DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and C16A11.4

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_494744.2	Gene:	C16A11.4 / 173755	WormBaseID:	WBGene00015817	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	634	Identity:	113/634 - (17%)
Similarity:	238/634 - (37%)	Gaps:	161/634 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   637 EKSEFGDSNMLECPSCTSQSSCPV-----------CKVSYSNGE-MIIQCEHCELWAHFHCDSVN 689
            :.||  ::|..|.|....:|:..|           |:...:|.: .:|:|..||.|.|..|.||
Worm     3 DSSE--EANQFEPPPAIRKSTRAVNNLSPHQKEVRCQCGTNNTDNRLIKCVECEKWQHAICMSV- 64

  Fly   690 AQLTIDHYDNNVYKCFKCR-CSTR---STNSLADAKFGNE-DSLAITPQGSKPFVHITASSGPSF 749
              :.:|     :...:||. |..|   .:.|.|.|..|.| :...:..:|....|::  .....|
Worm    65 --MPLD-----IIMTYKCEMCEPRLLMVSRSQARAYQGVEPEPREVRKKGRNQSVNL--EEFLEF 120

  Fly   750 DSKSGAERNHPTLSGDMPESAPEALHWIDGVCLSESGL--GMIKSLSTE----IKRKRKMRQALG 808
            .|::....:.|.....:.|...|.:::...|.:....|  .:::::|..    ..||.:|..|:|
Worm   121 LSEASENISRPLALTTLFEDYKEHINYPQSVRILRKQLESNLLETISMSPNYYADRKAQMLFAMG 185

  Fly   809 NGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNILRKKRQRNLQKLG---IGG 870
            ....|       |.||:.:        .||:       :..:|.:.:...:.:||:..|   :|.
Worm   186 LRVKG-------EFLERLE--------RNAV-------VEVDGYHRITFYKSKNLEFRGKHRVGR 228

  Fly   871 FSVRNRGLKKDSEETT-----AVDQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQ---EAFFGK 927
            |.:.||  :|.:|.|:     :.::.:..:.:|....:....:.|:    :||..:   |..||.
Worm   229 FPLVNR--RKSAESTSQQHGNSGEEDDDDIFIDLVVPVTGNSRWNQ----FPVKQEIPDEQSFGS 287

  Fly   928 PLLEGGELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTV 992
                      |.|..:.||:.:::...:          ||:....:   :...:.|...:|.:.:
Worm   288 ----------ASTLPNAEIEPNLQYSLS----------DTMTTGSA---STWNMAATPPSEMRGI 329

  Fly   993 FIQQMPMGIQNKNGTTPVSNVFDPLQAE------ISNTVFANRHPLDALASPNVPELDMANSVST 1051
            .::.|       ||...:.:...|...|      :.:|:..:.|.:....|....|:....:::.
Worm   330 MMESM-------NGLHALQSASYPPYQEMQEMLCVQHTMMKSMHEIIKTQSDFYREMFKTRAIAG 387

  Fly  1052 VPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQL-----YLGGNTLVNPAQQLQFRQQAPQ 1111
            .|            ||....|.         :.|.:.|     ||....||:.::..|...:..:
Worm   388 AP------------PAPATTSL---------RAFLHFLKGYVDYLESEQLVDCSRLTQQHLETCR 431

  Fly  1112 NANKQ-NMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLY 1175
            .|:|. :|:.:::.:.:.|    ...:..:..|:..:|..:.....|..:             :|
Worm   432 AADKLISMEKLLTGLAVAT----TIAEAHLSDVSAIINGASAMEFYKFIE-------------IY 479

  Fly  1176 ANTEHPNLKELFPIWNDRCKQILKRWRSLCN-EKKAPFLQKAKDNRSAL 1223
            |:.:..:      .::..|..:.::.::|.| :||.||.:.::..|:|:
Worm   480 ASNQSNS------AFSGLCTDLKQKIQALVNMDKKIPFKELSRAFRTAI 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989	13/61 (21%)
		NHP6B	1101..>1237	CDD:227935	19/125 (15%)
		HMG	1173..1231	CDD:197700	11/52 (21%)
C16A11.4	NP_494744.2	PHD_SF	35..78	CDD:389947	14/50 (28%)
C16A11.4	NP_494744.2	SPK	117..221	CDD:367941	22/125 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030