DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Ep300

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_006521152.1	Gene:	Ep300 / 328572	MGIID:	1276116	Length:	2422	Species:	Mus musculus

Alignment Length:	1685	Identity:	288/1685 - (17%)
Similarity:	505/1685 - (29%)	Gaps:	606/1685 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VSMEEKAVADDLPYFPEKFPGKVCCLCNLGEKSALGQGEILQLKAPAPAEIKDKYPTDRLREDGS 71
            |.||.|...|.    ||....:       .|.:...:||.::::   |.|::::.|  .|:.||.
Mouse   975 VKMESKMEVDK----PEPADAQ-------PEDTKEAKGEDVKVE---PTEMEERGP--ELKTDGK 1023

  Fly    72 RLLYGPKQAASSSG------------------------DCHYELDK-------------IGQPD- 98
            .....|..:|:.|.                        :..|..|.             :|.||
Mouse  1024 EEEEQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDY 1088

  Fly    99 ---VVHPAEF------LDEG-----FVYVHRMCIM------WSLRKSQISDADGAYFATHFAEFL 143
               |..|.:.      ||.|     :.|:..:.:|      ::.:.|::..     :.:..:|..
Mouse  1089 FDIVKSPMDLSTIKRKLDTGQYQEPWQYIDDIWLMFNNAWLYNRKTSRVYK-----YCSKLSEVF 1148

  Fly   144 EQKCN--------FCGR---YGASINCKMNCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPV 197
            ||:.:        .|||   :.....|           |.....|.:..:: |.:..::.|....
Mouse  1149 EQEIDPVMQSLGYCCGRKLEFSPQTLC-----------CYGKQLCTIPRDA-TYYSYQNSSPQYG 1201

  Fly   198 ICSDNNVECLSC--------SSLGD-------------LSK----------LIMCSTCGDHFHST 231
            :.:|....|..|        .||||             .||          .:.|:.||...|..
Mouse  1202 LLADRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQI 1266

  Fly   232 CIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKC--------------------------E 270
            |: |.:.....||:.|..|.| :..|.:..|.....:.                          |
Mouse  1267 CV-LHHEIIWPSGFVCDGCLK-KTARTRKENKLSAKRLPSTRLGTFLENRVNDFLRRQNHPESGE 1329

  Fly   271 QCQKTYHASC----LRPVISA------------------------------------IPKYGWKC 295
            ...:..|||.    ::|.:.|                                    :.:||..|
Mouse  1330 VTVRVVHASDKTVEVKPGMKARFVDSGEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDC 1394

  Fly   296 ---NRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPICQKAYRAASHKEMV---- 353
               |:.||                   :.:..||.:      |..|.|.:.  |..|:.::
Mouse  1395 PPPNQRRV-------------------YISYLDSVH------FFRPKCLRT--AVYHEILIGYLE 1432

  Fly   354 ---KCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCKSNSSGPGSSQQTIDSIVLSAMD 415
               |..:....:.:....|.|            ||.:.|.........|...|:....::..|:.
Mouse  1433 YVKKLGYTTGHIWACPPSEGD------------DYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVS 1485

  Fly   416 -------------------SSSEQL--------------SLKEIELDPLEGKPTMDPSSDELHKL 447
                               :|:::|              |:||:|.:..|.|...:.|::.
Mouse  1486 ERIVHDYKDILKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEERKREENTSNES---- 1546

  Fly   448 PTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKGRQLALPTISSD--RCLSRSME---- 506
                     |.|.....|....:....:..||...:||..::..:|.:|:|  :.|..:||
Mouse  1547 ---------TDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKE 1602

  Fly   507 ---------------------------TDLTSDKKLLLCSARDKFIQAQDI-----CVMCGSLGI 539
                                       .||...:...|..||||.::...:     ..||..:.:
Mouse  1603 VFFVIRLIACPAPNSLPPIVDPDPLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVEL 1667

  Fly   540 ESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCEG------C-GKKNDEAR----- 592
            .:.|.......|.:|.|.           ::..|.   |||||.      | ..||.:.:
Mouse  1668 HTQSQDRFVYTCNECKHH-----------VETRWH---CTVCEDYDLCITCYNTKNHDHKMEKLG 1718

  Fly   593 LLLCDECD---------------ISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFG 642
            |.|.||.:               :|.. .|:...:......|..||..: |||..|
Mouse  1719 LGLDDESNNQQAAATQSPGDSRRLSIQ-RCIQSLVHACQCRNANCSLPS-CQKMKR--------- 1772

  Fly   643 DSNMLECPSCTSQSS--CPVCKVSYSNGEMIIQC----EHCE---LWAHFHCDSVNAQLTIDHYD 698
              .:.....|..:::  ||:||      ::|..|    :||:   ....| |.::..:|......
Mouse  1773 --VVQHTKGCKRKTNGGCPICK------QLIALCCYHAKHCQENKCPVPF-CLNIKQKLRQQQLQ 1828

  Fly   699 NNVYKCFKCRCSTRS----------------TNSLADAKFGNEDSLAITPQ-------------G 734
            :.:.:....|....|                |.:......|.:.:...|||             .
Mouse  1829 HRLQQAQMLRRRMASMQRTGVAGQQQGLPSPTPATPTTPTGQQPATPQTPQPQPTSQPQPTPPNN 1893

  Fly   735 SKPFVHITASSGPSFDSKSGAERNHPT--------LSGDMPESAPEALHWIDGVCLSESGLGMIK 791
            ..|::..|.::||....|:..:...||        |.|. |.:|.|....|.....::..:..::
Mouse  1894 MTPYLPRTQTTGPVSQGKAPGQVTPPTPPQTAQAPLPGP-PPAAVEMAMQIQRAAETQRQMAHVQ 1957

  Fly   792 SLSTEIKRKRKMRQ----------ALGNGKDGQLEAAAEEALEKYKDGMVWDG------TENAIP 840
            .....|:.:.....          .:..|..|.|:.....|..:.:......|      .::.:|
Mouse  1958 IFQRPIQHQMPQMSPMAPMGMNPPPMARGPGGHLDPGIGPAGMQQQPPWAQGGMPQPQQMQSGMP 2022

  Fly   841 EGFTISINDEGVNILRKKRQRNLQKLGIGGFSVRNRGLKKDSEETTAVDQINSLMTMDKKKKIIR 905
            ....:|:...| ..|....|..|.::|:.       .||..:....|:.  |.|.|:......::
Mouse  2023 RPAMMSVAQHG-QPLNMAPQPGLGQVGVS-------PLKPGTVSQQALQ--NLLRTLRSPSSPLQ 2077

  Fly   906 KKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAV 970
            ::|...::.|.|                :|:.|               |.:......||.:...:
Mouse  2078 QQQVLSILHANP----------------QLLAA---------------FIKQRAAKYANPNPQPL 2111

  Fly   971 NKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDAL 1035
            ...|..|..:...:..|         || |.|..:....:.|: :||||.:.......:.|...|
Mouse  2112 PGQPGMTQGQPGLQPPT---------MP-GQQGVHSNPALQNM-NPLQAGVQRAGLPQQQPQQQL 2165

  Fly  1036 ------ASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGN 1094
                  .||...:::|.:  :|:||      ..|:         ::..|:.|:|        |..
Mouse  2166 QPPMGAMSPQAQQMNMNH--NTMPS------QFRD---------ILRRQMMQQQ--------GAG 2205

  Fly  1095 TLVNPAQQLQFRQ-----QAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKT 1154
            ..:.|....||:|     ..||...:|.||..|.|:     ::....|....|......||....
Mouse  2206 PGIGPGMANQFQQPQGIGYPPQQQQQQRMQHHMQQM-----QQGNMGQMGQLPQALGAEAGASLQ 2265

  Fly  1155 AEKMR-KDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKD 1218
            |.:.| ..:.:|..|           .||             .:..:...|.|:.::|.||..:.
Mouse  2266 AYQQRLLQQQMGSPA-----------QPN-------------PMSPQQHMLPNQAQSPHLQGQQI 2306

  Fly  1219 NRSALRQRREQNKIPMPPKPQKQ----EEMGRVWKQP------PKLKEDQPNMFVTYNGNAYDMG 1273
            ..|...|.|....:| .|:||.|    ....|:..||      |:.....|.:.
Mouse  2307 PNSLSNQVRSPQPVP-SPRPQSQPPHSSPSPRMQPQPSPHHVSPQTSSPHPGLV----------- 2359

  Fly  1274 NYVGGSAQAASNNPNPHHVMPNVNDNL-VIKATMQRTQVHTTAASTLKMTTVDNRLELNT 1332
                 :||||:.....|...|:.|..| .:.:......:|..:|:.|.::: || .:||:
Mouse  2360 -----AAQAANPMEQGHFASPDQNSMLSQLASNPGMANLHGASATDLGLSS-DN-ADLNS 2412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135	14/103 (14%)
		PHD1_KMT2C_like	205..250	CDD:276984	17/75 (23%)
		PHD2_KMT2C_like	252..298	CDD:276985	13/114 (11%)
		PHD_SF	337..392	CDD:304600	10/61 (16%)
		PHD4_KMT2C_like	530..578	CDD:276987	7/52 (13%)
		PHD5_KMT2C_like	580..625	CDD:276988	15/71 (21%)
		PHD6_KMT2C_like	657..707	CDD:276989	11/58 (19%)
		NHP6B	1101..>1237	CDD:227935	29/141 (21%)
		HMG	1173..1231	CDD:197700	10/57 (18%)
Ep300	XP_006521152.1	KIX	567..647	CDD:366953
		PABP-1234	<714..848	CDD:130689
		Merozoite_SPAM	959..>1048	CDD:284533	19/88 (22%)
		Bromo_cbp_like	1050..1157	CDD:99927	16/111 (14%)
		RING_CBP-p300	1169..1251	CDD:276805	14/93 (15%)
		PHD_p300	1252..1286	CDD:277116	10/34 (29%)
		HAT_KAT11	1315..>1526	CDD:369758	30/249 (12%)
		ZZ_CBP	1677..1717	CDD:239077	12/53 (23%)
		ZnF_TAZ	1738..1816	CDD:214717	19/97 (20%)
		Med15	1968..>2344	CDD:312941	88/482 (18%)
		Creb_binding	2016..2109	CDD:370251	21/133 (16%)
		Med15	88..>328	CDD:312941
		zf-TAZ	348..415	CDD:366931
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900