DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpt and Cecr2

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_008761473.1	Gene:	Cecr2 / 500308	RGDID:	1564182	Length:	1465	Species:	Rattus norvegicus

Alignment Length:	729	Identity:	132/729 - (18%)
Similarity:	222/729 - (30%)	Gaps:	261/729 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   911 KLIEAYPVYLQEAFF-GKPLLEGGELV--MAD--TDSSDEIDA-------SMKV----------- 952
            :|.|..|..|:||.| ..||....|::  :.|  .|:.|..|.       |::|
  Rat    91 ELEEGKPNPLREASFQDLPLRTRVEILHRLCDYRLDADDVFDLLKGLDADSLRVEPLGEDNSGAL 155

  Fly   953 ----YFTRPEGKSPA-------------NQDTLAVNKSPAKTVKK--------------VKAELK 986
                |.||...:.|.             ::....|:..|.||.|:              :.:|.:
  Rat   156 YWYFYGTRMYKEDPVQGRSNGELSLSRESERQKNVSNVPGKTGKRRGRPPKRKKLQEEIISSEKQ 220

  Fly   987 TENKTVFIQQMPMGIQNKNGT------------------TPVSNVF----------------DPL 1017
            .||      .:...:|.:||:                  ..|:..|                :..
  Rat   221 EEN------SLTSDLQTRNGSRGPGQGTWWLLCQTEEEWRQVTESFRERTSLRERQLYKLLSEDF 279

  Fly  1018 QAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQE 1082
            ..||.|.: |.:........|.:....|::.:| :.|.::.|.||...         :..|..:|
  Rat   280 LPEICNMI-AQKGKRPQRTKPELQHRFMSDHLS-IKSTKLEETPMLTK---------IEKQKRKE 333

  Fly  1083 QKFHNQLYLGGNTLVNPAQQLQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQ--------KV 1139
            ::...||.|        |.|.:.::|..:...|:.::..:..|..:.::|...|:        |.
  Rat   334 EEEERQLLL--------AVQKKEQEQMLKEERKRELEEKVKAVEDRAKRRKLREERAWLLAQGKE 390

  Fly  1140 VEPVTETLNAGT-----QKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILK 1199
            :.|....|:..:     :||.:....|:|...|..:..|:.|:.:
  Rat   391 LPPELSHLDLNSPMREGKKTKDIFELDDDFTAMYKVLDVVKAHKD-------------------- 435

  Fly  1200 RWRSLCNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVT 1264
            .|         |||:..  :.|......:..||||.....:::..|.::....:...|...||..
  Rat   436 SW---------PFLEPV--DESYAPNYYQIIKIPMDISSMEKKLNGGLYCTKEEFVNDMKTMFRN 489

  Fly  1265 ---YNGNAYDMGNYVGGSAQAASNNPNP--HHVMP--------NVNDNLVIKATMQR-------- 1308
               |||   |...|.     ..|.|...  |..|.        :.::...|:...:|
  Rat   490 CRKYNG---DSSEYT-----KMSENLERCFHRAMTKHFPGEDGDTDEEFWIREDEKREKRRSRAG 546

  Fly  1309 --------TQVHTTAASTLKMTTVDNRLELNTAVYGTEPIGDKKLRNLLQKNSTEPMLMGANSDL 1365
                    |:...|..|:.|...::|              |.|.|         .|....|:|
  Rat   547 RSSGSHVWTRSRDTEGSSRKQPPMEN--------------GGKSL---------PPARRAASS-- 586

  Fly  1366 FLGNDVMRLGMM------------------------QNTPITQNNPMLS-ISGKSQPSE-----G 1400
              |:|.....:.                        |..|:.|..|..| ..|..|.|:     |
  Rat   587 --GDDQSSSSIQLPPEVGTSNGRGFFHPLHYSRVPSQAPPLNQMRPAASGTFGSLQGSDPTNLHG 649

  Fly  1401 RSLEQDVKLGEPQEATSSAVELENVGFSDLLGGLGEGDDDDLLKSLT--SEMGDDFNILEYADPE 1463
            .|...:|..|||.:....|::.. ||.|:..|......::.:...||  |.||...       |.
  Rat   650 SSRIPEVPPGEPLQHPPFAIQAP-VGISNHRGSRLSAPEEKMCGGLTHLSNMGSHV-------PS 706

  Fly  1464 LDVNVLNSLDFDDN 1477
            |.:..:|....|.|
  Rat   707 LQLGQMNCNSQDGN 720

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	25/148 (17%)
		HMG	1173..1231	CDD:197700	7/57 (12%)
Cecr2	XP_008761473.1	WHIM3	244..284	CDD:292248	3/39 (8%)
Cecr2	XP_008761473.1	Bromo_gcn5_like	418..518	CDD:99941	26/138 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900