DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and Kmt2c

DIOPT Version :10

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:XP_038964891.1 Gene:Kmt2c / 502710 RGDID:1587205 Length:5003 Species:Rattus norvegicus


Alignment Length:1733 Identity:439/1733 - (25%)
Similarity:659/1733 - (38%) Gaps:556/1733 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 STNVVVSMEEKAVADDLPY------FPEKFPGKVCCLCNLGEKSALGQGEILQLKA--------- 51
            |:....|..:::|::|..:      ...|...::|..|..||||:||||::.|.:.         
  Rat   101 SSKQPASALQRSVSEDSAHSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRVTPGLTLPWK 165

  Fly    52 --PAPAEIKDK--YPTDRLREDGSRLLYGPKQAAS-------------------SSGDCHYELDK 93
              |:..::.|.  ...::::....|...|.::..|                   ..|....||..
  Rat   166 DQPSNKDVGDSGIATCEKIQNYAPRKQRGQRKERSLQQSIVSCVSVSTQTACEDQPGKLWDELSL 230

  Fly    94 IGQPDVVHPAEFLDE-GFVYVHRMCIMWSLRKSQISD-----ADGAYFATHFAEFLEQKCNFCGR 152
            :|.||.:......|. |..:.|..|:.|||...|:.:     .|.|..:..     .::|.||..
  Rat   231 VGLPDAIDVQALFDSTGTCWAHHRCVEWSLGICQMEEPLLVNVDKAVVSGS-----TERCAFCKH 290

  Fly   153 YGASIN-CKMNCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSLGDLS 216
            .||:|. |:..|.|::|:||||.||.......|.:.|.||:.|.|. .|..:..|..|.|.|||.
  Rat   291 LGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHFFLLCPEHIDQAPE-RSKEDANCAVCDSPGDLL 354

  Fly   217 KLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKCEQCQKTYHASCL 281
            ....|:|||.|:|..|:.:|..|..|:||.|..|..||.|| |...|:|.:.|:.|.|.||..||
  Rat   355 DQFFCTTCGQHYHGMCLDIAVTPLRRAGWQCPECKVCQNCR-QSGEDSKMLVCDTCDKGYHTFCL 418

  Fly   282 RPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPICQKAYRA 346
            :||:.::|..||||..||:|.:||:|     ||::||.:..|||:|.||::.  .||.|.|.|..
  Rat   419 QPVMKSVPTNGWKCKNCRICIECGTR-----SSAQWHHNCLICDTCNQQQDN--LCPFCGKCYHP 476

  Fly   347 ASHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCK------------------ 393
            ...|:|:.|:.|.::||..||:..|.....:.||     :|:|..||                  
  Rat   477 ELQKDMLHCNMCKRWVHLECDKPTDQELDSQLKE-----EYICMYCKHLGAEIDPLHPGNEVEMP 536

  Fly   394 -----SNSSG---PGSS------QQTI----------------------------------DSIV 410
                 .:|||   .|:.      :||:                                  |::.
  Rat   537 ELLPTDDSSGMEIEGTEDEVVFLEQTVNEDVSGHQSPPGIVPDAVQVYTEEPQKSDPLESPDTVG 601

  Fly   411 LSAMDSSS-------------------------------------------------EQLSLKEI 426
            |...:||.                                                 .|..:.:.
  Rat   602 LITSESSENKTNPDLANEISHEVDTEKTEMFYKEGLVCEEDQSEDRMEVTENIEVLPHQTIVPQE 666

  Fly   427 ELDPLEGK------------------------------------------------------PT- 436
            ||.|.||.                                                      || 
  Rat   667 ELLPSEGSEVAPEEPSPSESAVELAAPEALVSPHSESSLSHKGPLVIERVQEEMEQKENSEFPTG 731

  Fly   437 ---------MD---------------------------------------------PSSDELHKL 447
                     :|                                             ||.|.||..
  Rat   732 CEDFEMTLAVDGCVKGSSCQGDKSAELPAEEESPFSSGTDLNKADVSSSSTLRPDLPSCDMLHGY 796

  Fly   448 PTG----------------------------KKKVCLTSVRGRSGKFVLH--------------- 469
            |:.                            |:|......|.:.|.:..|               
  Rat   797 PSAFNSAAGSVMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSNHNTVSPPSWSPDIAEG 861

  Fly   470 -----------------RMGVMSQINKKRSTR--------GKGRQ--------LALPTISSDRCL 501
                             ::|..|....||..|        |:||.        :.||.:|:....
  Rat   862 REIFKPRQLSGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGRSKLKSGLGAVVLPGVSAADIS 926

  Fly   502 SRSMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSR 566
            |...|.:.:....::|.|:.|||...||:||:|||.|...:..::.|:||||||||||..:|.::
  Rat   927 SNKDEEENSMHNTVVLFSSSDKFTLHQDMCVVCGSFGQGEEGRLLACSQCGQCYHPYCVSIKITK 991

  Fly   567 GILQKGWRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKC 631
            .:|.||||||:|||||.|||..|..||||||:||||||.||::|||:|||.|.|||.:|..|:.|
  Rat   992 VVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHC 1056

  Fly   632 GRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDH 696
            |...........:|..:|..|.|.||||||..:|...::|:||..|:.|.|..|.::|.:..:::
  Rat  1057 GATSAGLRCEWQNNYTQCAPCASLSSCPVCCRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVEN 1121

  Fly   697 YDNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHIT-ASSGPSFDSKSGAERNHP 760
            ..:..:.|..||                            |::.:: ..|....||...|:    
  Rat  1122 VADIGFDCSMCR----------------------------PYMPVSNVPSSDCCDSSLVAQ---- 1154

  Fly   761 TLSGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQAL------------------ 807
             :...:.|..|...:..|||||:|||:..::||:....|:::.:..|                  
  Rat  1155 -IVTKVKELDPPKTYTQDGVCLTESGMSQLQSLTVTAPRRKRTKPKLKLKIINQNSVAVLQTPPD 1218

  Fly   808 ---GNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPE---GFTISINDEGVNILRKKRQRNLQKL 866
               .:.:||:::.:.|..|      |..||...:.||   |...:...||.:.: |||:|...:.
  Rat  1219 IQSEHSRDGEMDDSREGEL------MDCDGKSESSPEREAGDDETKGIEGTDGV-KKRKRKPYRP 1276

  Fly   867 GIGGFSVRNRG-----------LKKDSEET------------------TAVDQINSLMTMDKKKK 902
            |||||.||.|.           ::|||..:                  |.||:..|:....:|.|
  Rat  1277 GIGGFMVRQRSRTGQGKAKRSVVRKDSSGSISEQLSNRDDGWREQFPDTLVDEPVSVADSTEKIK 1341

  Fly   903 IIRKKQKNKLIEAYPVYLQEAFFGKPLLEGG--ELVMADTDSSDEIDASMKVYFTRP-------E 958
            ...:|:||||.|.:|.|||||||||.||:..  ..:..|..|.|....|.|..|..|       .
  Rat  1342 KRYRKRKNKLEETFPAYLQEAFFGKDLLDTSRQNKLSVDNLSEDAAQLSYKTGFMDPSSDPLLCS 1406

  Fly   959 GKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFI--QQMPMGIQNKN--------GTTPVSNV 1013
            ..:.|...|......|...:.:|   |.|::..:.|  ..:...:.:..        |::|....
  Rat  1407 SSASAKPGTQGTADDPLADISEV---LNTDDDILGIISDDLAKSVDHSGLDLCTFQVGSSPFPLD 1468

  Fly  1014 FDPLQAEISN----TVFANRHP-----LDALASP----------------NVPEL------DMAN 1047
            ..|:..:.|:    :|..:..|     |||:.||                .:|||      |:..
  Rat  1469 IGPIADDASSLPQPSVSQSSRPLSEEQLDAILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFT 1533

  Fly  1048 SV----STVPSAEVIEKPMRESPAVLVDSFM---VPNQL--PQEQKFHNQLYLGGNTLVNPA--- 1100
            :|    .|.|:......|.:..|....|.|.   :.|.|  |.....|:.|..|......||   
  Rat  1534 AVLSPAPTQPAPLPQPPPPQPLPVHTQDVFSRMPLMNGLIGPSPHLPHHSLPAGSALGTFPAIAQ 1598

  Fly  1101 --------QQLQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEK 1157
                    :.|.|...| .:||...:.|..|                :|...::| :..|::..|
  Rat  1599 SPYTDVRDKSLAFNVMA-SDANSSWVPTAPS----------------MEGENDSL-SNAQRSTLK 1645

  Fly  1158 MRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSA 1222
            ..|:|.||.:||::.|||.|...|||||.||.|..|.|||.|.||...::::||::|||:|||:|
  Rat  1646 WEKEEALGEVATVAPVLYTNINFPNLKEEFPDWTTRVKQIAKLWRKASSQERAPYVQKARDNRAA 1710

  Fly  1223 LRQRREQNKIPMPPKPQKQEEM-------GRVWKQPPKLKEDQ 1258
            ||..:.|.......:.|:|:.:       ..::|.|.|.:|.:
  Rat  1711 LRINKVQMSNDSMKRQQQQDSIDPTSRIDSDLFKDPLKQRESE 1753

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135 27/87 (31%)
PHD1_KMT2C_like 205..250 CDD:276984 19/44 (43%)
PHD2_KMT2C_like 252..298 CDD:276985 21/45 (47%)
PHD_SF 337..392 CDD:473978 18/54 (33%)
PHD4_KMT2C_like 530..578 CDD:276987 25/47 (53%)
PHD5_KMT2C_like 580..625 CDD:276988 31/44 (70%)
PHD6_KMT2C_like 657..707 CDD:276989 15/49 (31%)
NHP6B 1101..>1237 CDD:227935 48/135 (36%)
HMG_KMT2C-like 1157..1223 CDD:438813 34/65 (52%)
Kmt2cXP_038964891.1 ePHD1_KMT2C 247..330 CDD:277166 27/87 (31%)
PHD1_KMT2C_like 343..388 CDD:276984 19/44 (43%)
PHD2_KMT2C 390..435 CDD:277069 21/45 (47%)
PHD3_KMT2C 466..517 CDD:276986 18/55 (33%)
PHD_SF 948..1004 CDD:473978 29/55 (53%)
PHD5_KMT2C_like 1005..1051 CDD:276988 31/45 (69%)
RanBP2-type Zn finger 1080..1102 CDD:275375 10/21 (48%)
PHD6_KMT2C 1082..1132 CDD:277073 15/49 (31%)
HMG-box_KMT2C 1640..1720 CDD:438835 39/79 (49%)
PHA03247 <1901..2381 CDD:223021
Atrophin-1 2241..>2693 CDD:460830
TPH <3197..>3282 CDD:464007
PHA03247 <3314..3677 CDD:223021
ePHD2_KMT2C 4494..4598 CDD:277167
FYRN 4643..4694 CDD:461787
FYRC 4700..4784 CDD:461788
SET_KMT2C_2D 4850..5002 CDD:380948
Blue background indicates that the domain is not in the aligned region.

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