DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Kmt2c

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_006535745.1	Gene:	Kmt2c / 231051	MGIID:	2444959	Length:	4976	Species:	Mus musculus

Alignment Length:	1726	Identity:	445/1726 - (25%)
Similarity:	648/1726 - (37%)	Gaps:	558/1726 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STNVVVSMEEKAVADDLPYFPEKFPGKVCCLCNLGEKSALGQGEILQLKA-----------PAPA 55
            |.|.:||:..:|          |...::|..|..||||:||||::.|.:.           |:..
Mouse   117 SANSLVSVGVEA----------KISEQLCAFCYCGEKSSLGQGDLKQFRVTPGLTLPWKDQPSNK 171

  Fly    56 EIKD----------KYPTDRLREDGSRLLYGPKQAASS-------------SGDCHYELDKIGQP 97
            :|.|          .|...:.|  |.|....|:|:|.|             :|....||..:|.|
Mouse   172 DIDDNSSGTCEKIQNYAPRKQR--GQRKERPPQQSAVSCVSVSTQTACEDQAGKLWDELSLVGLP 234

  Fly    98 DVVHPAEFLDE-GFVYVHRMCIMWSLRKSQISD-----ADGAYFATHFAEFLEQKCNFCGRYGAS 156
            |.:......|. |..:.|..|:.|||...|:.:     .|.|..:..     .::|.||...||:
Mouse   235 DAIDVQALFDSTGTCWAHHRCVEWSLGICQMEEPLLVNVDKAVVSGS-----TERCAFCKHLGAT 294

  Fly   157 IN-CKMNCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSLGDLSKLIM 220
            |. |:..|.|::|:||||.||.......|.:.|.||:.|.|. .|..:..|..|.|.|||.....
Mouse   295 IKCCEEKCTQMYHYPCAAGAGTFQDFSHFFLLCPEHIDQAPE-RSKEDANCAVCDSPGDLLDQFF 358

  Fly   221 CSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKCEQCQKTYHASCLRPVI 285
            |:|||.|:|..|:.:|..|..|:||.|..|..||.|: |...|:|.:.|:.|.|.||..||:||:
Mouse   359 CTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCK-QSGEDSKMLVCDTCDKGYHTFCLQPVM 422

  Fly   286 SAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPICQKAYRAASHK 350
            .::|..||||..||:|.:||:|     ||::||.:..|||:||||::.  .||.|.|.|.....|
Mouse   423 KSVPTNGWKCKNCRICIECGTR-----SSTQWHHNCLICDTCYQQQDN--LCPFCGKCYHPELQK 480

  Fly   351 EMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCK---------------------- 393
            :|:.|:.|.::||..||:..|.....:.||     ||:|..||
Mouse   481 DMLHCNMCKRWVHLECDKPTDQELDSQLKE-----DYICMYCKHLGAEIDPLHPGNEVEMPELPT 540

  Fly   394 ----------------------------------------------SNSSGPGSSQQTIDSIVLS 412
                                                          ...|.|..|..|:..|...
Mouse   541 DYASGMEIEGTEDEVVFLEQTVNKDVSDHQCRPGIVPDAVQVYTEEPQKSNPLESPDTVGLITSE 605

  Fly   413 AMDS------------------------------------------------------------- 416
            :.|:
Mouse   606 SSDNKMNPDLANEIAHEVDTEKTEMLSKGRHVCEEDQNEDRMEVTENIEVLPHQTIVPQEDLLLS 670

  Fly   417 -----------------------------SSEQLSLKE--------------------------- 425
                                         |...||.||
Mouse   671 EDSEVASKELSPPKSAPETAAPEALLSPHSERSLSCKEPLLTERVQEEMEQKENSEFSTGCVDFE 735

  Fly   426 -------------------IELDPLEGKPTMD--------------------PSSDELHKLPTG- 450
                               :|| |.|.:.|..                    ||.|.||..|..
Mouse   736 MTLAVDSCDKDSSCQGDKYVEL-PAEEESTFSSATDLNKADVSSSSTLCSDLPSCDMLHGYPPAF 799

  Fly   451 ---------------------------KKKVCLTSVRGRSGKFVLH------------------- 469
                                       |:|......|.:.|.:..|
Mouse   800 NSAAGSIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSNHNTVSPPSWAPDTSEGREIF 864

  Fly   470 -------------RMGVMSQINKKRSTR--------GKGRQ--------LALPTISSDRCLSRSM 505
                         ::|..|....||..|        |:||.        :.||.:|:....|...
Mouse   865 KPRQLSGSAIWSIKVGRGSGFPGKRRPRGAGLSGRGGRGRSKLKSGIGAVVLPGVSAADISSNKD 929

  Fly   506 ETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQ 570
            |.:.:....::|.|:.|||...||:||:|||.|..::..::.|:||||||||||..:|.::.:|.
Mouse   930 EEENSMHNTVVLFSSSDKFTLQQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVVLS 994

  Fly   571 KGWRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNP 635
            ||||||:|||||.|||..|..||||||:||||||.||::|||:|||.|.|||.:|..|:.||...
Mouse   995 KGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATS 1059

  Fly   636 TEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNN 700
            ........:|..:|..|.|.||||||..:|...::|:||..|:.|.|..|.::|.:..:::..:.
Mouse  1060 AGLRCEWQNNYTQCAPCASLSSCPVCCRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADI 1124

  Fly   701 VYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHIT-ASSGPSFDSKSGAERNHPTLSG 764
            .:.|..||                            |::.:: ..|....||...|:     :..
Mouse  1125 GFDCSMCR----------------------------PYMPVSNVPSSDCCDSSLVAQ-----IVT 1156

  Fly   765 DMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQAL---------------------G 808
            .:.|..|...:..|||||:|||:..::||:....|:::.:..|                     .
Mouse  1157 KVKELDPPKTYTQDGVCLTESGMSQLQSLTVTAPRRKRTKPKLKLKIINQNSVAVLQTPPDIQSE 1221

  Fly   809 NGKDGQLEAAAEEALEKYKDGMVWDGTENAIPE---GFTISINDEGVNILRKKRQRNLQKLGIGG 870
            :.:||:::.:.|..|      |..||...:.||   |...:...||.:.: |||:|...:.||||
Mouse  1222 HSRDGEMDDSREGEL------MDCDGKSESSPEREAGDDETKGIEGTDAI-KKRKRKPYRPGIGG 1279

  Fly   871 FSVRNRG-----------LKKDSEET------------------TAVDQ-INSLMTMDKKKKIIR 905
            |.||.|.           ::|||..:                  |.||: ::.....||.||..|
Mouse  1280 FMVRQRSRTGQGKAKRSVVRKDSSGSISEQLPSRDDGWREQLPDTLVDEPVSVAENTDKIKKRYR 1344

  Fly   906 KKQKNKLIEAYPVYLQEAFFGKPLLEGG--ELVMADTDSSDEIDASMKVYFTRP-------EGKS 961
            |: ||||.|.:|.|||||||||.||:..  ..:..|..|.|....|.|..|..|       ...:
Mouse  1345 KR-KNKLEETFPAYLQEAFFGKDLLDTSRQNKLSVDNLSEDAAQLSFKTGFLDPSSDPLLSSSST 1408

  Fly   962 PANQDTLAVNKSPAKTVKKVKAELKTENKTVFI--QQMPMGIQNKN--------GTTPVSNVFDP 1016
            .|...|......|...:.:|   |.|::..:.|  ..:...:.:..        |::|......|
Mouse  1409 SAKPGTQGTADDPLADISEV---LNTDDDILGIISDDLAKSVDHSGLDLCTFQVGSSPFPLDIGP 1470

  Fly  1017 LQAEISNT----VFANRHP-----LDALASP----------------NVPEL---DMANSVSTVP 1053
            ..|:.|:.    |..:..|     ||.:.||                .:|||   |:.:..:.|.
Mouse  1471 TTADASSLPQPGVSQSSRPLTEEQLDGILSPELDKMVTDGAILGKLYKIPELGGKDVEDLFTAVL 1535

  Fly  1054 SAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGG----NTLVNPAQQLQFRQQAPQNAN 1114
            |      |....||.|..    |...||....|||.....    |.|:.|:..|......|.:..
Mouse  1536 S------PATTQPAPLPQ----PPPPPQLLPMHNQDVFSRMPLMNGLIGPSPHLPHNSLPPGSGL 1590

  Fly  1115 KQNMQTIMSQVVLQTEKRP------EEEQKVVEPVTETLN------AGTQKTAEKMRKDEDLGLM 1167
            ........|......:|.|      .:......|.|.::.      :..|::..|..|:|.||.|
Mouse  1591 GTFPAIAQSPYTDVRDKSPAFNAIASDPNSSWAPTTPSMEGENDTLSNAQRSTLKWEKEEALGEM 1655

  Fly  1168 ATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALR-------- 1224
            ||::.|||.|...|||||.||.|..|.|||.|.||...::::||::|||:|||:|||
Mouse  1656 ATVAPVLYTNINFPNLKEEFPDWTTRVKQIAKLWRKASSQERAPYVQKARDNRAALRINKVQMSN 1720

  Fly  1225 --QRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQ 1258
              .:|:|.:..:.|..:...::   :|.|.|.:|.:
Mouse  1721 DSMKRQQQQDSIDPSSRIDSDL---FKDPLKQRESE 1753

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135	27/87 (31%)
		PHD1_KMT2C_like	205..250	CDD:276984	19/44 (43%)
		PHD2_KMT2C_like	252..298	CDD:276985	20/45 (44%)
		PHD_SF	337..392	CDD:304600	19/54 (35%)
		PHD4_KMT2C_like	530..578	CDD:276987	25/47 (53%)
		PHD5_KMT2C_like	580..625	CDD:276988	31/44 (70%)
		PHD6_KMT2C_like	657..707	CDD:276989	15/49 (31%)
		NHP6B	1101..>1237	CDD:227935	48/157 (31%)
		HMG	1173..1231	CDD:197700	32/67 (48%)
Kmt2c	XP_006535745.1	PHD2_KMT2C	390..435	CDD:277069	20/45 (44%)
		PHD3_KMT2C	466..517	CDD:276986	19/55 (35%)
		PHD4_KMT2C	947..1003	CDD:277071	29/55 (53%)
		PHD5_KMT2C_like	1004..1050	CDD:276988	31/45 (69%)
		RanBP2-type Zn finger	1079..1101	CDD:275375	10/21 (48%)
		PHD6_KMT2C	1081..1131	CDD:277073	15/49 (31%)
		HMG-box	1661..1712	CDD:381793	28/50 (56%)
		Tma16	1699..>1782	CDD:371407	17/58 (29%)
		PHA03247	<1880..2370	CDD:223021
		PHA03247	<2146..2753	CDD:223021
		PKK	3189..3275	CDD:372134
		Atrophin-1	3288..>3590	CDD:367360
		ePHD2_KMT2C	4467..4571	CDD:277167
		FYRN	4616..4667	CDD:368685
		FYRC	4673..4757	CDD:368686
		SET_KMT2C_2D	4823..4975	CDD:380948
		ePHD1_KMT2C	247..330	CDD:277166	27/87 (31%)
		PHD1_KMT2C_like	343..388	CDD:276984	19/44 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3959
eggNOG	1	0.900	-	-		E2759_KOG4443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	642	1.000	Inparanoid score	I807
Isobase	1	0.950	-	0	Normalized mean entropy	S6807
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002860
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102575
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X2220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.830