DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and Brdt

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_006534791.1	Gene:	Brdt / 114642	MGIID:	1891374	Length:	961	Species:	Mus musculus

Alignment Length:	846	Identity:	153/846 - (18%)
Similarity:	283/846 - (33%)	Gaps:	274/846 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   815 LEAAAEEALEKYKDGMVW------DGTENAIPEGFTISINDEGVNILRKKRQRN----------- 862
            |:....:||  :|.|..|      |..:..:|:.:||......:|.::|:.:..
Mouse    34 LQRVVLKAL--WKHGFSWPFQQPVDAVKLKLPDYYTIIKTPMDLNTIKKRLENKYYEKASECIED 96

  Fly   863 -----------------------------LQKLG--------IGGFSVRNRGLKKDSEETTAV-- 888
                                         :|||.        :||    ...:|||.::..||
Mouse    97 FNTMFSNCYLYNKTGDDIVVMAQALEKLFMQKLSQMPQEEQVVGG----KERIKKDIQQKIAVSS 157

  Fly   889 --DQINSLMTMDKKKKIIRKKQKNKL----IEAYPVYL-QEAFFGKPLLEGGELVM--------A 938
              :||.|     |..:.:.|:|:...    |...|:.: |||   .|:.:...||.        |
Mouse   158 AKEQIPS-----KAAENVFKRQEIPSGLPDISLSPLNMAQEA---PPICDSQSLVQITKGVKRRA 214

  Fly   939 DT--------DSSDEIDASMKVYFTRPEGKSPANQDT----LAVNKSPAKTVKKVKAELKTENKT 991
            ||        .:|.|...:::.  |:|. ..|..::|    |..::...|.:|.||...:.::.:
Mouse   215 DTTTPTTSIAKASSESPPTLRE--TKPV-NMPVKENTVKNVLPDSQQQHKVLKTVKVTEQLKHCS 276

  Fly   992 VFIQQM-------------------PMGIQNKNGTTPVSNVFD--PLQAEISN------------ 1023
            ..:::|                   .:|:.|....  |.|..|  .::.::.|
Mouse   277 EILKEMLAKKHLPYAWPFYNPVDADALGLHNYYDV--VKNPMDLGTIKGKMDNQEYKDAYEFAAD 339

  Fly  1024 --TVFAN-------RHPLDALAS-------------PNVPELDMANSVSTVPSAEVIEKPMRESP 1066
              .:|.|       .|.:.|:|.             |:.|...|.....|..||:.:.:. ..|.
Mouse   340 VRLMFMNCYKYNPPDHEVVAMARTLQDVFELHFAKIPDEPIESMHACHLTTNSAQALSRE-SSSE 403

  Fly  1067 AVLVDSFMVPNQLPQEQ---KFHNQLYLGGNTLVNPAQQLQFRQQAP----QNANKQNMQTIMSQ 1124
            |...|:....::..:.|   |...||    |.:   .||||...|.|    :..|:::.:....:
Mouse   404 ASSGDASSEDSEDERVQHLAKLQEQL----NAV---HQQLQVLSQVPLRKLKKKNEKSKRAPKRK 461

  Fly  1125 VVLQTEKRP---------EEEQKVVEPVTE--TLNAGTQKTAEKMRKDEDLGLMATIS------- 1171
            .|...::.|         :|:.|:.:|..:  .|.:..:..|:.|..||...|...|:
Mouse   462 KVNNRDENPRKKPKQMKQKEKAKINQPKKKKPLLKSEEEDNAKPMNYDEKRQLSLDINKLPGDKL 526

  Fly  1172 --AVLYANTEHPNLKELFP-----------------------------IWNDRCKQILKRWRSLC 1205
              .|....:..|:|:...|                             ....:.|::::....|.
Mouse   527 GRIVHIIQSREPSLRNSNPDEIEIDFETLKASTLRELEKYVLACLRKRSLKPQAKKVVRSKEELH 591

  Fly  1206 NEKKAPFLQKAKDNRSALRQRREQNKIP----MPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTYN 1266
            :|||....::..|..:.|..|:.|.|.|    .||.|....      ..||...|......:|.:
Mouse   592 SEKKLELERRLLDVNNQLNCRKRQTKRPAKVEKPPPPPPPP------PPPPPPPELASGSRLTDS 650

  Fly  1267 GNAYDMGNYVGGSAQAASNNPNPHHVMPNVNDNLVIKATMQRTQVHT--TAASTLKMTTVDNRLE 1329
            .::...|:....|:..:|::.:......:.:|:....::....::..  |......:...:|..:
Mouse   651 SSSSGSGSGSSSSSSGSSSSSSSSGSASSSSDSSSSDSSDSEPEIFPKFTGVKQNDLPPKENIKQ 715

  Fly  1330 LNTAVYGTEPIGDKKLRNLLQKNSTEPM-LMGANSDLFLGNDV-MRLGMMQNTPITQNNPM---- 1388
            :.::|   :.|...:..  |.:.||.|. ..|.:|...||..| ..|...:||...|..|:
Mouse   716 IQSSV---QDITSAEAP--LAQQSTAPCGAPGKHSQQMLGCQVTQHLQATENTASVQTQPLSEYV 775

  Fly  1389 --------------LSISGKS----QPSEGRSLEQDVK---------LGEPQEATS---SAVELE 1423
                          :..|.:|    :|......::|:|         ||:|.:|:|   |:.||.
Mouse   776 LLGDCKRVLLGPPVVHTSAESLTVLEPECHAPAQKDIKIKNADSWKSLGKPVKASSVLKSSDELF 840

  Fly  1424 N 1424
            |
Mouse   841 N 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	35/192 (18%)
		HMG	1173..1231	CDD:197700	13/86 (15%)
Brdt	XP_006534791.1	Bromo_Brdt_I_like	26..132	CDD:99929	15/99 (15%)
		Bromo_Brdt_II_like	271..372	CDD:99930	12/102 (12%)
		BET	505..567	CDD:374956	9/61 (15%)
		BRD4_CDT	919..961	CDD:374989
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900