back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Pbrm1

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_006252748.1	Gene:	Pbrm1 / 306254	RGDID:	1565549	Length:	1726	Species:	Rattus norvegicus

Alignment Length:	1136	Identity:	213/1136 - (18%)
Similarity:	337/1136 - (29%)	Gaps:	445/1136 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 KKKEQNP---DYDYVCPNCK-SNSSG--PGSS------QQTIDSI---VLSAMDSSSEQLSLKEI 426
            |:||..|   |.|...|..| |..||  |..|      ||.::.:   |.:..|....:||...:
  Rat   658 KRKELGPLPDDDDMASPKLKLSRKSGVSPKKSKYMTPMQQKLNEVYEAVKNYTDKRGRRLSAIFL 722

  Fly   427 ELDPLEGKPTMDPSSDELHKLP----TGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKG 487
            .|          ||..|   ||    |.||.:.:..:|.       |.|.     ||.:......
  Rat   723 RL----------PSRSE---LPDYYLTIKKPMDMEKIRS-------HMMA-----NKYQDIDSMV 762

  Fly   488 RQLALPTISSDRCLSRSMETDLTSD----KKLLLCSARDKFIQAQDICVMCGSLGIESD------ 542
            ....:  :.::.|.....|:.:..|    .|:||.:.||                :|.|
  Rat   763 EDFVM--MFNNACTYNEPESLIYKDALVLHKVLLETRRD----------------LEGDEDSHVP 809

  Fly   543 ---------------SVMITCAQCGQCYHPYCAGVK------PSR-----GILQKGWRCLDCTVC 581
                           |||......|:||....|.:.      |||     .|::|.
  Rat   810 NVTLLIQELIHNLFVSVMSHQDDEGRCYSDSLAEIPAVDPNFPSRPPLTFDIIRKN--------- 865

  Fly   582 EGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGR-NPTEKSEFGDSN 645
               .:.|...||.|..|     |::                   .:.::..| |.|:...:.|:
  Rat   866 ---VESNRYRRLDLFQE-----HMF-------------------EVLERARRMNRTDSEIYEDA- 902

  Fly   646 MLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKCRCS 710
             :|......:....:||    |||:::              |.....|..|..|:|.|..|
  Rat   903 -VELQQFFIRIRDELCK----NGEILL--------------SPALSYTTKHLHNDVEKEKK---- 944

  Fly   711 TRSTNSLADAKF----------GNEDSLAITPQGSKPFVHITASSGPSFDSK----------SGA 755
            .:....:.:.|.          .:|||...|....   :|.|.|...||.:.          ..|
  Rat   945 EKLPKEIEEDKLKREEEKREAEKSEDSSGTTGLSG---LHRTYSQDCSFKNSMYHVGDYVYVEPA 1006

  Fly   756 ERN-HP---TLSGDMPESAPEALHWIDGVCLSESG----LGMIKSLSTEIKR-----KRKMRQAL 807
            |.| .|   .:.....:||.|  .|:.|.......    |...|.|..|:.:     |..:.:.|
  Rat  1007 EANLQPHIVCIERLWEDSAGE--KWLYGCWFYRPNETFHLATRKFLEKEVFKSDYYNKVPVSKIL 1069

  Fly   808 GNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNILRKKRQRNLQKLGIGGFS 872
            |       :.......|.:|          ..||.|    .||.|.:...:            :|
  Rat  1070 G-------KCVVMFVKEYFK----------LCPETF----RDEDVFVCESR------------YS 1101

  Fly   873 VRNRGLKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVM 937
            .:.:..||....|..:..:. .:..|....::|...                           |.
  Rat  1102 AKTKSFKKIKLWTMPISSVR-FVPRDVPLPVVRVAS---------------------------VF 1138

  Fly   938 ADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQ 1002
            |:.|..|             |.||..|.|......|         ..|:.|.:.|       .::
  Rat  1139 ANADKGD-------------EEKSTDNSDDNRAEDS---------FNLEKEKEDV-------PVE 1174

  Fly  1003 NKNGTTPVSNVFDPLQ-----AEISNTVFANRHPLDALASPNV---------------------- 1040
            ..|| .|..:.|:.|:     .::.:.||...|   .|..|.|
  Rat  1175 MSNG-EPGCHYFEQLRYNDMWLKVGDCVFIKSH---GLVRPRVGRIEKVWVRDGAAYFYGPIFIH 1235

  Fly  1041 --------------PELDMANSVSTVPSAEVIEKPMRESPAVLVDSF-----MVPNQLP------ 1080
                          .|:.::|...|.|.:.::.|     .|||  ||     ..|.::|
  Rat  1236 PEETEHEPTKMFYKKEVFLSNLEETCPMSCILGK-----CAVL--SFKDFLSCRPTEIPENDILL 1293

  Fly  1081 ----------QEQKFHNQLYLGGNTLVNPAQQLQFR-----QQAPQNANKQNMQTIMSQVVL--- 1127
                      |.:||........:..|...:...||     |:.|....::.:|.:.::...
  Rat  1294 CESRYNESDKQMKKFKGLKRFSLSAKVVDDEIYYFRKPIIPQKEPSPLLEKKIQLLEAKFAELEG 1358

  Fly  1128 ---QTEKRPEEEQKVVEP----------------VTETLNAGTQKTAEKMRKDEDLGLMATISAV 1173
               .||:..||:.:|:||                :..|....|.|:|:...|.|.......:|..
  Rat  1359 GDDDTEEMGEEDSEVIEPPSLPQLQTPLANELDLMPYTPPQSTPKSAKGSAKKESSKRKINMSGY 1423

  Fly  1174 LYANTE--------HPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALRQRRE-- 1228
            :..::|        ||:..     :.:..:.:...||:|...|||.:.::|.  ::|.:|.||
  Rat  1424 ILFSSEMRAVIKAQHPDYS-----FGELSRLVGTEWRNLETAKKAEYEERAA--KAAEQQERERA 1481

  Fly  1229 -QNKIPM-----------------PPKP------QKQEEMGRVWKQPPKLKEDQPNMFVTYNGNA 1269
             |.:.|.                 ||.|      |.....|.:...||.|    |.:....:| .
  Rat  1482 AQQQQPSASPRAGTPVGALMGVVPPPTPMGMLNQQLTPVAGMMGGYPPGL----PPLQGPVDG-L 1541

  Fly  1270 YDMGN----YVGGSAQAASNNPNPHHVMPNV 1296
            ..||:    :.||        |.|||:.|.|
  Rat  1542 VSMGSMQPLHPGG--------PPPHHLPPGV 1564

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.