DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpt and PBRM1

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_016862214.1	Gene:	PBRM1 / 55193	HGNCID:	30064	Length:	1734	Species:	Homo sapiens

Alignment Length:	815	Identity:	145/815 - (17%)
Similarity:	243/815 - (29%)	Gaps:	330/815 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 LSGDMPESAP-------EALHWI----------DGVCLSESGLGMIKSLSTEIKRKRKM-----R 804
            |.||.....|       |.:|.:          :|.|.|:| |..|.::......|..:     |
Human   808 LEGDEDSHVPNVTLLIQELIHNLFVSVMSHQDDEGRCYSDS-LAEIPAVDPNFPNKPPLTFDIIR 871

  Fly   805 QALGNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEG------FTISINDE-----------GV 852
            :.:.|.:..:|:...|...|..:.....:.|::.|.|.      |.|.|.||           .:
Human   872 KNVENNRYRRLDLFQEHMFEVLERARRMNRTDSEIYEDAVELQQFFIKIRDELCKNGEILLSPAL 936

  Fly   853 NILRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNK------ 911
            :...|....:::|       .|...|.|:.||             ||.|:...|::..|
Human   937 SYTTKHLHNDVEK-------ERKEKLPKEIEE-------------DKLKREEEKREAEKSEDSSG 981

  Fly   912 ---LIEAYPVYLQEAFFGKPLLEGGELVMADTDSSD------------EIDASMK----VYFTRP 957
               |...:..|.|:..|...:...|:.|..:...::            |..|..|    .:|.||
Human   982 AAGLSGLHRTYSQDCSFKNSMYHVGDYVYVEPAEANLQPHIVCIERLWEDSAGEKWLYGCWFYRP 1046

  Fly   958 EGKSPANQDT--LAVNKSPAKTVKK--------------------VKAELK--TEN---KTVFIQ 995
                   .:|  ||..|...|.|.|                    ||...|  .||   :.||:.
Human  1047 -------NETFHLATRKFLEKEVFKSDYYNKVPVSKILGKCVVMFVKEYFKLCPENFRDEDVFVC 1104

  Fly   996 QMPMGIQNKN------GTTPVSNV-FDPLQAEIS----NTVFANR----------HPLDALASPN 1039
            :.....:.|:      .|.|:|:| |.|....:.    .:||||.          :..|:.|..|
Human  1105 ESRYSAKTKSFKKIKLWTMPISSVRFVPRDVPLPVVRVASVFANADKGDDEKNTDNSEDSRAEDN 1169

  Fly  1040 ---------VPELDMANSVSTVPSAEVIEKP------MRESPAVLVDS----------------- 1072
                     || ::|:|.   .|.....|:.      ::....|.:.|
Human  1170 FNLEKEKEDVP-VEMSNG---EPGCHYFEQLHYNDMWLKVGDCVFIKSHGLVRPRVGRIEKVWVR 1230

  Fly  1073 ----------FMVPNQL---PQEQKFHNQLYLGG-------NTLVNPAQQLQFRQ-------QAP 1110
                      |:.|.:.   |.:..:..:::|..       ..::.....|.|:.       :.|
Human  1231 DGAAYFYGPIFIHPEETEHEPTKMFYKKEVFLSNLEETCPMTCILGKCAVLSFKDFLSCRPTEIP 1295

  Fly  1111 QN-----------ANKQ-------------------NMQTIMSQVVLQTEKRP------------ 1133
            :|           ::||                   .:......:|.|.|..|
Human  1296 ENDILLCESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIVPQKEPSPLLEKKIQLLEAK 1360

  Fly  1134 ---------------EEEQKVVEP----------------VTETLNAGTQKTAEKMRKDEDLGLM 1167
                           ||:.:|:||                :..|....|.|:|:...|.|.....
Human  1361 FAELEGGDDDIEEMGEEDSEVIEPPSLPQLQTPLASELDLMPYTPPQSTPKSAKGSAKKEGSKRK 1425

  Fly  1168 ATISAVLYANTE--------HPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKA-----KDN 1219
            ..:|..:..::|        ||:..     :.:..:.:...||:|...|||.:.::|     :..
Human  1426 INMSGYILFSSEMRAVIKAQHPDYS-----FGELSRLVGTEWRNLETAKKAEYEERAAKVAEQQE 1485

  Fly  1220 RSALRQRREQNKIPM-------------PPKP------QKQEEMGRVWKQPPKLKEDQPNMFVTY 1265
            |....|:::.:..|.             ||.|      |.....|.:...||.|    |.:....
Human  1486 RERAAQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGMMGGYPPGL----PPLQGPV 1546

  Fly  1266 NGNAYDMGN----YVGGSAQAASNNPNPHHVMPNV 1296
            :| ...||:    :.||        |.|||:.|.|
Human  1547 DG-LVSMGSMQPLHPGG--------PPPHHLPPGV 1572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	36/241 (15%)
		HMG	1173..1231	CDD:197700	12/70 (17%)
PBRM1	XP_016862214.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900