DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Ash1l

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_619620.3	Gene:	Ash1l / 192195	MGIID:	2183158	Length:	2958	Species:	Mus musculus

Alignment Length:	1659	Identity:	289/1659 - (17%)
Similarity:	483/1659 - (29%)	Gaps:	694/1659 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 RPVISAIPKYGWKCNRCRVCTD-----CGSRTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPICQ 341
            ||.|....|:..|..:....||     |         .|:|.|                     .
Mouse   108 RPAIKTTIKHSRKALKSGKMTDEKNEHC---------PSKWDS---------------------S 142

  Fly   342 KAYRAASHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNP-----------DYDYV------- 388
            |.::.|.....:.|. ..:.:|           .|.:.|.||           ..||:
Mouse   143 KLFKKAGDATAIDCQ-AEESIH-----------LHSQGESNPLSKKLSPVHSQMADYISAAPSLV 195

  Fly   389 -----------------------------CPNCKSNSSGPGS----------SQQTIDSIVLSAM 414
                                         ||..||:.:.|..          |:..|....:.::
Mouse   196 GSRDPDIKDRALLNGGTSVTEKLAQLIATCPPSKSSKAKPKKLGTGTTVGLVSKDLIRKPGVGSI 260

  Fly   415 DSSSEQLSLKEIELDPLEGKPTMDP-------------SSDELHKLPT-----------GKKKVC 455
            .....:..:|:..|....|..|.||             :.|.:.||.|           |||...
Mouse   261 AGIIHKDLIKKPALSTAVGLVTKDPGKKPMFNAAVGLINKDSVKKLGTGTTAVFINKDLGKKPGA 325

  Fly   456 LTSV---RGRSGKFVLHRMG---VMSQINKKRSTRGKGRQLALPTISS--DRCLSRSMET----- 507
            :|:|   ...|||    ::|   |...:||:     .|::|.|.|:..  ::.|.:.:.:
Mouse   326 ITTVGLLSKESGK----KLGIGIVPGLVNKE-----SGKKLGLGTVVGLVNKELGKKLSSTVGLV 381

  Fly   508 --DLTSDKKLLLCSARDKFIQAQDI------CVMCGSLG------IESDSVMIT----CAQCGQC 554
              |:|  ||::..||..  :..:||      |.|.|.||      ::|::::.|    .|.|...
Mouse   382 AKDVT--KKIVASSAMG--LVNKDIGKKLLNCPMAGQLGSKDALNLKSEALLPTQEQLKASCSAN 442

  Fly   555 YHPYCAGVKP--------------------SRGILQKGWRCLDCTVCEGCGKKNDEARLLLCDEC 599
            ...:.:...|                    ...:|:|.....:.|        |.|..:.....|
Mouse   443 ISNHDSQELPESLKDSATGKAFEKSVMRHSKESMLEKFSVRKEIT--------NLEKEMFNEGTC 499

  Fly   600 --------------DISYH-----IYCVNP---------------PLETVPTGNWKCSFCTL-CQ 629
                          :.|.|     :||.:|               |...|...|...|..|: ..
Mouse   500 IQQDNFSSSERGAFETSKHEKQPPVYCTSPDFQIGGASDASTAKSPFSAVGESNLPSSSPTVSVN 564

  Fly   630 KCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTI 694
            ...|:|.|.|    |.::..|...:.::..:.::|.|.|:           :.|..:|.:  |.:
Mouse   565 PVTRSPPEAS----SQLVPNPLLLNSTAEQMEEISESIGK-----------SQFTAESTH--LNV 612

  Fly   695 DHYDNNVYKCFKCRCSTRSTNSLAD---------AKFGNEDSL-------AITPQ--------GS 735
            .|.........:|:...:..|...:         :..|.:.||       ||||.        .:
Mouse   613 GHRSLGHSLSIECKGIDKELNESKNTHLDIPRISSSLGKKPSLTSDSGIHAITPSVVNFTSLFSN 677

  Fly   736 KPFVHITASSGP------------SFDSKSGAERNHPTLSGDMPESAPEALHWIDGV----CLSE 784
            |||:.:.|.:.|            ||.||...:|     .|..|       .|...|    |.|.
Mouse   678 KPFLKLGAVTAPDKHCQVAESLSSSFQSKPLKKR-----KGRKP-------RWTKVVARSTCRSP 730

  Fly   785 SGLG-----MIKSLS----TEIKRKRKMRQALG----------NGKDGQLEAAAEEALEKYKDGM 830
            .||.     :.|::|    :......|..:.:|          ..:..:|..::..:|....|
Mouse   731 KGLDLERSELFKNVSCSSLSNSSEPAKFMKTIGASSFVDHDFLKRRLPKLSKSSAPSLALLTD-- 793

  Fly   831 VWDGTENAIPEGFTIS--------INDEGVNILRKKRQRNLQK------------LGIGGFSVRN 875
                :|....:.|...        .:|...:|.:.||.|...|            |.|....|.:
Mouse   794 ----SEKPSHKSFITHKLSSSMCVTSDLLSDIYKPKRGRPKSKEMPQLEGPPKRTLKIPASKVFS 854

  Fly   876 RGLKKDSE--------ETTAVDQINSLMTMDKK----KKIIRK--KQKNKLIEAYPVYLQEA--- 923
            ...|::.|        |..:..|..|:....||    |:.:|.  |.|..::...|....|:
Mouse   855 LQSKEEQEPPILQPEIEIPSFKQSLSVSPFPKKRGRPKRQMRSPVKMKPPVLSVAPFVATESPSK 919

  Fly   924 -------------FFGKPLLEGGELVMADTDSSDEID----ASMKVYFTRPEGK-SPANQDTLAV 970
                         ||      ..|..:.|||..|:..    .||......|:.| |..|...|
Mouse   920 LESESENHRSSSDFF------ESEDQLQDTDDLDDSHRQSVCSMSDLEMEPDKKISKRNNGQL-- 976

  Fly   971 NKSPAKTVKKVKAELKT-ENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFA------- 1027
                .||:.:...::|| :.|.:..|.:...:::.|.        ..:|:::.|||.:
Mouse   977 ----MKTIIRKINKMKTLKRKKLLNQILSSSVESSNK--------GKVQSKLHNTVSSLAATFGS 1029

  Fly  1028 --------------------NRHP---LDALASPNVPELDMANSV------------------ST 1051
                                .|.|   |:.|.|.:...|.:....                  |.
Mouse  1030 KLGQQINVSKKGTIYIGKRRGRKPKTVLNGLLSGSPASLAVLEQTAQQAAGSALGQILPPLLPSP 1094

  Fly  1052 VPSAEVIEKPM---------RESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQ 1107
            ..|:|::..|:         .:||......|:.|:.:|         ||.    |:..|....:.
Mouse  1095 ASSSEILPSPICSQSSGTSGGQSPVSSDAGFVEPSSVP---------YLH----VHSRQGSMIQT 1146

  Fly  1108 QAPQNANK-----------QNMQTIMSQVVLQTEKRPEEEQKVVEPVTE--------------TL 1147
            .|.:.|:|           .|..:.:|::....|..|       .||:|              |.
Mouse  1147 LAMKKASKGRRRLSPPTLLPNSPSHLSELTSLKEATP-------SPVSESHSDETIPSDSGIGTD 1204

  Fly  1148 NAGTQKTAEKM-------RKDEDLGLM-ATISAVLYANTEHPNLKELFPIWNDRCK--------- 1195
            |..|...|||.       ...|.:.|: ...|.||      .:|||..   ..:||
Mouse  1205 NNSTSDRAEKFCGQKKRRHSFEHISLIPPETSTVL------NSLKEKH---KHKCKRRSHDYLSY 1260

  Fly  1196 --------QILKRWRSLCNEKKAPFLQKAKDNRSALRQRREQNK--------------------- 1231
                    :..|::..|.|.:...|:.:.::..|.|.:.|..::
Mouse  1261 DKMKRQKRKRKKKYPQLRNRQDPDFIAELEELISRLSEIRITHRSHHFIPRDLLPTIFRINFNSF 1325

  Fly  1232 -----IPMPP-----KPQKQEEMGRVWKQPPKLKEDQPNM--------------FVTYNGNAYD- 1271
                 .|:.|     ||..:::.||    |||::|....|              |....|..|.
Mouse  1326 YTHPSFPLDPLHYIRKPDLKKKRGR----PPKMREAMAEMPFMHSLSFPLSSTGFYPSYGMPYSP 1386

  Fly  1272 ---------MGNYVGGSAQAASNNPNPH--------------HVMPNVNDNLVIKATMQRTQVHT 1313
                     :|.|...........|:|.              |::.|.......|..:.|.:...
Mouse  1387 SPLTAAPIGLGYYGRYPPTLYPPPPSPSFTTPLPPPSYMHAGHLLLNPTKYHKKKHKLLRQEAFL 1451

  Fly  1314 TAAST--LKMTTV------------------------DNRLE-----------------LNTAVY 1335
            |.:.|  |.|:|.                        ::|.|                 |....:
Mouse  1452 TTSRTPLLSMSTYPSVPPEMAYGWMVEHKHRHRHKHREHRSEQPQVSMDSGSSRSVLESLKRYRF 1516

  Fly  1336 GTEPIGDK-----------------KLRNLLQKN----STEPMLMGANSDLFLGNDVMRLGMMQN 1379
            |.:.:||:                 ..:||:.:.    |.||   ..:|.|.||         ..
Mouse  1517 GKDTVGDRYKHKEKHRCHMSCPHLSPSKNLINREEQWVSREP---SESSSLALG---------LQ 1569

  Fly  1380 TPI----TQNNPMLSISGKSQPSEGRSLEQDVKL 1409
            ||:    ::::|.||:.|.:..||..|.::.:.|
Mouse  1570 TPLQIDCSESSPSLSLGGFTPNSEPASSDEHMNL 1603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985	5/15 (33%)
		PHD_SF	337..392	CDD:304600	12/101 (12%)
		PHD4_KMT2C_like	530..578	CDD:276987	13/83 (16%)
		PHD5_KMT2C_like	580..625	CDD:276988	12/78 (15%)
		PHD6_KMT2C_like	657..707	CDD:276989	7/49 (14%)
		NHP6B	1101..>1237	CDD:227935	36/216 (17%)
		HMG	1173..1231	CDD:197700	14/74 (19%)
Ash1l	NP_619620.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..78
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..137		5/29 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..580		15/78 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	823..843		4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	877..963		19/91 (21%)
		motB	<1061..1187	CDD:183756	23/145 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1094..1126		5/31 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1149..1219		15/76 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1243..1279		6/38 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1579..1599		7/19 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1613..1704
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1722..1754
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1921..1941
		Catalytic domain. /evidence=ECO:0000250	2059..2278
		AWS	2082..2133	CDD:197795
		SET_ASH1L	2136..2276	CDD:380951
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2278..2334
		Bromo_ASH1	2432..2537	CDD:99955
		PHD_ASH1L	2575..2617	CDD:277023
		BAH_polybromo	2654..2788	CDD:240068
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2814..2846
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2861..2909
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030