----------------------------P------H 633

  Fly   667 NGEMIIQCEHCELWAHFHCDSVN-AQLTIDHYDNNVYKCFKCRCSTR----STNSLAD----AKF 722
            |...::.|..|:.|.|..|..:: |::.....::..|.|.|| |:..    ..:.|:|    ||.
Zfish   634 NNRFMVGCGRCDDWFHGDCVGLDLAKVQQMEKEDQEYVCLKC-CAQEDEKTQASELSDDKSAAKQ 697

  Fly   723 GNEDSLAITPQGSKPFVHITASSGPSFDS-KSGAERNHPT-------------LSGDMPESAPEA 773
            ......::|..|.:||........||.|| :.|....|.|             .:|.:..|..::
Zfish   698 KQRPQQSLTAGGIRPFRKDAGERRPSEDSAQKGPNVKHETKKVKISPVSSKKPSTGHIRRSVRDS 762

  Fly   774 LHWIDGVCLSESGLGMIKSLSTEI-KRKRKMRQALGNGKDGQLEAAAEEALEKYKDGMVWDGTEN 837
            |..|......||.|.:......|: :|..|...||..|.|           .|||:..
Zfish   763 LEEILLKRSKESDLKISSDRPAEVARRTEKELFALFQGVD-----------SKYKNKY------- 809

  Fly   838 AIPEGFTISINDEGVNILRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTAVDQINSLMTMDKKKK 902
               ...|.::.|...|:|.|:..:.         .|....|.:.:.|..|..::.:....:.:..
Zfish   810 ---RSLTFNLKDAKNNVLFKRVLKG---------EVSPADLVRMTAEELASKELAAWRKRENRHT 862

  Fly   903 I--IRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPEGKSP--- 962
            |  |.|:|:.  :|..|: .:....|:..:|..|...|......|.:..:||... ||.|.|
Zfish   863 IEMIEKEQRE--VERRPI-TKITHKGEIEIENQEPAKAPEAIEVEPEPVLKVVEV-PEEKPPEIK 923

  Fly   963 -----ANQDTLAVNKS-------------------PAKT-VKKVKAELKTENKTVFIQQMPMGIQ 1002
                 .:.||..::||                   .|.| |.||...:.....:...:..|
Zfish   924 VESPKKSIDTTNLHKSHLFDLNCKICTGRMAPPTEEASTKVVKVATTVVRRQSSATEESQP---- 984

  Fly  1003 NKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMRESPA 1067
              :.|||.|.:.|.|..........|..|..:.|.....:.|.|..:|   |.|.:.....:.||
Zfish   985 --STTTPTSALMDDLTLRAMEEGLLNFLPESSRADSLCSKEDTATFLS---SLESLWGGYVDMPA 1044

  Fly  1068 V---LVDSFMVPNQLPQ-EQKFHNQLYLGGNTLVNPAQQLQFRQQAPQNANKQ------------ 1116
            |   |..|::|...|.. .|...:.:.:||.  ::|.....:.::...:..|:
Zfish  1045 VARFLTKSYLVSGTLDHLTQDLPDNIQVGGR--ISPQIVWDYVEKIRASGTKEICVIRFSPDTEE 1107

  Fly  1117 -----------------------NMQTIMSQVVL---QTEKRPEEEQKVVEPVTET----LNAGT 1151
                                   |.:.:....::   .|||.|.:......|..||    |..|
Zfish  1108 DEISYTLLYAYFSSRRRYGVVANNRKQVKDMYLIPLGSTEKIPHQIVPFDGPGLETNRPNLLLG- 1171

  Fly  1152 QKTAEKMRKDEDLG--LMATISAV------------------LYANTEHPNLKELFPIWNDRCKQ 1196
              ...:.|...|.|  |.:.:|..                  :..:||...:.:|   .|.|.|.
Zfish  1172 --LIIRQRPKRDFGVILPSDVSEAPSFLAESKPQVDYPQKTPVALDTEQSFISDL---GNARKKD 1231

  Fly  1197 ILKRWRSLCNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNM 1261
            .....:|:..|   |.|....|...:||......|:|........:.|.   ....|.:...|::
Zfish  1232 TTDLIKSVVEE---PILDTETDENVSLRFLPGVLKLPEKAASCSNDNMK---SDSTKTEAKTPSV 1290

  Fly  1262 FVTYNGNAYDMGNYVGGSAQAASNNPNPHHVMPNVNDNLVIKATMQRTQVHTTAASTLKMTTV-- 1324
                     |.||....|.:..::.|.....:....:...:|.......|....:|..|.|.|
Zfish  1291 ---------DSGNNATVSPKPIASAPRLDRFVIKKKEPKAVKTEQAPVSVSLEISSEKKETAVVL 1346

  Fly  1325 ---DNRLELNT-----AVYGTEPIGDKKLRNLLQKNSTEPMLMGANSDLFLGNDVMRLG------ 1375
               |...:::|     ::..|:|..:.:..:.....|.|.....::.   ...|.:..|
Zfish  1347 SLSDKPADVSTESFLSSLTNTKPKEESESCSTASPTSQETSQTTSSG---TSKDSVDEGSSSAPK 1408

  Fly  1376 ---MMQNTPITQNNP---MLSISGKSQPSEGR----SLEQDVKLGEPQEATSSAVELENVGFSDL 1430
               :...|..|:.:|   :...|...:|:|.:    |.|:..:...||.:|.....:|::.....
Zfish  1409 NETISSPTATTKVSPAGILKRASSAPEPTESKLPESSSEKPEQKVTPQPSTQECKAIEDIQAITT 1473

  Fly  1431 LGGLGEGDDDDLLKSLTSEMGDDFNILEYADP 1462
            :..:|:.:      .|.......||...|..|
Zfish  1474 ISSIGKNE------GLKQSRSSSFNPKVYNPP 1499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600	7/23 (30%)
		PHD4_KMT2C_like	530..578	CDD:276987	3/47 (6%)
		PHD5_KMT2C_like	580..625	CDD:276988	10/46 (22%)
		PHD6_KMT2C_like	657..707	CDD:276989	10/50 (20%)
		NHP6B	1101..>1237	CDD:227935	31/197 (16%)
		HMG	1173..1231	CDD:197700	13/75 (17%)
phf3	XP_005157087.1	DUF4045	<341..732	CDD:330572	83/423 (20%)
		PHD_PHF3	625..675	CDD:277108	15/88 (17%)
		TFIIS_M	755..863	CDD:311443	25/137 (18%)
		SPOC	1027..1176	CDD:311609	25/156 (16%)
		Endomucin	1271..>1449	CDD:330316	30/192 (16%)
		RRM	1605..>1690	CDD:330708
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030