DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpt and NSD3

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_075447.1	Gene:	NSD3 / 54904	HGNCID:	12767	Length:	1437	Species:	Homo sapiens

Alignment Length:	764	Identity:	156/764 - (20%)
Similarity:	226/764 - (29%)	Gaps:	315/764 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 SDNNVECLSCSSLGDLSKLIMC-STCGDHFHSTCIGLANLPDTRSGWNCARCT----KCQICRQQ 259
            |..:..|..|.|.||  .||.| ..|..|||..|:|||:|||::  :.|..|.    .|..|: .
Human   698 SKKDTVCQICESSGD--SLIPCEGECCKHFHLECLGLASLPDSK--FICMECKTGQHPCFSCK-V 757

  Fly   260 DSNDTKYVKCEQCQKTYHASCLRPVISAI--------PKY------------------GWKCNRC 298
            ...|.|......|.|.||.:|:|...:||        |::                  ..:|.||
Human   758 SGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRC 822

  Fly   299 RVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQR-------NKGFSCPICQK-------------- 342
            .|....|......|  |...|.|.:..|.:.:|       |.|| |.:|.:
Human   823 PVAYHSGDACIAAG--SMLVSSYILICSNHSKRSSNSSAVNVGF-CFVCARGLIVQDHSDPMFSS 884

  Fly   343 -AYR----------------------AASHKEMVK------CSWCNKFVHSTC------------ 366
             ||:                      :||.|:..|      |..|....|..|
Human   885 YAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNC 949

  Fly   367 -DEEADLTAYHKK--------------KEQNP-----------------------DYDY------ 387
             |.:|....::|:              :..||                       .:||
Human   950 NDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQG 1014

  Fly   388 -VCP---NCKSNSSGPGSSQQTIDSIV---------LSAMDSSSEQLSL----------KEIELD 429
             |.|   ..||.:.|..|..:|....:         |.|...|.|.|.:          |.|:.:
Human  1015 RVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKAN 1079

  Fly   430 PLEGKPTMD-------------PSSDELHKLPTGKKKVCL------------------------- 456
            .:.||..:.             |:.:.    |.|.:..||
Human  1080 KVIGKVQIQVADLSEIPRCNCKPADEN----PCGLESECLNRMLQYECHPQVCPAGDRCQNQCFT 1140

  Fly   457 -----------TSVRG---------RSGKFVLHRMGVM-----SQINKKRSTRGKGRQLALPTIS 496
                       |..||         :.|:||...:|.:     .::..||:.........:.|::
Human  1141 KRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVT 1205

  Fly   497 SDRCL--------SRSM--------ET-----------------------DLTSDKKL-LLCSAR 521
            .||.:        ||.|        ||                       :||.:..| .|.:.|
Human  1206 KDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGR 1270

  Fly   522 DKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCEGCGK 586
            .:.....|.|  .|.||:...|   .||...: .....|.:|..|..::...:.:....|..||
Human  1271 TECHCGADNC--SGFLGVRPKS---ACASTNE-EKAKNAKLKQKRRKIKTEPKQMHEDYCFQCG- 1328

  Fly   587 KNDEARLLLCD--ECDISYHIYCVNPPLETVPTGNWKC-------------SFCTLCQKCGRNPT 636
              |...|::||  :|..:||:.|:|  |...|.|.|:|             |||..|........
Human  1329 --DGGELVMCDKKDCPKAYHLLCLN--LTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDH 1389

  Fly   637 EKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHC 685
            ||.....| .||...|.|:.. |:..||            .|.|:...|
Human  1390 EKGALVPS-ALEGRLCCSEHD-PMAPVS------------PEYWSKIKC 1424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984	20/45 (44%)
		PHD2_KMT2C_like	252..298	CDD:276985	14/71 (20%)
		PHD_SF	337..392	CDD:304600	21/157 (13%)
		PHD4_KMT2C_like	530..578	CDD:276987	10/47 (21%)
		PHD5_KMT2C_like	580..625	CDD:276988	18/59 (31%)
		PHD6_KMT2C_like	657..707	CDD:276989	6/29 (21%)
		NHP6B	1101..>1237	CDD:227935
		HMG	1173..1231	CDD:197700
NSD3	NP_075447.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..157
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	181..252
		PWWP domain; Pfam PF00855	264..324
		MSH6_like	267..383	CDD:99898
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..365
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	406..465
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	540..696
		TNG2	<602..746	CDD:227367	21/51 (41%)
		PHD type zinc finger motif	697..738		19/41 (46%)
		PHD1_NSD3	703..746	CDD:277119	20/46 (43%)
		PHD type zinc finger motif	745..795		13/50 (26%)
		PHD2_NSD3	751..797	CDD:277122	13/46 (28%)
		PHD3_NSD3	798..850	CDD:277125	10/53 (19%)
		PHD type zinc finger motif	858..945		15/87 (17%)
		PHD4_NSD3	917..952	CDD:277128	5/34 (15%)
		PWWP domain; Pfam PF00855	954..1013		6/58 (10%)
		WHSC1_related	958..1051	CDD:99899	12/92 (13%)
		AWS	1094..1144	CDD:197795	5/53 (9%)
		SET	1145..1268	CDD:214614	21/122 (17%)
		SET domain	1149..1255		17/105 (16%)
		PHD type zinc finger motif	1317..1364		17/51 (33%)
		PHD5_NSD3	1323..1365	CDD:277131	17/46 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030