DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and Crebbp

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:XP_038942595.1 Gene:Crebbp / 54244 RGDID:2401 Length:2454 Species:Rattus norvegicus


Alignment Length:1361 Identity:248/1361 - (18%)
Similarity:425/1361 - (31%) Gaps:471/1361 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   373 TAYHKKKEQNP------DYDYVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSSEQLSLKEIELDPL 431
            |..|.:....|      ..|...|...|.:|...||||....:.:..|.:   ::...:.|.||.
  Rat   951 TPVHTQPPGTPLSQAAASIDNRVPTPSSVTSAETSSQQPGPDVPMLEMKT---EVQTDDAEPDPA 1012

  Fly   432 E--GKPTMDPSSDELHKLPTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKG------- 487
            |  |:|..:...::|......|::...|..:....:....:..|..:..::......|       
  Rat  1013 ESKGEPRSEMMEEDLQGSSQVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSANGTASQSTS 1077

  Fly   488 --------------RQLALPTISSDRCLSRSMETDL---------------------------TS 511
                          ||..:||:.:   |.|.....|                           |.
  Rat  1078 PSQPRKKIFKPEELRQALMPTLEA---LYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTI 1139

  Fly   512 DKKLLLCSARDKFIQAQDICVMCGSLGI---ESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGW 573
            .:||.....::.:....|:.:|..:..:   ::..|...|::..:.:......|..|.|      
  Rat  1140 KRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLG------ 1198

  Fly   574 RCLDCTVCEGCGKKNDEARLLLCDEC----------DISYHIYCVNPPLETVPTGNWKCSFCTLC 628
                  .|  ||:|.:.:...||  |          |.:|:.|..:.|...:....:.     .|
  Rat  1199 ------YC--CGRKYEFSPQTLC--CYGKQLCTIPRDAAYYSYQNSSPKYGLLADRYH-----FC 1248

  Fly   629 QKC-----GRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYS-------NGEMIIQCEHCELWA 681
            :||     |.|.|    .||.        .||....:.|..:.       :.|..:.|:.|....
  Rat  1249 EKCFTEIQGENVT----LGDD--------PSQPQTTISKDQFEKKKNDTLDPEPFVDCKECGRKM 1301

  Fly   682 HFHCDSVNAQLTIDHYD---NNVYKCFKCRCSTR--------STNSLADAKFGN--EDSL----- 728
            |        |:.:.|||   .:.:.|..|...|.        |...|...:.||  ||.:     
  Rat  1302 H--------QICVLHYDIIWPSGFVCDNCLKKTGRPRKENKFSAKRLQTTRLGNHLEDRVNKFLR 1358

  Fly   729 -AITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMPESAPE------ALHWIDGVCLSESG 786
             ...|:..:.||.:.|||..:.:.|.|.:..... ||:|.||.|.      |...||||.:...|
  Rat  1359 RQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVD-SGEMSESFPYRTKALFAFEEIDGVDVCFFG 1422

  Fly   787 LGM----------------IKSL-STEIKRKRKMRQALGNGKDGQLEAAAEEALEK--YKDGMVW 832
            :.:                |..| |....|.|.:|.|:.:    ::.....|.::|  |..|.:|
  Rat  1423 MHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVYH----EILIGYLEYVKKLGYVTGHIW 1483

  Fly   833 DGTENAIP--EG--FTISINDEGVNILRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTAVDQINS 893
                 |.|  ||  :....:.....|.:.||   ||:           ..||..::..|...||.
  Rat  1484 -----ACPPSEGDDYIFHCHPPDQKIPKPKR---LQE-----------WYKKMLDKAFAERIIND 1529

  Fly   894 LMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPE 958
            .      |.|.::..:::|..|..:...|..|...:||         :|..|::...:   .|.:
  Rat  1530 Y------KDIFKQANEDRLTSAKELPYFEGDFWPNVLE---------ESIKELEQEEE---ERKK 1576

  Fly   959 GKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKNGTTP-VSNVFDPLQAEIS 1022
            .:|.|..:|...::..:|..||...:...:||:        .|...|...| :.||.:.|..::.
  Rat  1577 EESTAASETPEGSQGDSKNAKKKNNKKTNKNKS--------SISRANKKKPSMPNVSNDLSQKLY 1633

  Fly  1023 NTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLV-------DSFMVPNQLP 1080
            .|:..::.....:      .|.....:||.|       |:.:...:|.       |:|:.   |.
  Rat  1634 ATMEKHKEVFFVI------HLHAGPVISTQP-------PIVDPDPLLSCDLMDGRDAFLT---LA 1682

  Fly  1081 QEQ--KFHNQLYLGGNT---LVNPAQQLQFRQQAPQNANKQNMQTIMSQVVLQ------------ 1128
            :::  :|.:......:|   ||....|.|.|.....|..|.:::|.....|.:            
  Rat  1683 RDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTK 1747

  Fly  1129 --TEKR-------PEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLY------ANT 1178
              |.|.       .:|.....||        ..|:.::.|:   |.:...|.::::      ||.
  Rat  1748 SHTHKMVKWGLGLDDEGSSQGEP--------QSKSPQESRR---LSIQRCIQSLVHACQCRNANC 1801

  Fly  1179 EHPNLKEL-----------------FPIWNDRCKQILKRWRSLC---------NEKKAPFLQKAK 1217
            ..|:.:::                 .|:    |||::    :||         |:...||....|
  Rat  1802 SLPSCQKMKRVVQHTKGCKRKTNGGCPV----CKQLI----ALCCYHAKHCQENKCPVPFCLNIK 1858

  Fly  1218 DNRSALRQRREQNKI----------------------------------------PMPPKPQKQE 1242
            ..   |||::.|:::                                        |..|:|..|.
  Rat  1859 HK---LRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQP 1920

  Fly  1243 EMGRVWKQP---PKLKEDQPNMFVTYNGNAYDMGNYVGGSAQAASNNPNPHHVMPNVNDNLVIKA 1304
            :...|...|   |.:...||...|:           .|.........|.|....|     ..::|
  Rat  1921 QPSPVNMSPAGFPSVARTQPPTIVS-----------AGKPTNQVPAPPPPAQPPP-----AAVEA 1969

  Fly  1305 TMQ-----RTQVHTTAASTLKMTTVDNRLELNTAVYGT-----EPIGDKKLRNLLQKNSTEPMLM 1359
            ..|     :.|.|      |....::|.:....|..||     .|:|    .|:.:.|.....:|
  Rat  1970 ARQIEREAQQQQH------LYRANINNGMPPGRAGMGTPGSQMAPVG----LNVPRPNQVSGPVM 2024

  Fly  1360 GANSDLFLGNDVMRLGMMQNTPITQNNPM-------------LSISGKSQPSEGRSLEQDVKLGE 1411
            .:          |..|..|..||.|..||             .:::|...|:          :..
  Rat  2025 SS----------MPPGQWQQAPIPQQQPMPGMPRPVMSMQAQAAVAGPRMPN----------VQP 2069

  Fly  1412 PQEATSSAVELENVGFSDLLGGLGEGDDDDLLKSLTSEMGDDFNILEYADPELDVNVLNSL 1472
            |:..:.||::                   |||::|.|.          :.|:....|||.|
  Rat  2070 PRSISPSALQ-------------------DLLRTLKSP----------SSPQQQQQVLNIL 2101

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135
PHD1_KMT2C_like 205..250 CDD:276984
PHD2_KMT2C_like 252..298 CDD:276985
PHD_SF 337..392 CDD:304600 5/24 (21%)
PHD4_KMT2C_like 530..578 CDD:276987 6/50 (12%)
PHD5_KMT2C_like 580..625 CDD:276988 11/54 (20%)
PHD6_KMT2C_like 657..707 CDD:276989 10/59 (17%)
NHP6B 1101..>1237 CDD:227935 34/228 (15%)
HMG 1173..1231 CDD:197700 17/89 (19%)
CrebbpXP_038942595.1 zf-TAZ 362..429 CDD:396624
KIX 586..666 CDD:366953
PHA03247 <682..1098 CDD:223021 25/149 (17%)
COG5076 942..>1194 CDD:227408 37/248 (15%)
Bromo_cbp_like 1088..1195 CDD:99927 15/109 (14%)
RING_CBP-p300 1207..1289 CDD:276805 18/100 (18%)
PHD_CBP_p300 1291..1322 CDD:277032 8/38 (21%)
HAT_KAT11 1353..1660 CDD:400497 76/369 (21%)
ZZ_CBP 1716..1756 CDD:239077 6/39 (15%)
zf-TAZ 1783..1851 CDD:396624 11/75 (15%)
Med15 1971..>2425 CDD:312941 36/190 (19%)
Creb_binding 2045..2123 CDD:401102 15/96 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5076
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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