DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and BAZ1A

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_038476.2	Gene:	BAZ1A / 11177	HGNCID:	960	Length:	1556	Species:	Homo sapiens

Alignment Length:	712	Identity:	151/712 - (21%)
Similarity:	244/712 - (34%)	Gaps:	235/712 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   402 SQQTIDSIVLSAMDSSSEQLSLKE----IELDPLEGKPTMDPSSDELHKLPTGKKKVCLTSVRGR 462
            |::..::.::..::...|::.:.|    |..|.|.|..|..||:            |...:...:
Human  1019 SEENKENGIIKTVNEDVEEMEIDEQTKVIVKDRLLGIKTETPST------------VSTNASTPQ 1071

  Fly   463 SGKFVLHRMGV-MSQINKKRSTRG-KGRQLALPTISSDRCLSRSMETDLTSDKKLLLCSARDKFI 525
            |...|:|.:.: :.||.     :| :.|.|..|..:||.  .||.:|.|...::.||.||
Human  1072 SVSSVVHYLAMALFQIE-----QGIERRFLKAPLDASDS--GRSYKTVLDRWRESLLSSA----- 1124

  Fly   526 QAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCEGCGKKNDE 590
            ....:.:...:|    |..:|.                 |:.||.        ..|:.|.||.|.
Human  1125 SLSQVFLHLSTL----DRSVIW-----------------SKSILN--------ARCKICRKKGDA 1160

  Fly   591 ARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQ 655
            ..::|||.||..:|.|||.|.|:|||.|:|   ||..|:     |.::|....|.  :.||..|.
Human  1161 ENMVLCDGCDRGHHTYCVRPKLKTVPEGDW---FCPECR-----PKQRSRRLSSR--QRPSLESD 1215

  Fly   656 SSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKCRCSTRSTNSLADA 720
            ..     |..|.|.     |..|:    ..|....|...:.|:..                 .|.
Human  1216 ED-----VEDSMGG-----EDDEV----DGDEEEGQSEEEEYEVE-----------------QDE 1249

  Fly   721 KFGNEDSLAITPQGSKPFVHITASS----GPSFDSKSGAER--NHPTLSGDMPESAPEALHWIDG 779
            ....|:.....|:..:|.|.:...:    ..||.|:...:.  .:|:.|   .:|.|:.
Human  1250 DDSQEEEEVSLPKRGRPQVRLPVKTRGKLSSSFSSRGQQQEPGRYPSRS---QQSTPKT------ 1305

  Fly   780 VCLSESGLGMIKSLSTEIKRKRKMRQALGNGK--DGQLEAAAEEALEKYKDGMVWDGTENAIPEG 842
            ...|::|..:.|..|......:.:|.|..:.:  .|.|:|
Human  1306 TVSSKTGRSLRKINSAPPTETKSLRIASRSTRHSHGPLQA------------------------- 1345

  Fly   843 FTISINDEGVNILRKKRQRNLQKLGIGGFSVRNRG------------LKKDSEETTAVDQINSLM 895
                  |..|.:|..:|:|..:|      |..|..            ..|.||::.:|:..:.|.
Human  1346 ------DVFVELLSPRRKRRGRK------SANNTPENSPNFPNFRVIATKSSEQSRSVNIASKLS 1398

  Fly   896 TMDKKKKIIRKKQKNKLIEAYPVYLQEAFFGKPLLEGG------------ELVMADTDSSDEIDA 948
            ..:.:.|  |:.:|.:..|..||.|.....|:   :||            |||..| ||...:..
Human  1399 LQESESK--RRCRKRQSPEPSPVTLGRRSSGR---QGGVHELSAFEQLVVELVRHD-DSWPFLKL 1457

  Fly   949 SMKVYFTRPEGKSPANQDTLAVNKSP------AKTVKKVKAELKTENKTVFIQQMPMGIQN---- 1003
            ..|:       :.|...|.:   |.|      .:.|.|.:.:|.:|    ||..:.:...|
Human  1458 VSKI-------QVPDYYDII---KKPIALNIIREKVNKCEYKLASE----FIDDIELMFSNCFEY 1508

  Fly  1004 --------KNGTTPVSNVFDPLQAEISNTVFANRHPLDALASP-NVPELDMANSVSTVPSAE 1056
                    |.||.  ...|..:||:          .|....:| ||      :.|||.|:|:
Human  1509 NPRNTSEAKAGTR--LQAFFHIQAQ----------KLGLHVTPSNV------DQVSTPPAAK 1552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987	6/47 (13%)
		PHD5_KMT2C_like	580..625	CDD:276988	21/44 (48%)
		PHD6_KMT2C_like	657..707	CDD:276989	8/49 (16%)
		NHP6B	1101..>1237	CDD:227935
		HMG	1173..1231	CDD:197700
BAZ1A	NP_038476.2	Required for interaction with NCOR1. /evidence=ECO:0000269\|PubMed:17519354	1..133
		Required for association with the CHRAC1/POLE3 complex	1..128
		WAC_Acf1_DNA_bd	23..122	CDD:313708
		DDT	422..485	CDD:214726
		WHIM1	590..635	CDD:317926
		Neuromodulin_N	<645..788	CDD:331332
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..754
		Interaction with SMARCA5	667..933
		WSD	800..926	CDD:317927
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	841..877
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..966
		PHD_BAZ1A	1150..1195	CDD:277097	23/47 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1202..1376		41/252 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1399..1431		8/36 (22%)
		Bromo_Acf1_like	1423..1535	CDD:99936	28/141 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900