DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lpt and PHF20

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:NP_057520.2 Gene:PHF20 / 51230 HGNCID:16098 Length:1012 Species:Homo sapiens


Alignment Length:773 Identity:135/773 - (17%)
Similarity:231/773 - (29%) Gaps:303/773 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   349 HKEMVKCSWCNKFVHSTCDEEADLTAYHKK----------KEQNPDYDYVCPNCKSNSSGPGSSQ 403
            ||...|...|.||.     .:|.|..||.|          .|::|...:|.....|.|..|  ||
Human   450 HKFRCKVVDCLKFF-----RKAKLLHYHMKYFHGMEKSLEPEESPGKRHVQTRGPSASDKP--SQ 507

  Fly   404 QTIDSIVLSAMD------SSSEQLSLKE-IELDPLEGKPTMD------PSSDEL---HKLPTGKK 452
            :|:....:||..      ..:::...|| :.:.|.:.|....      |.|:|:   .:.|:..|
Human   508 ETLTRKRVSASSPTTKDKEKNKEKKFKEFVRVKPKKKKKKKKKTKPECPCSEEISDTSQEPSPPK 572

  Fly   453 KVCLTSVRGRSGKFVLHRMGV-MS-QINKKRSTRGKGRQLALPTISSDRCLSRSMETDLTSDKKL 515
            ...:|    |.|.  .|:.|| || |::...|...||:..||   ..|.....|.|:.|.||   
Human   573 AFAVT----RCGS--SHKPGVHMSPQLHGPESGHHKGKVKAL---EEDNLSESSSESFLWSD--- 625

  Fly   516 LLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTV 580
                  |::  .||:                                              |.|.
Human   626 ------DEY--GQDV----------------------------------------------DVTT 636

  Fly   581 CEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFGDSN 645
                                                                 ||.|:.:..|..
Human   637 -----------------------------------------------------NPDEELDGDDRY 648

  Fly   646 MLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNV---YKCFKC 707
            ..|...|       :|:|...| :.:||||.|:.|.|..|..:        .:.||   |.|:.|
Human   649 DFEVVRC-------ICEVQEEN-DFMIQCEECQCWQHGVCMGL--------LEENVPEKYTCYVC 697

  Fly   708 RCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMPESAPE 772
            :                                                        |.|...|.
Human   698 Q--------------------------------------------------------DPPGQRPG 706

  Fly   773 ALHWIDGVCLSES---GLGMIKSLSTEIKRKR--KMRQALGNGKDGQLEAAAEEALEKYKDGMVW 832
            ..:|.|...||..   ||..::...:....|:  ...|.||:         .:..:|        
Human   707 FKYWYDKEWLSRGHMHGLAFLEENYSHQNAKKIVATHQLLGD---------VQRVIE-------- 754

  Fly   833 DGTENAIPEGFTISINDEGVNILRKKRQRNL--------QKLGIGGFSVRNRGL--KKDSEETTA 887
                  :..|..:.     ::||:.:...:|        |..|.|....||..:  .:..||..:
Human   755 ------VLHGLQLK-----MSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPS 808

  Fly   888 VDQINSLMTMDKKKKII----RKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDA 948
            ...:|.  .::|.:.:.    |..:::.:...:......|::  |.:|  :.::.:|..|...||
Human   809 YRTLNG--AVEKPRPLALPLPRSVEESYITSEHCYQKPRAYY--PAVE--QKLVVETRGSALDDA 867

  Fly   949 SMKVYFTRPEGKS-----PANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQMP-MGIQNKNGT 1007
            ...::....:..|     |.:||....:..|.....|||..:   :|....::.| ..:.::.|.
Human   868 VNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYV---SKKALPEEAPARKLLDRGGE 929

  Fly  1008 TPVSNV----------FDPLQAEISNTVFANRHPLDALAS--PNVPELDMANSVSTVP 1053
            ..:|:.          .:.||.|:::.:.:....||.|.|  ....||:....::.:|
Human   930 GLLSSQHQWQFNLLTHVESLQDEVTHRMDSIEKELDVLESWLDYTGELEPPEPLARLP 987

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135
PHD1_KMT2C_like 205..250 CDD:276984
PHD2_KMT2C_like 252..298 CDD:276985
PHD_SF 337..392 CDD:304600 14/52 (27%)
PHD4_KMT2C_like 530..578 CDD:276987 0/47 (0%)
PHD5_KMT2C_like 580..625 CDD:276988 0/44 (0%)
PHD6_KMT2C_like 657..707 CDD:276989 15/52 (29%)
NHP6B 1101..>1237 CDD:227935
HMG 1173..1231 CDD:197700
PHF20NP_057520.2 MBT 3..68 CDD:302657
TUDOR 90..135 CDD:119391
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 142..336
DUF3776 176..259 CDD:289391
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..611 34/140 (24%)
PHD_PHF20 654..697 CDD:277104 16/58 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 866..912 10/48 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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