DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and set-16

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_499819.3	Gene:	set-16 / 176802	WormBaseID:	WBGene00011729	Length:	2475	Species:	Caenorhabditis elegans

Alignment Length:	1387	Identity:	299/1387 - (21%)
Similarity:	466/1387 - (33%)	Gaps:	553/1387 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   300 VCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRNKG-------------FSCPICQKAYRAASHKE 351
            :|.:||...         .::..:|::|......|             .||..||:...|.|.
Worm     2 ICIECGGTA---------FNNTELCENCMDVNRSGTMSLDMARQCDMSSSCGSCQRMITADSR-- 55

  Fly   352 MVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYVCPNCKSNSSGPGSSQQTIDSIVLSA--- 413
              :|:.|.|..|.:|| .:|:::.:         ::||.:|:..      ||...|.::|||
Worm    56 --QCTTCRKSYHLSCD-SSDVSSLN---------NFVCISCRRR------SQMLPDDVMLSASAR 102

  Fly   414 ------------MDSSSEQLSLKEIELDPLEGKPTMDPSSDELH--------------------- 445
                        .|.|..|:|| :::..||   |:..|.|.:.:
Worm   103 PSRGQDAPLSPFSDPSVPQISL-QMQPAPL---PSSYPRSQDFNGDVYTQIAAMQQQRQQQQQNQ 163

  Fly   446 ---------------------------------------------------------KLP----- 448
                                                                     |.|
Worm   164 VQQMLATQAQLMDEISDGGGTNDSDRNSSPFYQEASDYDEDFVPASTRGRGRGGGAKKKPGRGGS 228

  Fly   449 TGKKK---------VCLTSVRGRSGKFV-LHRMGVMSQINKKRSTRGKG---------------- 487
            ||.::         ...|.::..||.|. ||:....|....||..||.|
Worm   229 TGTRRQTNPGPSGFFSATQLQAMSGDFSHLHQPQQTSSTRGKRGKRGNGTSVPRQPGKGPGRGRG 293

  Fly   488 ---------RQLA---------------------------------------------------- 491
                     .|||
Worm   294 RGRGSAAAIAQLAQLQQVQYGAQGAPMFNGAPQLHPTQPTVAPTLPPSVTYQNVAPTAPPAPPAL 358

  Fly   492 -------LPTI--------------SSDRCL-----------SRSMETDLTSDKKLLLCSARDKF 524
                   ||:|              ..|..:           |||.|.:..  :..::|...|:|
Worm   359 QTPLPDPLPSIVPSFQQAPQAVAIREVDELMLEDESSRQSGGSRSDEPEYI--RTAIVCRVNDEF 421

  Fly   525 IQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGV--KPSRGILQKGWRCLDCTVCEGCGKK 587
            :|...:|::|||:|...:..|:.|:.|.|.||.||..:  |.:..::.:||||||||||||||..
Worm   422 LQKACMCLVCGSIGKGPEGSMVACSNCAQTYHTYCVTLHDKLNSAVVGRGWRCLDCTVCEGCGTG 486

  Fly   588 NDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSC 652
            .|||.||||||||:||||||:.|.|:.:|.|.|:|.:|:.|::|.......::.....:  |..|
Worm   487 GDEANLLLCDECDVSYHIYCMKPLLDKIPQGPWRCQWCSRCRRCNHKAASGNDLTSQGL--CFPC 549

  Fly   653 TSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNA-----QLTIDHYDNNVYKCFKCRCSTR 712
            .|...||.|:.:|...|.:|:|..|..|.|..|:.:..     |..||          :.|||..
Worm   550 ASLRKCPRCERNYQLNEKLIRCSQCSKWQHGACEGLYTDEQLEQAAID----------RMRCSAC 604

  Fly   713 STNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMPESAPEALHWI 777
            ....:..:.|.:.|::                                               |.
Worm   605 RPKRVQPSGFSDVDTV-----------------------------------------------WC 622

  Fly   778 DGVCLSESGLGMIKSLSTEIKRKRKMRQALGNGKDGQLEAAAEEALEKYKD--GMVWDGTENAIP 840
            |.|.|.:....::||..|....|..|.:::|          ..|:.:.|.|  ..:.|.::...|
Worm   623 DYVALDKDAHEILKSKYTPSALKNHMMESVG----------YRESFDHYDDDYNPLEDSSDQVTP 677

  Fly   841 EGFTISI---------NDEGVNILRKKRQRNLQKLGIGGFSV---RNRGLKKDSEETTAVDQINS 893
                :.|         |..|        :|.:.::|||||..   |:| ::..:||..|.    :
Worm   678 ----LPIPGQRGRGRGNPSG--------RRGMNRIGIGGFYAKLPRHR-IQALTEEAAAA----A 725

  Fly   894 LMTMDKKK-KIIRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYFTRP 957
            ..:.|.|: |..||.::::|.:|||..:||||||...:||  .|:.||
Worm   726 ASSEDSKQAKRPRKSRRSQLEDAYPPQIQEAFFGIKAVEG--KVLVDT----------------- 771

  Fly   958 EGKSPANQDTLAVNKSPAKTVKKVKA-ELKTENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEI 1021
                |.::..||......|..:..|| ||                        .....:.|:.:|
Worm   772 ----PVDEPFLAEFNGWYKRTRSTKAFEL------------------------CMTASEMLRTDI 808

  Fly  1022 SNTVFANRHPLDALASPNVPELD---------------------MANSVSTVPSAEVIEKPMRES 1065
            ....|     ||.:..||: |.|                     :.||:...|.    ...|:|.
Worm   809 DENEF-----LDCVGLPNM-ETDALDDFDFNLLEDFDVDEENDELENSLLGAPG----NTEMKED 863

  Fly  1066 PAVLVDSFMVPNQLPQEQK---------------FHNQLYLGGNTLVNPAQQLQFRQQAP--QNA 1113
            .|..::....|.....:|:               ||..:        |||   .|.|.||  :||
Worm   864 AAEGIEGSYGPTSFNLDQRPSTSSAGGSLGSQDPFHPGM--------NPA---NFAQHAPGVRNA 917

  Fly  1114 NKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLYANT 1178
                                     :....::|.|:...:.:.:..:||..||.||.:||||:|.
Worm   918 -------------------------IARSGSQTDNSERYQFSARWEEDEPNGLQATTAAVLYSNE 957

  Fly  1179 EHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALRQRREQNKIPMPPKPQKQEE 1243
            :|..|::.||.|.||.|||.|.||:|.:|.:..::.:|:|||:     |..|:    |:|::...
Worm   958 KHGYLRQQFPNWVDRVKQIQKLWRTLNHEVRLDYVNRARDNRT-----RSGNR----PRPRRTNV 1013

  Fly  1244 MGRVWKQPPKLKEDQPNMFVTYNGNAYDMGNYVGGSAQAASNNPN----PHHVMPNVNDNLVIKA 1304
            .......||::....|         |....|.:|.|.|  |..|.    .||:
Worm  1014 QSTDSPPPPQMGFKVP---------ANPSSNMMGSSEQ--SMQPKQVFITHHL------------ 1055

  Fly  1305 TMQRTQVHTTAASTLKMTTVD-NRL------ELNTAVYGTEPIGDKKLRNLLQKNSTEPMLMGAN 1362
            .|...||:    ..||....| .||      :||.|....:.:..|| |.:::..:..|...|.|
Worm  1056 PMDVYQVY----QDLKRVKFDRERLNGSLEEQLNKARKQKKNLAAKK-RQMVKTQTAAPDYDGRN 1115

  Fly  1363 SDLFLGNDVMRLGMMQNTPITQ 1384
            .||...:......:.:...:||
Worm  1116 IDLNESDQQTLATLTEQIKVTQ 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600	14/54 (26%)
		PHD4_KMT2C_like	530..578	CDD:276987	19/49 (39%)
		PHD5_KMT2C_like	580..625	CDD:276988	29/44 (66%)
		PHD6_KMT2C_like	657..707	CDD:276989	14/54 (26%)
		NHP6B	1101..>1237	CDD:227935	40/137 (29%)
		HMG	1173..1231	CDD:197700	24/57 (42%)
set-16	NP_499819.3	PHD_SF	42..84	CDD:276966	15/55 (27%)
		PHD4_KMT2C_like	427..477	CDD:276987	19/49 (39%)
		PHD5_KMT2C_like	479..524	CDD:276988	29/44 (66%)
		PHD6_KMT2C_like	554..604	CDD:276989	17/59 (29%)
		DUF1351	1060..>1163	CDD:284492	20/83 (24%)
		ePHD2_KMT2C_like	1904..2008	CDD:277136
		FYRN	2055..2104	CDD:283589
		FYRC	2112..2199	CDD:197781
		SET	2333..2457	CDD:214614
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	95	1.000	Domainoid score	I4678
eggNOG	1	0.900	-	-		E2759_KOG4443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002860
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_102575
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	1	1.000	-	-		X2220
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.830