Protein Alignment Lpt and mes-4

DIOPT Version :9

• Sequence 1: NP_611847.2
• Gene: Lpt / 37795
• FlyBaseID: FBgn0263667
• Length: 1482
• Species: Drosophila melanogaster
• Sequence 2: NP_506333.1
• Gene: mes-4 / 179824
• WormBaseID: WBGene00003222
• Length: 898
• Species: Caenorhabditis elegans
• Alignment Length: 1027
• Identity: 194/1027 - (18%)
• Similarity: 308/1027 - (29%)
• Gaps: 371/1027 - (36%)

  Fly   238 LPDTRSGWNCARCTKCQICRQQDSNDTK--------YVKCEQ--------------CQKTYHASC 280
            |||..|        ||.||.::.....|        |:..|.              |:..:||||
 Worm   122 LPDADS--------KCVICHEEKDKTGKSDLITCHGYINGEMDDGKRLLGNIPMFPCRSKFHASC 178

  Fly   281 LRPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNKGFSCPI-CQKAY 344
            :       ..|                     :|..:|..|.....| |.|   ..||: |..:.
 Worm   179 M-------INY---------------------NSGGFHFQYAARLEC-QAR---LLCPLHCCNSC 211

  Fly   345 RAASHK------EMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCKSNSSGPGSSQ 403
            ....||      ::.:|:.|.:..|.|                              |..|...:
 Worm   212 NLDHHKQSAYVGDIAECALCLRAFHLT------------------------------SCYPSGGR 246

  Fly   404 QTIDSIVLSAMDSSSEQLSLKEIELDPLEGKPTMDPSSDELHKLPTGKKKVCLTSVRGRSGKFVL 468
            ....||.:.......|.:      :.|....|..|......||    |:|..:|.|
 Worm   247 DLNVSITIGGKVEKFEMI------ICPAHYLPGADVQFYNKHK----KRKNAVTVV--------- 292

  Fly   469 HRMGVMSQINKKRSTRGKGRQLALPTISSDRCLSRSMETDLTSDKKLLLCSARDKFIQAQDICVM 533
                                                .:.|:|....:..|            ||
 Worm   293 ------------------------------------PKADVTMKSHIKAC------------CV- 308

  Fly   534 CGSLGIE--SDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCEGCGKKNDEARLLLC 596
               :|.|  |:|..|.|..|.:.:|..|..|:...|......:|..|.    ||....:..|:|.
 Worm   309 ---IGCEKSSNSKTIMCKTCCRSFHSGCREVETLNGKPIPDDQCESCV----CGDPIPQNTLILA 366

  Fly   597 DECDISYHI-----------------------YCV-------------NPPLETVPTGN----WK 621
            ...|.|:.:                       |.|             .|.:..||..:    .|
 Worm   367 KWTDNSFWLALTLDWYKYPTGNRGNINFERLGYTVVQWLIPQENDKEKQPLMSIVPVSDIARLTK 431

  Fly   622 CSFCTLCQKCGRNPTEK--SEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFH 684
            ..|........||..|:  .|..|:.:..||.        |||..:......:         ::.
 Worm   432 NYFSLAKNSTLRNLWEEKYEEQADTALKRCPY--------VCKTVFGRLRTSV---------YYK 479

  Fly   685 CDSVNAQLTIDHYDNN-VYKCFKC-RCSTRSTNSLAD--------AKFG----NEDSLAITPQGS 735
            |:.     .::.|.|| |..|... ||:..|...|||        :|.|    .:.|:.|..:..
 Worm   480 CEP-----KLEEYHNNEVCNCEGADRCTKLSCQYLADDYECPPSCSKKGVCHNRQVSMGIVSEKI 539

  Fly   736 KPFVHITASSGPSFDSKSGAERNHPTLS--GDMPESAPEALHWIDGVCLSES------GLGMIKS 792
            |  :..|...|....:|...|::.....  |::.:.| |....:|.|.:|..      .:.:.|.
 Worm   540 K--LAATLCKGYGVFAKGQIEKDEYICEYVGEIIDKA-EKKRRLDSVSISRDFQANHYMMELHKG 601

  Fly   793 LSTEIKRKRKMRQALGNGKDGQLEAAAEEA-LEKYKDGMVWDGTENAIPEGFTISINDEGVNILR 856
            |:.:..|...:.:.:.:..|....:...:. ::|.|:|.::| |.:.|....||...||......
 Worm   602 LTVDAARYGNISRYINHSCDPNAASFVTKVFVKKTKEGSLYD-TRSYIRAIRTIDDGDEITFSYN 665

  Fly   857 KKRQRNLQK--------LGIGGFSVRNRGLKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNKLI 913
            ...:.||..        :|..|.:.|.:....||.|..|....:|     |||.:..:.:|:
 Worm   666 MNNEENLPDCECGAENCMGTMGKAKREKPEVADSSEKAAKKNKSS-----KKKSVKNQNRKS--- 722

  Fly   914 EAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTV 978
                   |||  ||         ........||              ||:...|
 Worm   723 -------QEA--GK---------NGTASKKSEI--------------SPSKPST----------- 744

  Fly   979 KKVKAELKTENKTVFIQQMPMGI-QN-----KNGTTPVSNVFDPLQAEISNTVFANRH--PLDAL 1035
                   .:.:.|.|:||....| ||     ||...||::.    .:.:|.:...|.|  |.: |
 Worm   745 -------SSASSTSFVQQASWPISQNKKNLKKNSNQPVADT----GSTLSTSTELNFHEKPQE-L 797

  Fly  1036 ASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPA 1100
            .|| |.....|.|.|| |.|:. .|..|:.         |.::.|..::....|    .|:....
 Worm   798 LSP-VSSRSRAASSST-PRAQK-SKSRRDD---------VESEAPPVKRATPSL----QTIQETG 846

  Fly  1101 QQLQF--RQQAPQNANKQNMQTIMSQVVLQ-------TEKRPEEEQKVVEPV 1143
            :.::|  .:.|...|...:.|::.|...::       |..|.::|.|..||:
 Worm   847 KAIEFPATKSAITKARALSTQSVPSPHTVEVKVRAISTRGRVQKETKRFEPI 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984	4/11 (36%)
		PHD2_KMT2C_like	252..298	CDD:276985	13/67 (19%)
		PHD_SF	337..392	CDD:304600	9/61 (15%)
		PHD4_KMT2C_like	530..578	CDD:276987	14/49 (29%)
		PHD5_KMT2C_like	580..625	CDD:276988	12/84 (14%)
		PHD6_KMT2C_like	657..707	CDD:276989	9/50 (18%)
		NHP6B	1101..>1237	CDD:227935	11/52 (21%)
		HMG	1173..1231	CDD:197700
mes-4	NP_506333.1	PHD_SF	207..269	CDD:304600	13/97 (13%)
		SET	537..671	CDD:214614	25/137 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102575
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.930