DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Bptf

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_006532738.1	Gene:	Bptf / 207165	MGIID:	2444008	Length:	3158	Species:	Mus musculus

Alignment Length:	1583	Identity:	273/1583 - (17%)
Similarity:	486/1583 - (30%)	Gaps:	546/1583 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 EDGSRLLYGPKQAASSSGDCHYELDKIGQPDVVHPAEFLDEGFVYVHRMCIMWSLRKSQISDADG 132
            ||.|...:||.....|.....|.:|.:..|:|:.         ||    |           ::|.
Mouse   310 EDTSNTTFGPADLKDSVNSTLYFIDGMTWPEVLR---------VY----C-----------ESDK 350

  Fly   133 AYFATHFAEFLEQKCNFCGRYGASINCKMNCRQVHHWPCAAAAGCLLILESF--TVFCTEHLSQV 195
            .|.  |...:.|.:..   .||...| |:...|             .:::.|  |....|.|...
Mouse   351 EYH--HVLPYQEAEDY---PYGPVEN-KIKVLQ-------------FLVDQFLTTNIAREELMSE 396

  Fly   196 PVICSDNNVECLSCSSLGDLSKLIMCSTCGDHFHSTCI--GLANLPDTRSGWNCARCTKCQI--- 255
            .||..|::  |..|..|||   |:.|.||...:|..|:  .|..:|:..  |.|..|...::
Mouse   397 GVIQYDDH--CRVCHKLGD---LLCCETCSAVYHLECVKPPLEEVPEDE--WQCEVCVAHKVPGV 454

  Fly   256 --CRQQDSNDTKYVKCEQC---------------------------QKTYHASC---LRPVISAI 288
              |..:...:..||:.|..                           :|.::.|.   |..:|..:
Mouse   455 TDCVAEVQKNKPYVRHEPIGYDRSRRKYWFLNRRLIIEEDTDNENEKKVWYYSTKVQLAELIDCL 519

  Fly   289 PKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPICQKAYRAASHKEMV 353
            .|..|:...|||..|.         ......|..:.:..   .||...   ..|::.||:::|::
Mouse   520 DKGYWEAELCRVLEDI---------REEMQQHMDVTEDL---TNKARG---SNKSFLAAANEEIL 569

  Fly   354 KCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSS 418
            ......:.....||:          ..::|:        |....|..:|.:..:.....|.|.|:
Mouse   570 DSLRIKRGEDIDCDQ----------SPEDPE--------KDKHEGENNSSKDAEKSREEAEDPSA 616

  Fly   419 EQ-LSLKEIELDPLEGKPTMDPSSDELHKLPTGKKKVCLTSVRGRSGKFVLHRMG-VMSQINKKR 481
            :: ...|.:|.:|..|||. :|                 |.| |..|..|...:| ..:..:.:.
Mouse   617 DKDADSKGLEEEPGHGKPE-EP-----------------TEV-GDKGNSVPANLGDNTTNASPEE 662

  Fly   482 STRGKGRQLALPTISSDRCLSRSMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMI 546
            ::...||       |.:.|||.:.::...::||:......|....:...|        :|.:...
Mouse   663 TSPCDGR-------SPEGCLSETHDSSSMAEKKVASELPPDVPEDSNRTC--------DSSNTSA 712

  Fly   547 TCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCEGCGKKNDEARLLLCDECDI---------- 601
            |.|.              |:..|:      .|:..|....::|.|:  ..|:.:|
Mouse   713 TTAS--------------SQPNLE------TCSSSELTSSQSDSAK--AADDPEIGERDSHTPVS 755

  Fly   602 ------SYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPV 660
                  .:.:...|..:...|......|..|......|||       :|.:.:..|....::...
Mouse   756 VHEEIGDFRLEKSNGEVSESPGAGKGTSGSTRIITRLRNP-------ESKLSQLKSQQVAAAAHE 813

  Fly   661 CKVSYSNGEMII----QCEHCELWAHFHCDSVNAQLTIDHYDNNVYKC-----FKCRCSTRSTNS 716
            ....:..|:.::    |.|...|       |...::.:....||.:|.     ::...:..||||
Mouse   814 ANKLFKEGKEVLVVNSQGEVSRL-------STKKEVVMKGNINNYFKLGQEGKYRVYHNQYSTNS 871

  Fly   717 LADAKFGNED----------SLAITPQGSKPFVHITASSGPSFDSK-----------SGAERNHP 760
            .|..|..:.:          ...:||.|...:      :|....||           :..|.|.|
Mouse   872 FALNKHQHREDHDKRRHLAHKFCLTPAGEFKW------NGSVHGSKVLTISTLRLTITQLESNIP 930

  Fly   761 TLSGDMPESAPEALHWIDGVCLSES------GLGMIKSLSTEIKRKRKMRQALGNGKDGQLEAAA 819
            : |...|..|....:||..|.:...      .|.:::.....:......|::||:.:..::.:..
Mouse   931 S-SFLHPNWASHRANWIKAVQMCSKPREFALALAILECAVKPVVMLPIWRESLGHTRLHRMTSIE 994

  Fly   820 EEALEKYKDGMVWDGTENAIPEG----FTISINDEGVNILRKKRQRNLQKLGIGGFS-------- 872
            .|..||.|........|..:.:.    :|..:..:    :.|::....:..|.||:|
Mouse   995 REEKEKVKKKEKKQEEEETMQQATWVKYTFPVKHQ----VWKQKGEEYRVTGYGGWSWISKTHVY 1055

  Fly   873 -----------VRNR----GLKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQE 922
                       |..|    |.|.:::|..  |:       .:|:|..|..:|.|
Mouse  1056 RFLPKLPGNTNVNYRKPLDGAKNNTDENK--DE-------SEKRKSPRSPKKMK----------- 1100

  Fly   923 AFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKT 987
                         ...|::..:..||         :..:.|....:.::|.|.|..:.||..|.:
Mouse  1101 -------------TECDSEQGETRDA---------DATAGAAAGAMELSKEPEKKDQDVKELLDS 1143

  Fly   988 ENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTV 1052
            :|...| ::.||                    ||.:|:....|                  ||::
Mouse  1144 DNDKSF-KEEPM--------------------EIDDTIKTESH------------------VSSL 1169

  Fly  1053 PSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQAPQNANKQN 1117
            .|.||                                     .:||.::....|....:......
Mouse  1170 ESTEV-------------------------------------DVVNVSEGFHLRTSYKKKTKSSK 1197

  Fly  1118 MQTIMSQVVLQ---TEKRPEEEQKVVEPV------------TETLNAGTQKTAE-----KMRKDE 1162
            :..::.:.:.|   .||:..|:.|:...|            :.:.:.|:.|.:|     .:|:::
Mouse  1198 LDGLLERRIRQFTLEEKQRLEKLKLESGVKGAGKPPMGALKSSSESPGSTKASEGHQGDSLRQEQ 1262

  Fly  1163 ----------DLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAK 1217
                      ||||..:.|..|......|:|....|   |...|:|.   .:..:...|..|:..
Mouse  1263 SPSSSQASTVDLGLGGSQSDPLVLGISPPSLSTHKP---DPKDQVLD---DVSIQSPGPNCQRQN 1321

  Fly  1218 DNRSALRQR----------REQNKIPM------PPKPQKQEEMGRVWKQPPKL-KEDQPNMFVTY 1265
            ...|.|..|          ..|.|..:      ..||...:::|.:..:..|| .:|..:..|:.
Mouse  1322 SVESDLDARISEPAGKGLELSQTKTEVTDSSSDDSKPTSADDVGILICKSRKLHSQDDSSTVVSS 1386

  Fly  1266 N--------------------GNAYDMGNYVGGSAQAASNNPNPHHVMPNVNDNLVIK------- 1303
            :                    ..|.|....:||.::.:|       .:.|.:||:.|:
Mouse  1387 SKSTLPASVPKSPRDRDARAFSKAVDFDGRLGGDSEYSS-------TLENSSDNMCIRDSAEEDM 1444

  Fly  1304 -------ATMQR--------TQVHTTAASTLKMTTVDNRLELNTAVYGTEPIGDK---------- 1343
                   ||.:|        ..|.:|....:..:|.:...:|...|  ||..|.|
Mouse  1445 VVQNSSEATSKRFIAPEQGGESVESTKCQVVSKSTENCEDKLQGKV--TEANGKKLGQHPPKPEE 1507

  Fly  1344 ----------KLRNLLQKNSTEPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPMLSISGKSQPS 1398
                      .||:.:.:.::||            .:..:.|...|        ...|:||...:
Mouse  1508 RAVNRCTDQVSLRHSVDRKNSEP------------RESEKKGQKAN--------KFQINGKDSKA 1552

  Fly  1399 EGRSLEQDVKLGEPQEATSSAVE 1421
            :|.......|.|...:..|||||
Mouse  1553 KGYLKGPGTKDGSDGKVVSSAVE 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135	14/83 (17%)
		PHD1_KMT2C_like	205..250	CDD:276984	15/46 (33%)
		PHD2_KMT2C_like	252..298	CDD:276985	10/80 (13%)
		PHD_SF	337..392	CDD:304600	7/54 (13%)
		PHD4_KMT2C_like	530..578	CDD:276987	6/47 (13%)
		PHD5_KMT2C_like	580..625	CDD:276988	8/60 (13%)
		PHD6_KMT2C_like	657..707	CDD:276989	8/58 (14%)
		NHP6B	1101..>1237	CDD:227935	30/181 (17%)
		HMG	1173..1231	CDD:197700	13/67 (19%)
Bptf	XP_006532738.1	DDT	253..309	CDD:367184
		WHIM1	356..393	CDD:373966	9/53 (17%)
		PHD1_BPTF	404..446	CDD:277034	15/48 (31%)
		WSD	468..536	CDD:373967	12/76 (16%)
		MDN1	<578..749	CDD:227596	43/244 (18%)
		DUF5585	<2038..2345	CDD:375359
		Med15	<2246..>2609	CDD:312941
		TPH	2696..>2836	CDD:372768
		PHD2_3_BPTF	2923..2969	CDD:277035
		PHD2_3_BPTF	2981..3027	CDD:277035
		Bromo_gcn5_like	3043..3143	CDD:99941
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900