DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Setd2

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_036010808.1	Gene:	Setd2 / 235626	MGIID:	1918177	Length:	2551	Species:	Mus musculus

Alignment Length:	1386	Identity:	257/1386 - (18%)
Similarity:	468/1386 - (33%)	Gaps:	457/1386 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 LSCSSLGDLSKLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKC-- 269
            ||.||..|:|::       |..||: ..|.||     ||:.::..:.....||.  |:.|..|
Mouse  1222 LSFSSSCDISRM-------DGLHSS-EELRNL-----GWDFSQQERPTTTYQQP--DSSYGTCGT 1271

  Fly   270 -EQCQKTYHASCLRPVISAIPKYG-----WKCNRCRVCTDCGSRTPGGGSSSRWHSHY-----TI 323
             :..|.|.|             ||     |:.|........| |.||.|.:      |     .:
Mouse  1272 HKYQQSTEH-------------YGGTHNYWQGNGYWDPRSAG-RPPGTGLA------YDRIQGQV 1316

  Fly   324 CDSCYQQRNKGFSCPICQKAY--RAASHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYD 386
            .||....|.:       ::.:  |:.||..    |..|||.            :|:|.
Mouse  1317 PDSLTDDREE-------EEHWDQRSGSHFS----SPSNKFF------------FHQKD------- 1351

  Fly   387 YVCPNCKSNSSGPGSSQQTI-DSIVLSAMDSSSEQLSLKEIEL--DPLEGKPTMDPSSDELHKLP 448
                  |.:...|..|..:| |::|::.....|:.....:|:.  .|.:.:..::..|:...:|
Mouse  1352 ------KGSVQAPEISSNSIKDALVMNERKDFSKNFEKNDIKERGPPKKRRQELESDSESDGEL- 1409

  Fly   449 TGKKKVCLTSVRGRSGKFVLHR--MGVMSQINKKRSTRGKGRQLA----LP----TISSDRCLSR 503
            ..:|||.:...:|.| ....|.  ||....::..|..: :.::.|    :|    .|..:..|:.
Mouse  1410 QARKKVRVEMEQGES-SVPQHSELMGPSCAMDDFRDPQ-RWKEFAKLGKMPCYFDLIEENVYLTE 1472

  Fly   504 SMETDLTSDKKLLLCS----ARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYH-PYCAGVK 563
            ..:.....|.|.:.|.    ::|:..|.:   |.||. ...:..:||.|:  .:|.: .||:..:
Mouse  1473 RKKNKSHRDIKRMQCECTPLSKDERAQGE---VACGE-DCLNRLLMIECS--SRCPNGDYCSNRR 1531

  Fly   564 PSRG-------IL--QKGWRC-------LDCTVCEGCGK----KNDEARLL-LCDECDISYHIYC 607
            ..|.       ||  :|||..       .:..|.|.||:    |..:||:. .....:|.|:...
Mouse  1532 FQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYFMA 1596

  Fly   608 V--NPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEM 670
            :  :..::....||           |.|......|         |:|.:|...       .||::
Mouse  1597 LKNDEIIDATQKGN-----------CSRFMNHSCE---------PNCETQKWT-------VNGQL 1634

  Fly   671 IIQCEHCELWAHFHCDSV--NAQLTIDH----YDNNVYKCF----KCRCSTRSTNSLADAKFGNE 725
            .:        ..|....|  .::||.|:    |.....|||    .||           ...|.|
Mouse  1635 RV--------GFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCR-----------GYLGGE 1680

  Fly   726 DSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMPESAPEALHWIDGVCLSESGLGM- 789
            :.::|...|.|              .|....|...::.|::     ||        |.|:|.|:
Mouse  1681 NRVSIRAAGGK--------------MKKERSRKKDSVDGEL-----EA--------LMENGEGLS 1718

  Fly   790 ----IKSLSTEIKRKRKMRQALGNGK---DGQLEAAAEEALEKYKDGMVW-------DGTENAIP 840
                :.|||..:.|...:.|.|...|   :...::..:..||::...::|       ||.|:
Mouse  1719 DKNQVLSLSRLMVRIETLEQKLTCLKLIQNTHSQSCLKSFLERHGLSLLWIWMAELGDGRES--- 1780

  Fly   841 EGFTISINDEGVNILRKKRQRNLQKLGIGGFSVRNRG-----LKKDSEETTAVDQI--------- 891
                   |.:    |:::..:.|:.|.|...::....     :::.|:..|||.|:
Mouse  1781 -------NQK----LQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPQLSEGDGYSSE 1834

  Fly   892 ------------------NSLMTMDKKKKIIRKKQK----NKLIEAYPVYLQ--EAFFGKPLLEG 932
                              ::.|..|..||:|.::.|    |.:..|......  |...||..|:.
Mouse  1835 NTSRAHTPLNTPDPSAKPSTEMDTDTPKKLIFRRLKIISENSMDSAVSDVTSELECKDGKEDLDQ 1899

  Fly   933 GELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQM 997
            .|.|..:.|  :|:.:...:.....|.| ..::.|:.|:|.|   ..:.:|:.:||.|
Mouse  1900 LETVTVEED--EELQSQQLLPQQLCESK-VESEATIEVSKLP---TSEPEADTETEPK------- 1951

  Fly   998 PMGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKP- 1061
                 :.|||                       .|:...:...|..|....||.|.|....|.|
Mouse  1952 -----DSNGT-----------------------KLEETIAEETPSQDEEEGVSDVESERSQEPPD 1988

  Fly  1062 ----MRESPAVLVDS-------FMVPNQLPQEQKFHNQLYLGGNTLVNPAQQ-LQFRQQ-APQNA 1113
                :.:....|:||       :.:|.:...|::         :|:....:. ..||.| ||:..
Mouse  1989 KTVDISDLATKLLDSWKDLKEVYRIPKKSQTEKE---------STVAERGRDAAAFRDQTAPKTP 2044

  Fly  1114 NKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLYANT 1178
            |:..            |:.|:::              :|...::.|:    |.::..|:.....|
Mouse  2045 NRSR------------ERDPDKQ--------------SQNKEKRKRR----GSLSPPSSAYERGT 2079

  Fly  1179 EHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQEE 1243
            :.|:  :.:.....:.|..:|....|..|::....::....|.|.:|:::...:.| ..|...:.
Mouse  2080 KRPD--DRYDTPTSKKKVRIKDRNKLSTEERRKLFEQEVAQREAQKQQQQMQNLGM-TSPLPFDS 2141

  Fly  1244 MGRVWKQPPKLKEDQPNMFVTYNGNAYDMGNYVGG---SAQAASNNPNPHHVM---PNVNDNLVI 1302
            :|                   ||.:.:....|..|   .|....:|||...|:   |:: |.:..
Mouse  2142 LG-------------------YNASHHPFAGYPPGYPMQAYVDPSNPNAGKVLLPTPSM-DPVCS 2186

  Fly  1303 KATMQRTQV---HTTAA-----STLKMTTVDNRLELNTAVYGTEPIGDKKLRNLLQKNSTEPML- 1358
            .|.....|.   |:|.:     |...:..|...:|::::.|..:.      .:::.::|..|::
Mouse  2187 PAPYDHAQPLVGHSTESLAAPPSVPVVPHVAASVEVSSSQYVAQN------ESVVHQDSNVPVMP 2245

  Fly  1359 -------MGANSDLFLGNDVMRLGMMQ------------------------NTPITQNNPMLSIS 1392
                   .|.|.:::..|. ..:.:.|                        .:|.:|..|.: :.
Mouse  2246 VQAPGPVQGQNYNVWESNQ-QSVSVQQQYSPAQSQTTIYYQGQTCSTVYSVTSPYSQTTPPI-VQ 2308

  Fly  1393 GKSQPSEGRSLEQDVKLGEPQ 1413
            ..:|||......|.:....||
Mouse  2309 SYAQPSLQYIQGQQIFTAHPQ 2329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984	14/42 (33%)
		PHD2_KMT2C_like	252..298	CDD:276985	12/53 (23%)
		PHD_SF	337..392	CDD:304600	9/56 (16%)
		PHD4_KMT2C_like	530..578	CDD:276987	15/64 (23%)
		PHD5_KMT2C_like	580..625	CDD:276988	11/51 (22%)
		PHD6_KMT2C_like	657..707	CDD:276989	11/59 (19%)
		NHP6B	1101..>1237	CDD:227935	22/137 (16%)
		HMG	1173..1231	CDD:197700	9/57 (16%)
Setd2	XP_036010808.1	AWS	1483..1537	CDD:197795	14/59 (24%)
		SET_SETD2	1537..1678	CDD:380949	35/186 (19%)
		WW	2378..2407	CDD:395320
		SRI	2454..2542	CDD:400510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030