DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and BRD8

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_631938.2	Gene:	BRD8 / 10902	HGNCID:	19874	Length:	1235	Species:	Homo sapiens

Alignment Length:	535	Identity:	113/535 - (21%)
Similarity:	200/535 - (37%)	Gaps:	142/535 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   973 SPAKTVKKVKAEL-KTENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAE--ISNT-VFANRHPLD 1033
            :|..|||:.:.:. :||||.  |.:: :.|:..:....|    :|.:.|  ||.. :.|...|..
Human   475 APEMTVKQERLDFEETENKG--IHEL-VDIREPSAEIKV----EPAEPEPVISGAEIVAGVVPAT 532

  Fly  1034 ALASPNVPELDMANSVSTVPSAEVIEKPMR-----ESPAVLVDSFMVPNQL--PQEQKFHNQLYL 1091
            ::..|.:...|:...:.:..:.|::|..:.     |:|...|.:...|..:  |..
Human   533 SMEPPELRSQDLDEELGSTAAGEIVEADVAIGKGDETPLTNVKTEASPESMLSPSH--------- 588

  Fly  1092 GGNTLVNPAQQLQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKV------VEPVTETLNAG 1150
            |.|.:.:|.:.....:....::.|:...||....:.......|||..|      .||..|....|
Human   589 GSNPIEDPLEAETQHKFEMSDSLKEESGTIFGSQIKDAPGEDEEEDGVSEAASLEEPKEEDQGEG 653

  Fly  1151 --TQKTAEKMRKDEDLGLM---ATISAVLYAN--------------TEHPNLKELFPIWNDRCKQ 1196
              ::...|....:.|.|..   ||:.:...|:              :|.....:...||.   |.
Human   654 YLSEMDNEPPVSESDDGFSIHNATLQSHTLADSIPSSPASSQFSVCSEDQEAIQAQKIWK---KA 715

  Fly  1197 ILKRWRSLCNEKKA-PFLQKAKDN-----RSALRQRREQNKIPMPPKPQKQEEMGRVWKQPPKLK 1255
            |:..||:..|.:.| .|||...|:     .|.:::..:.:.|      :|..|.|.: :...:.:
Human   716 IMLVWRAAANHRYANVFLQPVTDDIAPGYHSIVQRPMDLSTI------KKNIENGLI-RSTAEFQ 773

  Fly  1256 EDQPNMF---VTYNGNAYDMGNYVGGSAQAASNNPNPHHVMPNVNDNLVIKATMQR---TQVHTT 1314
            .|...||   |.||.:.:|:                 :|          :...|||   .|:...
Human   774 RDIMLMFQNAVMYNSSDHDV-----------------YH----------MAVEMQRDVLEQIQQF 811

  Fly  1315 AASTLKMTTVDNRLELNTAVYGTEPIGDKKLRNLLQKNST--------EPMLMGANS---DLFLG 1368
            .|:.|.|.|.::            .|..|.||.   ::||        :.:.||:.:   .||:|
Human   812 LATQLIMQTSES------------GISAKSLRG---RDSTRKQDASEKDSVPMGSPAFLLSLFMG 861

  Fly  1369 NDVMRLGMMQNTPITQNNPMLSISGKSQ-PSEGRSLEQDV------KLGEPQEATSSAVELENVG 1426
            ::.:.|...|:.|   |:..||...:|. .|...||:.||      :..|.:|...|:.|.|.
Human   862 HEWVWLDSEQDHP---NDSELSNDCRSLFSSWDSSLDLDVGNWRETEDPEAEELEESSPEREP-- 921

  Fly  1427 FSDLLGGLGEGDDDD 1441
             |:||  :|:|..::
Human   922 -SELL--VGDGGSEE 933

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135
		PHD1_KMT2C_like	205..250	CDD:276984
		PHD2_KMT2C_like	252..298	CDD:276985
		PHD_SF	337..392	CDD:304600
		PHD4_KMT2C_like	530..578	CDD:276987
		PHD5_KMT2C_like	580..625	CDD:276988
		PHD6_KMT2C_like	657..707	CDD:276989
		NHP6B	1101..>1237	CDD:227935	32/166 (19%)
		HMG	1173..1231	CDD:197700	15/77 (19%)
BRD8	NP_631938.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..205
		termin_org_DnaJ	<302..>681	CDD:274808	45/221 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	551..597		9/54 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	621..672		11/50 (22%)
		Bromo_brd8_like	709..812	CDD:99939	29/139 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	827..848		5/23 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..940		10/36 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	966..999
		Bromo_brd8_like	1105..1208	CDD:99939
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5076
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900