DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Kmt2c

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_038964891.1	Gene:	Kmt2c / 502710	RGDID:	1587205	Length:	5003	Species:	Rattus norvegicus

Alignment Length:	1733	Identity:	439/1733 - (25%)
Similarity:	659/1733 - (38%)	Gaps:	556/1733 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STNVVVSMEEKAVADDLPY------FPEKFPGKVCCLCNLGEKSALGQGEILQLKA--------- 51
            |:....|..:::|::|..:      ...|...::|..|..||||:||||::.|.:.
  Rat   101 SSKQPASALQRSVSEDSAHSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRVTPGLTLPWK 165

  Fly    52 --PAPAEIKDK--YPTDRLREDGSRLLYGPKQAAS-------------------SSGDCHYELDK 93
              |:..::.|.  ...::::....|...|.::..|                   ..|....||..
  Rat   166 DQPSNKDVGDSGIATCEKIQNYAPRKQRGQRKERSLQQSIVSCVSVSTQTACEDQPGKLWDELSL 230

  Fly    94 IGQPDVVHPAEFLDE-GFVYVHRMCIMWSLRKSQISD-----ADGAYFATHFAEFLEQKCNFCGR 152
            :|.||.:......|. |..:.|..|:.|||...|:.:     .|.|..:..     .::|.||..
  Rat   231 VGLPDAIDVQALFDSTGTCWAHHRCVEWSLGICQMEEPLLVNVDKAVVSGS-----TERCAFCKH 290

  Fly   153 YGASIN-CKMNCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSLGDLS 216
            .||:|. |:..|.|::|:||||.||.......|.:.|.||:.|.|. .|..:..|..|.|.|||.
  Rat   291 LGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHFFLLCPEHIDQAPE-RSKEDANCAVCDSPGDLL 354

  Fly   217 KLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKCEQCQKTYHASCL 281
            ....|:|||.|:|..|:.:|..|..|:||.|..|..||.|| |...|:|.:.|:.|.|.||..||
  Rat   355 DQFFCTTCGQHYHGMCLDIAVTPLRRAGWQCPECKVCQNCR-QSGEDSKMLVCDTCDKGYHTFCL 418

  Fly   282 RPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPICQKAYRA 346
            :||:.::|..||||..||:|.:||:|     ||::||.:..|||:|.||::.  .||.|.|.|..
  Rat   419 QPVMKSVPTNGWKCKNCRICIECGTR-----SSAQWHHNCLICDTCNQQQDN--LCPFCGKCYHP 476

  Fly   347 ASHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCK------------------ 393
            ...|:|:.|:.|.::||..||:..|.....:.||     :|:|..||
  Rat   477 ELQKDMLHCNMCKRWVHLECDKPTDQELDSQLKE-----EYICMYCKHLGAEIDPLHPGNEVEMP 536

  Fly   394 -----SNSSG---PGSS------QQTI----------------------------------DSIV 410
                 .:|||   .|:.      :||:                                  |::.
  Rat   537 ELLPTDDSSGMEIEGTEDEVVFLEQTVNEDVSGHQSPPGIVPDAVQVYTEEPQKSDPLESPDTVG 601

  Fly   411 LSAMDSSS-------------------------------------------------EQLSLKEI 426
            |...:||.                                                 .|..:.:.
  Rat   602 LITSESSENKTNPDLANEISHEVDTEKTEMFYKEGLVCEEDQSEDRMEVTENIEVLPHQTIVPQE 666

  Fly   427 ELDPLEGK------------------------------------------------------PT- 436
            ||.|.||.                                                      ||
  Rat   667 ELLPSEGSEVAPEEPSPSESAVELAAPEALVSPHSESSLSHKGPLVIERVQEEMEQKENSEFPTG 731

  Fly   437 ---------MD---------------------------------------------PSSDELHKL 447
                     :|                                             ||.|.||..
  Rat   732 CEDFEMTLAVDGCVKGSSCQGDKSAELPAEEESPFSSGTDLNKADVSSSSTLRPDLPSCDMLHGY 796

  Fly   448 PTG----------------------------KKKVCLTSVRGRSGKFVLH--------------- 469
            |:.                            |:|......|.:.|.:..|
  Rat   797 PSAFNSAAGSVMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSNHNTVSPPSWSPDIAEG 861

  Fly   470 -----------------RMGVMSQINKKRSTR--------GKGRQ--------LALPTISSDRCL 501
                             ::|..|....||..|        |:||.        :.||.:|:....
  Rat   862 REIFKPRQLSGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGRSKLKSGLGAVVLPGVSAADIS 926

  Fly   502 SRSMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSR 566
            |...|.:.:....::|.|:.|||...||:||:|||.|...:..::.|:||||||||||..:|.::
  Rat   927 SNKDEEENSMHNTVVLFSSSDKFTLHQDMCVVCGSFGQGEEGRLLACSQCGQCYHPYCVSIKITK 991

  Fly   567 GILQKGWRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKC 631
            .:|.||||||:|||||.|||..|..||||||:||||||.||::|||:|||.|.|||.:|..|:.|
  Rat   992 VVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHC 1056

  Fly   632 GRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDH 696
            |...........:|..:|..|.|.||||||..:|...::|:||..|:.|.|..|.::|.:..:::
  Rat  1057 GATSAGLRCEWQNNYTQCAPCASLSSCPVCCRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVEN 1121

  Fly   697 YDNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHIT-ASSGPSFDSKSGAERNHP 760
            ..:..:.|..||                            |::.:: ..|....||...|:
  Rat  1122 VADIGFDCSMCR----------------------------PYMPVSNVPSSDCCDSSLVAQ---- 1154

  Fly   761 TLSGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQAL------------------ 807
             :...:.|..|...:..|||||:|||:..::||:....|:::.:..|
  Rat  1155 -IVTKVKELDPPKTYTQDGVCLTESGMSQLQSLTVTAPRRKRTKPKLKLKIINQNSVAVLQTPPD 1218

  Fly   808 ---GNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPE---GFTISINDEGVNILRKKRQRNLQKL 866
               .:.:||:::.:.|..|      |..||...:.||   |...:...||.:.: |||:|...:.
  Rat  1219 IQSEHSRDGEMDDSREGEL------MDCDGKSESSPEREAGDDETKGIEGTDGV-KKRKRKPYRP 1276

  Fly   867 GIGGFSVRNRG-----------LKKDSEET------------------TAVDQINSLMTMDKKKK 902
            |||||.||.|.           ::|||..:                  |.||:..|:....:|.|
  Rat  1277 GIGGFMVRQRSRTGQGKAKRSVVRKDSSGSISEQLSNRDDGWREQFPDTLVDEPVSVADSTEKIK 1341

  Fly   903 IIRKKQKNKLIEAYPVYLQEAFFGKPLLEGG--ELVMADTDSSDEIDASMKVYFTRP-------E 958
            ...:|:||||.|.:|.|||||||||.||:..  ..:..|..|.|....|.|..|..|       .
  Rat  1342 KRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQNKLSVDNLSEDAAQLSYKTGFMDPSSDPLLCS 1406

  Fly   959 GKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFI--QQMPMGIQNKN--------GTTPVSNV 1013
            ..:.|...|......|...:.:|   |.|::..:.|  ..:...:.:..        |::|....
  Rat  1407 SSASAKPGTQGTADDPLADISEV---LNTDDDILGIISDDLAKSVDHSGLDLCTFQVGSSPFPLD 1468

  Fly  1014 FDPLQAEISN----TVFANRHP-----LDALASP----------------NVPEL------DMAN 1047
            ..|:..:.|:    :|..:..|     |||:.||                .:|||      |:..
  Rat  1469 IGPIADDASSLPQPSVSQSSRPLSEEQLDAILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFT 1533

  Fly  1048 SV----STVPSAEVIEKPMRESPAVLVDSFM---VPNQL--PQEQKFHNQLYLGGNTLVNPA--- 1100
            :|    .|.|:......|.:..|....|.|.   :.|.|  |.....|:.|..|......||
  Rat  1534 AVLSPAPTQPAPLPQPPPPQPLPVHTQDVFSRMPLMNGLIGPSPHLPHHSLPAGSALGTFPAIAQ 1598

  Fly  1101 --------QQLQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEK 1157
                    :.|.|...| .:||...:.|..|                :|...::| :..|::..|
  Rat  1599 SPYTDVRDKSLAFNVMA-SDANSSWVPTAPS----------------MEGENDSL-SNAQRSTLK 1645

  Fly  1158 MRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSA 1222
            ..|:|.||.:||::.|||.|...|||||.||.|..|.|||.|.||...::::||::|||:|||:|
  Rat  1646 WEKEEALGEVATVAPVLYTNINFPNLKEEFPDWTTRVKQIAKLWRKASSQERAPYVQKARDNRAA 1710

  Fly  1223 LRQRREQNKIPMPPKPQKQEEM-------GRVWKQPPKLKEDQ 1258
            ||..:.|.......:.|:|:.:       ..::|.|.|.:|.:
  Rat  1711 LRINKVQMSNDSMKRQQQQDSIDPTSRIDSDLFKDPLKQRESE 1753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135	27/87 (31%)
		PHD1_KMT2C_like	205..250	CDD:276984	19/44 (43%)
		PHD2_KMT2C_like	252..298	CDD:276985	21/45 (47%)
		PHD_SF	337..392	CDD:304600	18/54 (33%)
		PHD4_KMT2C_like	530..578	CDD:276987	25/47 (53%)
		PHD5_KMT2C_like	580..625	CDD:276988	31/44 (70%)
		PHD6_KMT2C_like	657..707	CDD:276989	15/49 (31%)
		NHP6B	1101..>1237	CDD:227935	48/135 (36%)
		HMG	1173..1231	CDD:197700	31/57 (54%)
Kmt2c	XP_038964891.1	ePHD1_KMT2C	247..330	CDD:277166	27/87 (31%)
		PHD1_KMT2C_like	343..388	CDD:276984	19/44 (43%)
		PHD2_KMT2C	390..435	CDD:277069	21/45 (47%)
		PHD3_KMT2C	466..517	CDD:276986	18/55 (33%)
		PHD_SF	948..1004	CDD:419867	29/55 (53%)
		PHD5_KMT2C_like	1005..1051	CDD:276988	31/45 (69%)
		RanBP2-type Zn finger	1080..1102	CDD:275375	10/21 (48%)
		PHD6_KMT2C	1082..1132	CDD:277073	15/49 (31%)
		HMG	1659..1712	CDD:197700	28/52 (54%)
		PHA03247	<1901..2381	CDD:223021
		Atrophin-1	<2439..>2692	CDD:397323
		MDN1	<2694..2955	CDD:227596
		Myosin_tail_1	<3202..>3284	CDD:396244
		PHA03247	<3314..3677	CDD:223021
		ePHD2_KMT2C	4494..4598	CDD:277167
		FYRN	4643..4694	CDD:399155
		FYRC	4700..4784	CDD:399156
		SET_KMT2C_2D	4850..5002	CDD:380948
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352841
Domainoid	1	1.000	61	1.000	Domainoid score	I10286
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39671at33208
OrthoFinder	1	1.000	-	-		FOG0002860
OrthoInspector	1	1.000	-	-		oto97062
orthoMCL	1	0.900	-	-		OOG6_102575
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.750