DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lpt and SETD2

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:XP_011531934.1 Gene:SETD2 / 29072 HGNCID:18420 Length:2572 Species:Homo sapiens


Alignment Length:1274 Identity:244/1274 - (19%)
Similarity:408/1274 - (32%) Gaps:424/1274 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   257 RQQDSNDTKYVKCEQCQK-TYHASCLRPVISAIPKYGWKCNRCR-----------VCTDCGSRTP 309
            |.:...|.||....:.:: |.:.|                :|||           ..::.||||.
Human   376 RSKTDRDDKYFSYSKLERDTRYVS----------------SRCRSERERRRSRSHSRSERGSRTN 424

  Fly   310 GGGSSSRWHSHYTICD------SCYQQRNKGFSCPIC-QKAYRAASHKEMVKCSWCNK-FVHSTC 366
            ...|.|. .|||...|      |.|::|.: :|.|.. .:|..::..:|..|.::..: ..||:.
Human   425 LSYSRSE-RSHYYDSDRRYHRSSPYRERTR-YSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSS 487

  Fly   367 DEEADLTAYHKKKEQNPDYDYVCPNCKSNSS-------GPGSSQQTIDSIVLSAMDSSSEQLSLK 424
            ..:...::|.|.     |.|     ||:.:|       |..||:...:|      ..:||..::|
Human   488 YRDLRTSSYSKS-----DRD-----CKTETSYLEMERRGKYSSKLERES------KRTSENEAIK 536

  Fly   425 EIELDPLE-----------------------GKPTMDPSSDELHKLPTGKKKVCLTSVR---GRS 463
            .....|.|                       .||.  |.||:.      |...|.|.:.   .:|
Human   537 RCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPI--PKSDKF------KNSFCCTELNEEIKQS 593

  Fly   464 GKFVLH----RMGVMSQINKKRSTRGKGRQLALPTISSDRCLSRSMETD------LTSDK----K 514
            ..|.|.    :...:..|||.......|.......::....|.:..|..      :|.|.    |
Human   594 HSFSLQTPCSKGSELRMINKNPEREKAGSPAPSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIK 658

  Fly   515 LLLCSARDKFIQAQDICV----MCGSLGIES----------DSVMITC--AQCGQCYHPYCAGVK 563
            .|...::.|..|.:..|.    :.||.|.||          |:|::|.  :..|....|......
Human   659 ELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSELSPLVKACM 723

  Fly   564 PSRGILQKGWRCLDCTVCEGC--GKKND-------------EARLLLCDECDISYHIYCVNPPLE 613
            .|....|...||.:..:.:.|  .||::             :.:|:......:.|....|..|::
Human   724 LSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVD 788

  Fly   614 T-VPTGNWKCS--FCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCE 675
            | |.....|.|  :|||              .|||...|.|........|.|:| ||..|.:..|
Human   789 TRVSCCKTKDSDIYCTL--------------NDSNPSLCNSEAENIEPSVMKIS-SNSFMNVHLE 838

  Fly   676 HCELWAHFHCDSVNAQLTIDHYDNNVYKCFKCRCSTRSTNSLADAKF----------GNEDSLAI 730
            ...:    .|||.|  ||    |::.:.|.:.:.|..||:|.:...|          |...||..
Human   839 SKPV----ICDSRN--LT----DHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQS 893

  Fly   731 TPQGSK----PFVHITASSGPSFDSKSGAERNHPTLSGDMPESAPEALHWIDGVCLSESGLGMIK 791
            .|.|.|    ..:....::.|..|:...::::...|.....|:..|.     |..|.:||.|.  
Human   894 LPPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEV-----GSDLPDSGKGF-- 951

  Fly   792 SLSTEIKRKRKMRQALGNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNILR 856
             .|.|.:|        .||..|:....|:|                            ||.:||.
Human   952 -ASRENRR--------NNGLSGKCLQEAQE----------------------------EGNSILP 979

  Fly   857 KKRQR---NLQKLGIGGFSVRNRGLKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNKLIEAYPV 918
            ::|.|   :|.:.|.||    :.....|||...:...:|  :||:....:....:.:....|..:
Human   980 ERRGRPEISLDERGEGG----HVHTSDDSEVVFSSCDLN--LTMEDSDGVTYALKCDSSGHAPEI 1038

  Fly   919 Y--LQEAFFGKPLLEGGELVMADTDSSD------EIDASMKVYFTRPEGKSPANQDTLAVNKSPA 975
            .  :.|.:.|.......|....||||.|      .:.:.:.|    |:..:...::|...:...:
Human  1039 VSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRLQSVVVV----PKNSTLPMEETSPCSSRSS 1099

  Fly   976 KTVKKVK---AELKTENKTVFIQQMPMGIQNK-----------NGT--TPVSNVFDPLQAEISNT 1024
            ::.:...   .:.:.|::....::....|.:|           .||  .|..:.....:.:|.|.
Human  1100 QSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNR 1164

  Fly  1025 VFANRHP----LDALASPNVPE--LDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQ 1083
            :....||    :|:.:..:|..  |...||..|| .|::..:...|.|....|...|||:..|:.
Human  1165 LPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETV-KAKIPSRQQEELPIYSSDFEDVPNKSWQQT 1228

  Fly  1084 KFHNQ--LYLGGNTL-------------VNPAQQLQ-----FRQQAP------------------ 1110
            .|.|:  ..||...|             ::.:::|:     |.|:.|                  
Human  1229 TFQNRPDSRLGKTELSFSSSCEIPHVDGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHK 1293

  Fly  1111 --QNANKQN-------------------------MQTIMSQVV-LQTEKRPEEE----------- 1136
              |||.:..                         ......||. ..|:.|.|||           
Human  1294 YQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDREEEENWDQQDGSHFS 1358

  Fly  1137 ----------QK----VVEP------VTETLNAGTQKTAEKMRKDEDLGLMATISAVLYANTEHP 1181
                      ||    |..|      :.:||....:|...|                   |.|..
Human  1359 DQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSK-------------------NLEKN 1404

  Fly  1182 NLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALRQRR------EQNKIPMPP---- 1236
            ::|:..|:                 :|:...::...::...|:.|:      ||.:..:||    
Human  1405 DIKDRGPL-----------------KKRRQEIESDSESDGELQDRKKVRVEVEQGETSVPPGSAL 1452

  Fly  1237 -----------KPQKQEEMGRVWKQPPKLKEDQPNMFVT 1264
                       .||:.:|..:..|.|......:.|:::|
Human  1453 VGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLT 1491

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135
PHD1_KMT2C_like 205..250 CDD:276984
PHD2_KMT2C_like 252..298 CDD:276985 6/41 (15%)
PHD_SF 337..392 CDD:304600 10/56 (18%)
PHD4_KMT2C_like 530..578 CDD:276987 15/63 (24%)
PHD5_KMT2C_like 580..625 CDD:276988 11/62 (18%)
PHD6_KMT2C_like 657..707 CDD:276989 15/49 (31%)
NHP6B 1101..>1237 CDD:227935 33/238 (14%)
HMG 1173..1231 CDD:197700 9/63 (14%)
SETD2XP_011531934.1 AWS 1503..1557 CDD:197795
SET 1558..1681 CDD:214614
PostSET 1682..1698 CDD:214703
Asp-B-Hydro_N <1948..2131 CDD:191249
WW 2399..2428 CDD:278809
SRI 2477..2556 CDD:285448
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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