DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Setd1b

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_006530300.1	Gene:	Setd1b / 208043	MGIID:	2652820	Length:	1986	Species:	Mus musculus

Alignment Length:	643	Identity:	109/643 - (16%)
Similarity:	209/643 - (32%)	Gaps:	195/643 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   727 SLAITPQGSKPF------VHITASSGPSF-------------DSKSGAERNHPTL---------S 763
            |..:|.||:.|:      ....||:|..|             :|..|..::.|.|         .
Mouse   774 SRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRSPFSLSNSGPGRGQHWPPLPKFDPSVPPP 838

  Fly   764 GDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKR--KRKMRQALGNGKDGQLEAAAEEALEKY 826
            |.:|.........:|||.|.     ::|.|...:||  .|||           :|..|..|.:::
Mouse   839 GYIPRQEDPHKATVDGVLLV-----VLKELKAIMKRDLNRKM-----------VEVVAFRAFDEW 887

  Fly   827 KDGMVWDGTENAIPEGFTISINDEGVNILRKKRQRNLQK------------------LGIG---- 869
                 ||..|.......|...:.|..:..|.|.:..:..                  ||||
Mouse   888 -----WDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGA 947

  Fly   870 ----GFSVRNR--------GLKKDSEETTAVDQINSLMTMDKKK-------KIIRKKQKNKLIEA 915
                .|.|:.:        |.:|....:|:||:.:.....::.:       ::.::..|:..:..
Mouse   948 IRLPSFKVKRKEPPDTASSGDQKRLRPSTSVDEEDEESERERDRDIADAPCELTKRDPKSVGVRR 1012

  Fly   916 YPVYLQEAFFGKPL-LEGGELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVK 979
            .|        |:|| |:.|    .:.|..:.:.||.....:...|.|..:..:.|.:|.......
Mouse  1013 RP--------GRPLELDSG----GEEDEKESLSASSSSSASSSSGSSTTSPSSSASDKEEEDRES 1065

  Fly   980 KVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELD 1044
            ..:.|.:.|.:.          :.:....|.|.:..|     |::..:::...|...:.:..::|
Mouse  1066 TEEEEEEEEEEA----------EEEEEEGPRSRISSP-----SSSSSSDKDDEDDNEADSDGQID 1115

  Fly  1045 MANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQA 1109
            ........|.:|..||...:|.....:| :..::.|.|....:....|.:...:.::.    :.:
Mouse  1116 SDIDDQGAPLSEASEKDNGDSEEEETES-ITTSKAPAESSSSSSESSGSSEFESSSES----ESS 1175

  Fly  1110 PQNANKQNMQTIMSQVVLQTEKRPEEEQK--------VVEPVTETLNAGTQKTAEKMRKDEDLG- 1165
            ..::..:...|:..  |.:.|:..|||:|        ||....|::.....:..|:.|.:..||
Mouse  1176 SSSSEDEEEMTVPG--VEEEEEEEEEEEKETAMAAATVVAMAEESMPPAGGQDFEQDRAEVPLGP 1238

  Fly  1166 ------LMATISAV-LYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSAL 1223
                  .:.|...| :.|..|.|                         |.:||.|::......|.
Mouse  1239 RGPMRESLGTEEEVDIEAEDEVP-------------------------EMQAPELEEPPLPMGAR 1278

  Fly  1224 R---------------------------QRREQNKIPMPPKPQKQEEMGRVWKQPPKL 1254
            :                           :..|:.::|.||:...:.::....:.||.|
Mouse  1279 KLEGSPEPPEEPGPNTQGDMLLSPELPARETEEAQLPSPPEHGPESDLDMEPEPPPML 1336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	27/178 (15%)
		HMG	1173..1231	CDD:197700	10/85 (12%)
Setd1b	XP_006530300.1	RRM_Set1B	100..192	CDD:240993
		N-SET	1698..1841	CDD:371711
		SET_SETD1	1835..1982	CDD:380946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030