DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and SETD5

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_011532222.1	Gene:	SETD5 / 55209	HGNCID:	25566	Length:	1500	Species:	Homo sapiens

Alignment Length:	1252	Identity:	236/1252 - (18%)
Similarity:	386/1252 - (30%)	Gaps:	414/1252 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 CPNCKSNSSGP-----GSSQQTIDSIVLSAMDSSSEQLSLKEIELDPLEGKPTMDPSSDELHKLP 448
            |..|:..|.|.     ...|..|.....||.:|..|:||...:.....:..||    |..|....
Human   132 CDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPT----SITLTVRR 192

  Fly   449 TGKKKVCLTSVRGRSG----KFVLHRMGVMSQINKKRS-----------TRGKGRQLALPTISSD 498
            |..||...:..:||:.    |....|.|....:..|.|           |.|...::.|.|...:
Human   193 TKPKKRKKSPEKGRAAPKTKKIKAFREGSRKSLRMKNSPSEAQNLDENTTEGWENRIRLWTDQYE 257

  Fly   499 RCLSRSMETDLTSDKKLLLCSARDKFIQAQDIC-------VMCGSLGIESDSVMITCAQCGQCYH 556
            ...:.....|:.:..:..|.|::: |:....|.       :.|.:..|.|...:    |.|:
Human   258 EAFTNQYSADVQNALEQHLHSSKE-FVGKPTILDTINKTELACNNTVIGSQMQL----QLGR--- 314

  Fly   557 PYCAGVKPSRGILQKGW-RCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNW 620
              ...|:..|.||:... ..||..:.|..||      ::|..:.:::.|.:....|.....:
Human   315 --VTRVQKHRKILRAARDLALDTLIIEYRGK------VMLRQQFEVNGHFFKKPYPFVLFYS--- 368

  Fly   621 KCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHC 685
            |.:...:|       .:...||:.......|||     |..:|.:...:.:|   |..::| ...
Human   369 KFNGVEMC-------VDARTFGNDARFIRRSCT-----PNAEVRHMIADGMI---HLCIYA-VSA 417

  Fly   686 DSVNAQLTI--DH-YDNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGP 747
            .:.:|::||  |: |.|..|| ..|.|...:.|.....:..|...|.:.|.
Human   418 ITKDAEVTIAFDYEYSNCNYK-VDCACHKGNRNCPIQKRNPNATELPLLPP-------------- 467

  Fly   748 SFDSKSGAERNHPTLSGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQALGNGKD 812
                               |.|.|                    ::..|.:|::..|:.|  ..:
Human   468 -------------------PPSLP--------------------TIGAETRRRKARRKEL--EME 491

  Fly   813 GQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNILRKKRQRNLQKLGIGGFSVRNRG 877
            .|.||:.|..          |.....:||..|:|.:.|.|:                     |..
Human   492 QQNEASEENN----------DQQSQEVPEKVTVSSDHEEVD---------------------NPE 525

  Fly   878 LKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDS 942
            .|.:.|:...:|...:|...       |:.::::.:||    :..||
Human   526 EKPEEEKEEVIDDQENLAHS-------RRTREDRKVEA----IMHAF------------------ 561

  Fly   943 SDEIDASMKVYFTRPEGKSPANQD---TLAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNK 1004
             :.::...|   .|.:....:|.|   |...:::|      |..|.|||
Human   562 -ENLEKRKK---RRDQPLEQSNSDVEITTTTSETP------VGEETKTE---------------- 600

  Fly  1005 NGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIE---------- 1059
               .|        ::|:||:|          ::..:|....:..|:|..|::..:
Human   601 ---AP--------ESEVSNSV----------SNVTIPSTPQSVGVNTRRSSQAGDIAAEKLVPKP 644

  Fly  1060 ---KPMRESPAVLVDSFMVPN-QLPQEQKFHN-------QLYL---GGNTLVNPAQQLQF---RQ 1107
               ||.|..|...:..:...: |..:.||..|       |..|   |.|:||.|.:....   .:
Human   645 PPAKPSRPRPKSRISRYRTSSAQRLKRQKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGE 709

  Fly  1108 QAPQNANKQNMQTIM-SQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLMATIS 1171
            ..|...:...:.:|. |.|.....|.|:.::.:   |||.||    ..|||.....:..|..|..
Human   710 NRPLTGSDPTVVSITGSHVNRAASKYPKTKKYL---VTEWLN----DKAEKQECPVECPLRITTD 767

  Fly  1172 AVLYANTEH--PNL-----------------------KELFPIWND----RCKQILKRW------ 1201
            ..:.|.|.:  |.|                       :...|:..|    .||   |||
Human   768 PTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSSCK---KRWIKQALE 829

  Fly  1202 ------RSLCNEKKAPFLQKAKDNRSA------------------LRQRREQN--KIPMPPKPQK 1240
                  .|:..|.:...|.::.:|.|:                  .|...|||  |:..|..|
Human   830 EGMTQTSSVPQETRTQHLYQSNENSSSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLRPLSP-- 892

  Fly  1241 QEEMGRVWKQPPKLKEDQPNMFV---TYNG-----NAYDMGNYVGGSAQAAS--NNP-------- 1287
                  |...||......|.:..   ::.|     |.|.:......|...||  |.|
Human   893 ------VTPPPPNSGSKSPQLATPGSSHPGEEECRNGYSLMFSPVTSLTTASRCNTPLQFENISS 951

  Fly  1288 ---NPHHVMPNVNDNLVIKATMQRTQVHTTAASTLKMTTVDNRLELNTAVYGTEP---------- 1339
               :|.|...:::..|..:..:...:|....::|  .:..|....||:......|
Human   952 PESSPAHRPESLSPELCHRKDLDLAKVGYLDSNT--NSCADRPSLLNSGHSDLAPHPSLGPTSET 1014

  Fly  1340 -----IGD---KKLRNLLQKNSTEPMLMGANSDLFLGNDVMRL-GMMQNTPIT-QNNPMLSISGK 1394
                 .||   ..:||..|...||..||.|.|.|   |.:.|. |:.:.:|:. ...|:....|.
Human  1015 GFPSRSGDGHQTLVRNSDQAFRTEFNLMYAYSPL---NAMPRADGLYRGSPLVGDRKPLHLDGGY 1076

  Fly  1395 SQPSEGRS------LEQDVKLGE-------------------PQEATSSAVELENVGFSDLLGGL 1434
            ..|:||.|      |.:|:..|.                   ||....|.:|.............
Human  1077 CSPAEGFSSRYEHGLMKDLSRGSLSPGGERACEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENSA 1141

  Fly  1435 GEGDDDDLLKSLTSEMG 1451
            |.|.|....||.::..|
Human  1142 GGGGDSAQSKSKSAGAG 1158

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600	1/2 (50%)
		PHD4_KMT2C_like	530..578	CDD:276987	11/55 (20%)
		PHD5_KMT2C_like	580..625	CDD:276988	7/44 (16%)
		PHD6_KMT2C_like	657..707	CDD:276989	13/52 (25%)
		NHP6B	1101..>1237	CDD:227935	38/200 (19%)
		HMG	1173..1231	CDD:197700	20/118 (17%)
SETD5	XP_011532222.1	SET_SETD5	305..454	CDD:380958	38/183 (21%)
		COG5644	<473..>693	CDD:227931	56/328 (17%)
		PLN02217	<1360..1467	CDD:215130
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030