Protein Alignment Lpt and Set1

DIOPT Version :9

• Sequence 1: NP_611847.2
• Gene: Lpt / 37795
• FlyBaseID: FBgn0263667
• Length: 1482
• Species: Drosophila melanogaster
• Sequence 2: NP_001015221.1
• Gene: Set1 / 3354971
• FlyBaseID: FBgn0040022
• Length: 1641
• Species: Drosophila melanogaster
• Alignment Length: 1116
• Identity: 201/1116 - (18%)
• Similarity: 350/1116 - (31%)
• Gaps: 377/1116 - (33%)

  Fly   367 DEEADLTAYHKKKEQNPDYDYVC-----PNCKSN---------SSGPGSSQQTID-----SIVLS 412
            |||.     |.|....|.: |.|     |...||         .:.|.|...|:|     :::..
  Fly   472 DEEE-----HDKNSIVPTH-YGCMAKLQPPVPSNVNFATKLQSVTQPNSDPGTVDLDTRIALIFK 530

  Fly   413 A-----------MDSSSEQLSLKEIELDPLEGKPTM--DPSSDELHKLPTGKKKVCLTSVRGRSG 464
            .           ||||..:..         :|||.:  |.:||..:.  ..||:.|      ...
  Fly   531 GKTFGNAPPFLQMDSSDSETD---------QGKPEVFSDVNSDSNNS--ENKKRSC------EKN 578

  Fly   465 KFVLHRMGVMSQINKKRSTRGKGRQLALPTISSDRC-LSRSMETDLTSDK-KLLLCSARDKFIQA 527
            ..|||:....|.|:......||          .|:. ||...|.::..|. .|...|:::..||.
  Fly   579 NKVLHQPNEASDISSDEELIGK----------KDKSKLSLICEKEVNDDNMSLSSLSSQEDPIQT 633

  Fly   528 QDICVMCGSLGIESDSVMITCAQCGQCYHP----------YCAGVKPSRGILQKGWRCLDCTVCE 582
            ::        |.|..|:|.:........:|          |.:|: ||
  Fly   634 KE--------GAEYKSIMSSYMYSHSNQNPFYYHASGYGHYLSGI-PS----------------- 672

  Fly   583 GCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTE--KSEFGDSN 645
                 ...:||       .|...|..:..|:.|.:.|:. ||        ..|.:  |....|.|
  Fly   673 -----ESASRL-------FSNGAYVHSEYLKAVASFNFD-SF--------SKPYDYNKGALSDQN 716

  Fly   646 MLECPSCTSQSSCPVCKVSYSNGEM--------------IIQCEHCELWAHFHCDSVNAQLTIDH 696
                 ....|....|  :.|...|:              |...:|.|.|...|.....::...:.
  Fly   717 -----DGIRQKVKQV--IGYIVEELKQILKRDVNKRMIEITAFKHFETWWDEHTSKARSKPLFEK 774

  Fly   697 YDNNVYKCFKCRCSTRSTNSLAD-----------AKFGNEDSLAITPQGSK--PFVHITASSGP- 747
            .|:.|.....|...|.......|           |.|.:..|:.:.....|  .|..|.....|
  Fly   775 ADSTVNTPLNCIKDTSYNEKNPDINLLINAHREVADFQSYSSIGLRAAMPKLPSFRRIRKHPSPI 839

  Fly   748 ----SF------DSKSGAERNHPTLSGDMPESAPEALHWIDG-VCLSESGLGMIKSLSTEIKRKR 801
                :|      |.:...:|:.........|.:..|...|.| |.:.||.   .||.::.:..||
  Fly   840 PTKRNFLERDLSDQEEMVQRSDSDKEDSNVEISDTARSKIKGPVPIQESD---SKSHTSGLNSKR 901

  Fly   802 K-----MRQALGNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNILRKKRQR 861
            |     ...:..:....:.|..|.:.:||.:.      :|...|.|:               .||
  Fly   902 KGSASSFFSSSSSSTSSEAEYEAIDCVEKART------SEEDSPRGY---------------GQR 945

  Fly   862 NLQKLGIGGFSVRNRGLKKDSEETTAVDQINSLMTMD--------------KKKKIIRKKQKNKL 912
            ||                  ::.||.:...|.:.|||              ||:.:.::.:||
  Fly   946 NL------------------NQRTTTIRNRNLVGTMDVINVRNLCSGSNEFKKENVTKRTKKN-- 990

  Fly   913 IEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKT 977
                                   :.:|||..::     :..|       ||.::         |.
  Fly   991 -----------------------IYSDTDEDND-----RTLF-------PALKE---------KN 1011

  Fly   978 VKKVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFAN---RHPLDALASPN 1039
            :..:.::|:..:|...|     |: ::||..|.      :..:|.||...|   |..|..:..|.
  Fly  1012 ISTILSDLEEISKDSCI-----GL-DENGIEPT------ILRKIPNTPKLNEECRRSLTPVPPPG 1064

  Fly  1040 VPELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLG------------ 1092
            ..|.::...|      :..:||..|...:..||  ...:..||::..|..|:.
  Fly  1065 YNEEEIKKKV------DCKQKPSFEYDRIYSDS--EEEKEYQERRKRNTEYMAQMEREFLEEQEK 1121

  Fly  1093 ------GNTLVNPAQQLQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGT 1151
                  ...|.:| ..:.....:|:|.|.:..:|.:|    ||....|...||...:...::  .
  Fly  1122 RIEKSLDKNLQSP-NNIVKNNNSPRNKNDETRKTAIS----QTRSCFESASKVDTTLVNIIS--V 1179

  Fly  1152 QKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWND-------RCKQI-LKRWRSL---- 1204
            :....:....|:..::......:|.|::....:...|::::       :..|: |:...||
  Fly  1180 ENDINEFGPHEEGDVLTNGCNKMYTNSKGKTKRTQSPVYSEGGSSQASQASQVALEHCYSLPPHS 1244

  Fly  1205 ----------CNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQEEMGRVWKQ--PPKLKED 1257
                      .||.| ..|::..:|.:.:.|.....    |.:|:|.....:..|:  .|::...
  Fly  1245 VSLGDYPSGKVNETK-NILKREAENIAIVSQMTRTG----PGRPRKDPICIQKKKRDLAPRMSNV 1304

  Fly  1258 QPNMFVTYNGNAY-DMGNYVGGSAQAASNNPNPHHVMPNV------NDNLVIKATMQRTQVHTTA 1315
            :..|  |.||:.: |:.            :.|.|.|..::      |:.:||..|.....:....
  Fly  1305 KSKM--TPNGDEWPDLA------------HKNVHFVPCDMYKTRDQNEEMVILYTFLTKGIDAED 1355

  Fly  1316 ASTLKMTTVDN 1326
            .:.:||:.:|:
  Fly  1356 INFIKMSYLDH 1366

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600	9/29 (31%)
		PHD4_KMT2C_like	530..578	CDD:276987	9/57 (16%)
		PHD5_KMT2C_like	580..625	CDD:276988	8/44 (18%)
		PHD6_KMT2C_like	657..707	CDD:276989	10/63 (16%)
		NHP6B	1101..>1237	CDD:227935	25/157 (16%)
		HMG	1173..1231	CDD:197700	13/79 (16%)
Set1	NP_001015221.1	RRM_Set1	99..191	CDD:240750
		DUF1777	255..>380	CDD:285811
		PRP38_assoc	<318..388	CDD:289628
		N-SET	1341..1492	CDD:288597	6/26 (23%)
		SET	<1463..1641	CDD:225491
		SET	1504..1625	CDD:214614

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030