DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lpt and Setd1a

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:NP_821172.2 Gene:Setd1a / 233904 MGIID:2446244 Length:1716 Species:Mus musculus


Alignment Length:850 Identity:150/850 - (17%)
Similarity:264/850 - (31%) Gaps:289/850 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   695 DHYDNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNH 759
            |...::..:|.....|.....|.:|::.|:..|.:.:...|        ||..|.:|.|..|...
Mouse  1023 DEDSDSSSQCSLYADSDGENGSTSDSESGSSSSSSSSSSSS--------SSSSSSESSSEEEEQS 1079

  Fly   760 PTL-SGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKM-RQALGNGKD---GQLEAAA 819
            ..: |...|...||.|...|....::   |::.|....:..|..: .|..|..::   ...:..|
Mouse  1080 AVIPSASPPREVPEPLPAPDEKPETD---GLVDSPVMPLSEKETLPTQPAGPAEEPPPSVPQPPA 1141

  Fly   820 EEALEKYKDGMVWDGTENAIPEGFTISINDE----GVNIL--RKKRQRNLQKLGIGGFSVRNRGL 878
            |...          |..:|.|.      .||    .:.:|  .|||::.:      .||......
Mouse  1142 EPPA----------GPPDAAPR------LDERPSSPIPLLPPPKKRRKTV------SFSAAEEAP 1184

  Fly   879 KKDSEETTAVDQINSLMTMDKKKKIIRKKQKN------KLIEAYPVYLQEAFFGKPLLEGGELVM 937
            ..:......:...:|.....|..:::.:..:|      .|::::|   :|...|.....||.:..
Mouse  1185 VPEPSTAAPLQAKSSGPVSRKVPRVVERTIRNLPLDHASLVKSWP---EEVARGGRNRAGGRVRS 1246

  Fly   938 AD----TDSSDEIDASM----------KVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTE 988
            .:    |:|..|:|.::          :...|.|.|......:|....:.|:..:..:..|   .
Mouse  1247 TEEEEATESGTEVDLAVLADLALTPARRGLATLPTGDDSEATETSDEAERPSPLLSHILLE---H 1308

  Fly   989 NKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVP 1053
            |..:.|:..|        |||.....:|..|            |.||.|.              |
Mouse  1309 NYALAIKPPP--------TTPAPRPLEPAPA------------LAALFSS--------------P 1339

  Fly  1054 SAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQAPQNANKQNM 1118
            :.||:     |:|.|:|..                       ...|.||||  ||.|        
Mouse  1340 ADEVL-----EAPEVVVAE-----------------------AEEPKQQLQ--QQHP-------- 1366

  Fly  1119 QTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLYANTEHPNL 1183
                       |:..|||::..|..:|:..:.:..::     ||:..:                 
Mouse  1367 -----------EQEGEEEEEDEEEESESSESSSSSSS-----DEEGAI----------------- 1398

  Fly  1184 KELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQ-----EE 1243
                            |.|||               ||..|:||.....|.||.|..:     |:
Mouse  1399 ----------------RRRSL---------------RSHTRRRRPPLPPPPPPPPSFEPRSEFEQ 1432

  Fly  1244 MG---RVWKQPPKLKEDQPNMFVTYNGNAYDMGNYVGGSAQAASNNP--NPHHVMPNVNDNLVIK 1303
            |.   .:|.....| ||...:.:||.           ...|..|...  |..|.:.:...||...
Mouse  1433 MTILYDIWNSGLDL-EDMSYLRLTYE-----------RLLQQTSGADWLNDTHWVQHTITNLSTP 1485

  Fly  1304 ATMQRTQ----VHTTAAS------TLKMTTVDNRLELNTAVYGTEPIGDKKL---------RNLL 1349
            ...:|.|    .|.|.::      .:.....|..|::.       |:..::|         |.|.
Mouse  1486 KRKRRPQDGPREHQTGSARSEGYYPISKKEKDKYLDVC-------PVSARQLEGGDTQGTNRVLS 1543

  Fly  1350 QKNSTEPMLMGA-NSDLFLGNDVMRLGMMQNTPITQNNPMLSISGKSQPSEGRSLEQDVKLGEPQ 1413
            ::.|.:..|:.| .:...:.:|:::|..::             ..|.:...|||...:..|...:
Mouse  1544 ERRSEQRRLLSAIGTSAIMDSDLLKLNQLK-------------FRKKKLRFGRSRIHEWGLFAME 1595

  Fly  1414 EATSSAVELENVGFSDLLGGLGEGDDDDLLKSLTSEMGDDFNILEYADPELDVNVLNSLDFD--- 1475
            ...:..:.:|.||.:              ::.:.::|.:.    .|....:..:.|..:|.|   
Mouse  1596 PIAADEMVIEYVGQN--------------IRQMVADMREK----RYVQEGIGSSYLFRVDHDTII 1642

  Fly  1476 DNEKC 1480
            |..||
Mouse  1643 DATKC 1647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135
PHD1_KMT2C_like 205..250 CDD:276984
PHD2_KMT2C_like 252..298 CDD:276985
PHD_SF 337..392 CDD:304600
PHD4_KMT2C_like 530..578 CDD:276987
PHD5_KMT2C_like 580..625 CDD:276988
PHD6_KMT2C_like 657..707 CDD:276989 2/11 (18%)
NHP6B 1101..>1237 CDD:227935 26/135 (19%)
HMG 1173..1231 CDD:197700 9/57 (16%)
Setd1aNP_821172.2 RRM_Set1A 92..186 CDD:240992
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..367
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..499
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 516..670
Topoisomer_IB_N <835..>883 CDD:322080
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 849..869
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 911..1206 39/215 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1230..1259 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1275..1297 4/21 (19%)
HCFC1-binding motif (HBM). /evidence=ECO:0000250|UniProtKB:O15047 1307..1311 2/6 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1355..1427 29/145 (20%)
Interaction with CFP1. /evidence=ECO:0000250|UniProtKB:O15047 1424..1459 8/46 (17%)
N-SET 1434..1571 CDD:314603 27/155 (17%)
Interaction with ASH2L, RBBP5 and WDR5. /evidence=ECO:0000250|UniProtKB:O15047 1459..1546 16/93 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1480..1508 6/27 (22%)
WDR5 interaction motif (WIN). /evidence=ECO:0000250|UniProtKB:O15047 1501..1506 0/4 (0%)
SET 1577..1700 CDD:214614 14/88 (16%)
PostSET 1700..1716 CDD:214703
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

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