DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and BRD4

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_001366220.1	Gene:	BRD4 / 23476	HGNCID:	13575	Length:	1362	Species:	Homo sapiens

Alignment Length:	1081	Identity:	180/1081 - (16%)
Similarity:	323/1081 - (29%)	Gaps:	365/1081 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 DLTAYHKKKEQN---------PDYDYVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSSEQLSLKEI 426
            |:....|:.|.|         .|::.:..||...:. ||      |.|||  |..:.|:|.|::|
Human   106 DMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK-PG------DDIVL--MAEALEKLFLQKI 161

  Fly   427 ELDPLEGKPTMDPSSDELHKLPTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKGRQ-- 489
                              ::|||.:.::.:...:|                      ||:||:
Human   162 ------------------NELPTEETEIMIVQAKG----------------------RGRGRKET 186

  Fly   490 -LALPTISSDRCLSRSMETDLTSDKKLLLCSARDKFIQA---------QDICVMCGSLGIESDSV 544
             .|.|.:|:....:::.....|...:     .....:||         .|:.|....:.:.....
Human   187 GTAKPGVSTVPNTTQASTPPQTQTPQ-----PNPPPVQATPHPFPAVTPDLIVQTPVMTVVPPQP 246

  Fly   545 MIT--------------CAQCGQCYHPYCAG----VKPSRGILQKGWRCLDCTV----------- 580
            :.|              ..|..|.:.|..|.    ||..:|:.:|.......|:
Human   247 LQTPPPVPPQPQPPPAPAPQPVQSHPPIIAATPQPVKTKKGVKRKADTTTPTTIDPIHEPPSLPP 311

  Fly   581 ---CEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFG 642
               ....|::.:.:|              .|.||.:.||...             ::|..:....
Human   312 EPKTTKLGQRRESSR--------------PVKPPKKDVPDSQ-------------QHPAPEKSSK 349

  Fly   643 DSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELW------------AHFHCD--------- 686
            .|..|:|  |:.     :.|      ||..:......|            .|.:||
Human   350 VSEQLKC--CSG-----ILK------EMFAKKHAAYAWPFYKPVDVEALGLHDYCDIIKHPMDMS 401

  Fly   687 SVNAQLTIDHY-DNNVY---------KCFKCR-------CSTRSTNSLADAKFG------NEDSL 728
            ::.::|....| |...:         .|:|..       ...|....:.:.:|.      .|..:
Human   402 TIKSKLEAREYRDAQEFGADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPEEPVV 466

  Fly   729 AITPQGSKPFVHITA---SSGPSFDSKSGAERNHPTLSGDMPESAPEALHWIDGVCLSESGLGMI 790
            |::.....|...:.|   ||..|.||.|.::.:......:..:...|....:..|  .|....:.
Human   467 AVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQEQLKAV--HEQLAALS 529

  Fly   791 KSLSTEIKRKRKMRQALGNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNIL 855
            :....:.|:|.|.::.....|..:.|...|....|.|:.          |...|...|....|:.
Human   530 QPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEP----------PPKKTKKNNSSNSNVS 584

  Fly   856 RK----------------------------KRQRNL-------QKLG--IGGFSVRNRGLKKDSE 883
            :|                            |||.:|       :|||  :.....|...||..:.
Human   585 KKEPAPMKSKPPPTYESEEEDKCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNP 649

  Fly   884 ETTAVD----------QINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMA 938
            :...:|          ::...:|...:||  ||.|..|:         :...|...::|  ...:
Human   650 DEIEIDFETLKPSTLRELERYVTSCLRKK--RKPQAEKV---------DVIAGSSKMKG--FSSS 701

  Fly   939 DTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKS-----PAKTVKKVKAELKTENKTVFIQQMP 998
            :::||.|..:|           ...:.:|....||     |.:..||.......:     :||.|
Human   702 ESESSSESSSS-----------DSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQ-----MQQAP 750

  Fly   999 MGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMR 1063
            ..:..:....|......|...:       .:.|......|::|:.......|:.|.....:.|:.
Human   751 APVPQQPPPPPQQPPPPPPPQQ-------QQQPPPPPPPPSMPQQAAPAMKSSPPPFIATQVPVL 808

  Fly  1064 E---------------SPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVN-PAQQLQFRQQAPQN 1112
            |               .|.:.:....:|..|||..:.....:|..:.:|: ||......||..:.
Human   809 EPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRP 873

  Fly  1113 AN-------KQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLMATI 1170
            :|       |......:|..:.||...|:..                              ||..
Human   874 SNRAAALPPKPARPPAVSPALTQTPLLPQPP------------------------------MAQP 908

  Fly  1171 SAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAK-----------DNRSALR 1224
            ..||..:.|.|    ..|:.:.:.:..|::.:.:  :...|.|...|           ....:::
Human   909 PQVLLEDEEPP----APPLTSMQMQLYLQQLQKV--QPPTPLLPSVKVQSQPPPPLPPPPHPSVQ 967

  Fly  1225 QRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTY 1265
            |:.:|.. |.||.||.|....:..:.||:....||..|.|:
Human   968 QQLQQQP-PPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTH 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600	5/29 (17%)
		PHD4_KMT2C_like	530..578	CDD:276987	10/65 (15%)
		PHD5_KMT2C_like	580..625	CDD:276988	7/58 (12%)
		PHD6_KMT2C_like	657..707	CDD:276989	11/80 (14%)
		NHP6B	1101..>1237	CDD:227935	23/153 (15%)
		HMG	1173..1231	CDD:197700	11/68 (16%)
BRD4	NP_001366220.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58
		Bromo_Brdt_I_like	58..164	CDD:99929	18/84 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	174..229		11/81 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	242..352		18/136 (13%)
		Bromo_Brdt_II_like	353..454	CDD:99930	16/113 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	463..615		26/163 (16%)
		NPS region	484..503		6/18 (33%)
		BID region	524..579		11/64 (17%)
		BET	609..673	CDD:407211	11/63 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	674..1100		72/407 (18%)
		PRK03427	<809..>922	CDD:235124	24/146 (16%)
		C-terminal (CTD) region	1047..1362
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1116..1339
		BRD4_CDT	1319..1362	CDD:407248
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900