DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpt and Kat2a

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_006247379.1	Gene:	Kat2a / 303539	RGDID:	1307242	Length:	833	Species:	Rattus norvegicus

Alignment Length:	448	Identity:	84/448 - (18%)
Similarity:	153/448 - (34%)	Gaps:	132/448 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   605 IYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFGDSNMLECP---SCTSQSSCPVCKVSYS 666
            ||..|.|:       |:..|.       ..|:|.::     ::..|   |.|...|.|:...|..
  Rat   362 IYGANSPI-------WESGFT-------MPPSEGTQ-----LVPRPATVSATVVPSTPIFSPSMG 407

  Fly   667 NGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKCRCSTRSTNSLADAK---------- 721
            .|.                   |:.|::|..........:.| ......:|.|||
  Rat   408 GGS-------------------NSSLSLDSTGTEPMPAGEKR-KLPENLTLEDAKRLRVMGDIPM 452

  Fly   722 -FGNEDSLAIT-------PQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMPESAPEALHWID 778
             ..||..|.||       |:.|....:.........:.:.|....|...:...|::....|.|:
  Rat   453 ELVNEVMLTITDPAAMLGPETSLLSANAARDETARLEERRGIIEFHVIGNSLTPKANRRVLLWL- 516

  Fly   779 GVCLSESGLGMIKSLSTEIKR--KRKMRQALGNGKDGQLEAAAEEALEKYKDGMVWDG-TENAIP 840
                    :|:....|.::.|  |..:.:.:.:.|        .:.|...|||.|..| .....|
  Rat   517 --------VGLQNVFSHQLPRMPKEYIARLVFDPK--------HKTLALIKDGRVIGGICFRMFP 565

  Fly   841 -EGFT------ISINDE----GVNILRKKRQRNLQ-----------KLGIG-----GFS------ 872
             :|||      ::.|::    |.:::...::.:::           :..||     |||
  Rat   566 TQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKHSILYFLTYADEYAIGYFKKQGFSKDIKVP 630

  Fly   873 -VRNRGLKKDSEETTAVD-QINSLMTMDKKKKIIRKKQK--NKLIEAYPVYLQEAFFGKPLL-EG 932
             .|..|..||.|..|.:: ::|..:...:...||:|:::  .||||.....:::.:.|.... ||
  Rat   631 KSRYLGYIKDYEGATLMECELNPRIPYTELSHIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKEG 695

  Fly   933 GELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAK---TVKKVKAELKT 987
            ...:..::           |...|..|..|..::.....|.|.:   |:|.:.|::|:
  Rat   696 VRQIPVES-----------VPGIRETGWKPLGKEKGKELKDPDQLYTTLKNLLAQIKS 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988	5/19 (26%)
		PHD6_KMT2C_like	657..707	CDD:276989	7/49 (14%)
		NHP6B	1101..>1237	CDD:227935
		HMG	1173..1231	CDD:197700
Kat2a	XP_006247379.1	PCAF_N	81..330	CDD:283997
		COG5076	488..828	CDD:227408	54/283 (19%)
		Acetyltransf_1	551..623	CDD:278980	13/71 (18%)
		Bromo_gcn5_like	728..827	CDD:99941	4/15 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900