DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and SETD1B

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:NP_001340274.1 Gene:SETD1B / 23067 HGNCID:29187 Length:1966 Species:Homo sapiens


Alignment Length:787 Identity:150/787 - (19%)
Similarity:252/787 - (32%) Gaps:231/787 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   727 SLAITPQGSKP-----------------FVHITASSGPSFDSKSGAERNH--PTL---------S 763
            |..:|.||:.|                 ||::....||...|.||..|..  |.|         .
Human   783 SRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRGPFSLSNSGPGRGQHWPPLPKFDPSVPPP 847

  Fly   764 GDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKR--KRKMRQALGNGKDGQLEAAAEEALEKY 826
            |.||.........:|||.|.     ::|.|...:||  .|||           :|..|..|.:::
Human   848 GYMPRQEDPHKATVDGVLLV-----VLKELKAIMKRDLNRKM-----------VEVVAFRAFDEW 896

  Fly   827 KDGMVWDGTENAIPEGFTISINDEGVNILRKKRQRNLQK------------------LGIG---- 869
                 ||..|.......|...:.|..:..|.|.:..:..                  ||||    
Human   897 -----WDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGA 956

  Fly   870 ----GFSVRNR--------GLKKDSEETTAVDQINSLMTMDKKK-------KIIRKKQKNKLIEA 915
                .|.|:.:        |.:|....:|:||:.:.....::.:       ::.::..|...:..
Human   957 IRLPSFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRR 1021

  Fly   916 YPVYLQEAFFGKPL-LEGGELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVK 979
            .|        .:|| |:.|    .:.|..:.:.||.....:...|.|..:..:.|.:|...:...
Human  1022 RP--------ARPLELDSG----GEEDEKESLSASSSSSASSSSGSSTTSPSSSASDKEEEQEST 1074

  Fly   980 KVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVP--- 1041
            :.:.|.:.|.:    :::|....:.:.|:..|:..|............|.....||:..:..   
Human  1075 EEEEEAEEEEE----EEVPRSQLSSSSTSSTSDKDDDDDDSDDRDESENDDEDTALSEASEKDEG 1135

  Fly  1042 ELDMANSVSTVPS-AEV-----------IEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGN 1094
            :.|...:||.|.| ||.           .|.....||:...|...|..:..:|::...:: :...
Human  1136 DSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEM-VAEE 1199

  Fly  1095 TLVNPAQQLQFRQQAPQNANKQNMQTIMS-----QVVLQTEK-RPEEEQKVV-EPVTETLNAGTQ 1152
            ::.:...: .|.|...:.|.......:.|     :|.::||. .|||...:: ||   .|..|.:
Human  1200 SMASAGPE-DFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEP---PLPVGVE 1260

  Fly  1153 KTAEKMRKDEDLGLMATISAVLYANTEHPNLKELF---PIWNDRCKQILKRWRSLCNEKKAPFLQ 1214
            :.|:.....|:.||....:.:|   :..|..||:.   |:..:|..:     ..|..|.:.|.:.
Human  1261 EPADSREPPEEPGLSQEGAMLL---SPEPPAKEVEARPPLSPERAPE-----HDLEVEPEPPMML 1317

  Fly  1215 KAKDNRSALRQRREQNKIPMPPKPQKQEE---MGRVWKQPPKLKEDQPNMFVTYNGNAYDMGNYV 1276
            ..     .|:......:.|.||.|..:.|   .......|..|.||.|                 
Human  1318 PL-----PLQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHP----------------- 1360

  Fly  1277 GGSAQAASNNPNPHHVMPNVNDNLVIKATMQRTQVHTTAASTLKMTTVDNRLELNTAVYGTEPIG 1341
                        ||  .|.:..:|   |..|.|:   |..:|                    |.|
Human  1361 ------------PH--TPGLCGSL---AKSQSTE---TVPAT--------------------PGG 1385

  Fly  1342 DKKLRNLLQKNSTEPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPMLSISGKSQP-SEGRSLEQ 1405
                         ||.|.|.:|.|.|.:.     .:..:|.:...|..|:|....| :.||....
Human  1386 -------------EPPLSGGSSGLSLSSP-----QVPGSPFSYPAPSPSLSSGGLPRTPGRDFSF 1432

  Fly  1406 DVKLGEP 1412
            .....||
Human  1433 TPTFSEP 1439

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135
PHD1_KMT2C_like 205..250 CDD:276984
PHD2_KMT2C_like 252..298 CDD:276985
PHD_SF 337..392 CDD:304600
PHD4_KMT2C_like 530..578 CDD:276987
PHD5_KMT2C_like 580..625 CDD:276988
PHD6_KMT2C_like 657..707 CDD:276989
NHP6B 1101..>1237 CDD:227935 30/145 (21%)
HMG 1173..1231 CDD:197700 10/60 (17%)
SETD1BNP_001340274.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
RRM_Set1B 101..193 CDD:240993
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 235..302
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 357..660
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..719
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 963..1462 106/586 (18%)
Trypan_PARP <1237..1308 CDD:330686 19/81 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1501..1541
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1555..1606
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1668
N-SET 1679..1821 CDD:314603
WDR5 interaction motif (WIN). /evidence=ECO:0000269|PubMed:22266653, ECO:0000269|PubMed:22665483 1745..1750
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1767..1800
SET 1834..1949 CDD:214614
PostSET 1950..1966 CDD:214703
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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