DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Crebbp

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_006521814.1	Gene:	Crebbp / 12914	MGIID:	1098280	Length:	2451	Species:	Mus musculus

Alignment Length:	1322	Identity:	248/1322 - (18%)
Similarity:	416/1322 - (31%)	Gaps:	464/1322 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   364 STCDEEADLTAYHKK----KEQNPDYDYVCPNCKSNSSGPGSSQQTIDSIVLSAMDSSSEQLSLK 424
            |...||.|.|....:    :|:.|:........:.|||...:||.|..|.....:....|   |:
Mouse  1031 SQVKEETDTTEQKSEPMEVEEKKPEVKVEAKEEEENSSNDTASQSTSPSQPRKKIFKPEE---LR 1092

  Fly   425 EIELDPLEGKPTMDPSSDELHKLPTGKKKVCLTSVRGRSGKFVLHRMGVMSQINKKRSTRGKGRQ 489
            :..:..||.....||.|     ||                    .|..|..|:
Mouse  1093 QALMPTLEALYRQDPES-----LP--------------------FRQPVDPQL------------ 1120

  Fly   490 LALP----TISSDRCLSRSMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGI---ESDSVMIT 547
            |.:|    .:.:...||       |..:||.....::.:....|:.:|..:..:   ::..|...
Mouse  1121 LGIPDYFDIVKNPMDLS-------TIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKF 1178

  Fly   548 CAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCEGCGKKNDEARLLLCDEC----------DIS 602
            |::..:.:......|..|.|            .|  ||:|.:.:...||  |          |.:
Mouse  1179 CSKLAEVFEQEIDPVMQSLG------------YC--CGRKYEFSPQTLC--CYGKQLCTIPRDAA 1227

  Fly   603 YHIYCVNPPLETVPTGNWKCSFCTLCQKC-----GRNPTEKSEFGDSNMLECPSCTSQSSCPVCK 662
            |:.|..:.|...:....:.     .|:||     |.|.|    .||.        .||....:.|
Mouse  1228 YYSYQNSSPKYGLLADRYH-----FCEKCFTEIQGENVT----LGDD--------PSQPQTTISK 1275

  Fly   663 VSYS-------NGEMIIQCEHCELWAHFHCDSVNAQLTIDHYD---NNVYKCFKCRCSTR----- 712
            ..:.       :.|..:.|:.|....|        |:.:.|||   .:.:.|..|...|.
Mouse  1276 DQFEKKKNDTLDPEPFVDCKECGRKMH--------QICVLHYDIIWPSGFVCDNCLKKTGRPRKE 1332

  Fly   713 ---STNSLADAKFGN--EDSL------AITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDM 766
               |...|...:.||  ||.:      ...|:..:.||.:.|||..:.:.|.|.:..... ||:|
Mouse  1333 NKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFVD-SGEM 1396

  Fly   767 PESAPE------ALHWIDGVCLSESGLGM----------------IKSL-STEIKRKRKMRQALG 808
            .||.|.      |...||||.:...|:.:                |..| |....|.|.:|.|:.
Mouse  1397 SESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFFRPRCLRTAVY 1461

  Fly   809 NGKDGQLEAAAEEALEK--YKDGMVWDGTENAIP--EG--FTISINDEGVNILRKKRQRNLQKLG 867
            :    ::.....|.::|  |..|.:|     |.|  ||  :....:.....|.:.||   ||:
Mouse  1462 H----EILIGYLEYVKKLGYVTGHIW-----ACPPSEGDDYIFHCHPPDQKIPKPKR---LQE-- 1512

  Fly   868 IGGFSVRNRGLKKDSEETTAVDQINSLMTMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEG 932
                     ..||..::..|...||..      |.|.::..:::|..|..:...|..|...:||
Mouse  1513 ---------WYKKMLDKAFAERIINDY------KDIFKQANEDRLTSAKELPYFEGDFWPNVLE- 1561

  Fly   933 GELVMADTDSSDEIDASMKVYFTRPEGKSPANQDTLAVNKSPAKTVKKVKAELKTENKTVFIQQM 997
                    :|..|::...:   .|.:.:|.|..:|...::..:|..||...:...:||:
Mouse  1562 --------ESIKELEQEEE---ERKKEESTAASETPEGSQGDSKNAKKKNNKKTNKNKS------ 1609

  Fly   998 PMGIQNKNGTTP-VSNVFDPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKP 1061
              .|...|...| :.||.:.|..::..|:..::.....:      .|.....:||.|       |
Mouse  1610 --SISRANKKKPSMPNVSNDLSQKLYATMEKHKEVFFVI------HLHAGPVISTQP-------P 1659

  Fly  1062 MRESPAVLV-------DSFMVPNQLPQEQ--KFHNQLYLGGNT---LVNPAQQLQFRQQAPQNAN 1114
            :.:...:|.       |:|:.   |.:::  :|.:......:|   ||....|.|.|.....|..
Mouse  1660 IVDPDPLLSCDLMDGRDAFLT---LARDKHWEFSSLRRSKWSTLCMLVELHTQGQDRFVYTCNEC 1721

  Fly  1115 KQNMQTIMSQVVLQ--------------TEKR-------PEEEQKVVEPVTETLNAGTQKTAEKM 1158
            |.:::|.....|.:              |.|.       .:|.....||        ..|:.::.
Mouse  1722 KHHVETRWHCTVCEDYDLCINCYNTKSHTHKMVKWGLGLDDEGSSQGEP--------QSKSPQES 1778

  Fly  1159 RKDEDLGLMATISAVLY------ANTEHPNLKEL-----------------FPIWNDRCKQILKR 1200
            |:   |.:...|.::::      ||...|:.:::                 .|:    |||::
Mouse  1779 RR---LSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPV----CKQLI-- 1834

  Fly  1201 WRSLC---------NEKKAPFLQKAKDNRSALRQRREQNKI------------------------ 1232
              :||         |:...||....|..   |||::.|:::
Mouse  1835 --ALCCYHAKHCQENKCPVPFCLNIKHK---LRQQQIQHRLQQAQLMRRRMATMNTRNVPQQSLP 1894

  Fly  1233 ----------------PMPPKPQKQEEMGRVWKQP---PKLKEDQPNMFVTYNGNAYDMGNYVGG 1278
                            |..|:|..|.:...|...|   |.:...||...|:           .|.
Mouse  1895 SPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVNMSPAGFPNVARTQPPTIVS-----------AGK 1948

  Fly  1279 SAQAASNNPNPHHVMPNVNDNLVIKATMQ-----RTQVHTTAASTLKMTTVDNRLELNTAVYGT- 1337
            ........|.|....|     ..::|..|     :.|.|      |....::|.:....|..||
Mouse  1949 PTNQVPAPPPPAQPPP-----AAVEAARQIEREAQQQQH------LYRANINNGMPPGRAGMGTP 2002

  Fly  1338 ----EPIGDKKLRNLLQKNSTEPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPM---------- 1388
                .|:|    .|:.:.|.....:|.:          |..|..|..||.|..||
Mouse  2003 GSQMTPVG----LNVPRPNQVSGPVMSS----------MPPGQWQQAPIPQQQPMPGMPRPVMSM 2053

  Fly  1389 ---LSISGKSQPSEGRSLEQDVKLGEPQEATSSAVELENVGFSDLLGGLGEGDDDDLLKSLTSEM 1450
               .:::|...|:          :..|:..:.||::                   |||::|.|.
Mouse  2054 QAQAAVAGPRMPN----------VQPPRSISPSALQ-------------------DLLRTLKSP- 2088

  Fly  1451 GDDFNILEYADPELDVNVLNSL 1472
                     :.|:....|||.|
Mouse  2089 ---------SSPQQQQQVLNIL 2101

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600	7/31 (23%)
		PHD4_KMT2C_like	530..578	CDD:276987	6/50 (12%)
		PHD5_KMT2C_like	580..625	CDD:276988	11/54 (20%)
		PHD6_KMT2C_like	657..707	CDD:276989	10/59 (17%)
		NHP6B	1101..>1237	CDD:227935	34/228 (15%)
		HMG	1173..1231	CDD:197700	17/89 (19%)
Crebbp	XP_006521814.1	zf-TAZ	362..429	CDD:366931
		KIX	586..666	CDD:366953
		PHA03247	<687..1037	CDD:223021	2/5 (40%)
		COG5076	942..>1194	CDD:227408	37/209 (18%)
		Bromo_cbp_like	1088..1195	CDD:99927	24/153 (16%)
		RING_CBP-p300	1207..1289	CDD:276805	18/100 (18%)
		PHD_CBP_p300	1291..1322	CDD:277032	8/38 (21%)
		HAT_KAT11	1353..>1564	CDD:369758	54/249 (22%)
		ZZ_CBP	1716..1756	CDD:239077	6/39 (15%)
		ZnF_TAZ	1777..1855	CDD:214717	15/88 (17%)
		Med15	1971..>2422	CDD:312941	36/190 (19%)
		Creb_binding	2045..2125	CDD:370251	15/96 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900