DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpt and Brd2

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_001191902.1	Gene:	Brd2 / 14312	MGIID:	99495	Length:	798	Species:	Mus musculus

Alignment Length:	344	Identity:	66/344 - (19%)
Similarity:	114/344 - (33%)	Gaps:	98/344 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   975 AKTVKKVKAELKTENKTVFIQQ---MPMGIQNKNGTTPVSN-----VFDPLQAEISNTVFANRHP 1031
            |:|::|           :|:|:   ||...|....|.|.::     ....||..|::.     |.
Mouse   165 AQTLEK-----------IFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSITSA-----HQ 213

  Fly  1032 LDALASPN-----VPELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYL 1091
            :.|::|.:     .|..::..:|..:|...||..|:.:|                       |:.
Mouse   214 VPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKS-----------------------LHS 255

  Fly  1092 GGNTLV-----NPAQQLQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAGT 1151
            .|..|:     .|||.|..::...:.|:    .|..:...:.....|......:||....|....
Mouse   256 AGPPLLAVSAAPPAQPLAKKKGVKRKAD----TTTPTPTAILAPGSPASPPGSLEPKAARLPPMR 316

  Fly  1152 QKTAEKM---RKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKA--- 1210
            :::...:   |||      ...|...:.:::...|.|..    ..|..|||   .|.::|.|
Mouse   317 RESGRPIKPPRKD------LPDSQQQHQSSKKGKLSEQL----KHCNGILK---ELLSKKHAAYA 368

  Fly  1211 -PFLQKAKDNRSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTYNGNAYDMGN 1274
             ||.:....:...|....:..|.||.....|::...|.::...:...|...||    .|.|
Mouse   369 WPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMF----SNCY---- 425

  Fly  1275 YVGGSAQAASNNPNPHHVM 1293
                     ..||..|.|:
Mouse   426 ---------KYNPPDHDVV 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	27/142 (19%)
		HMG	1173..1231	CDD:197700	12/61 (20%)
Brd2	NP_001191902.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	53..72
		Bromo_Brdt_I_like	73..179	CDD:99929	5/24 (21%)
		PHA03247	<215..332	CDD:223021	25/149 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..348		15/90 (17%)
		Bromo_Brdt_II_like	348..449	CDD:99930	24/112 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	454..645
		Nuclear localization signal. /evidence=ECO:0000255	553..557
		BET	639..701	CDD:407211
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..798
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900