DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lpt and kmt2d

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:XP_009295228.1 Gene:kmt2d / 100536523 ZFINID:ZDB-GENE-060223-2 Length:4967 Species:Danio rerio


Alignment Length:1827 Identity:445/1827 - (24%)
Similarity:689/1827 - (37%) Gaps:634/1827 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 KVCCLCNLGEKSALGQGEILQLKAPAPAEIKDKYPTDR--LREDGSRLLYGPKQAASSSGDCHYE 90
            :.|.||:..|:|..|||| ||...|:         :||  |....|.|     .||.:.     :
Zfish    58 RACALCSCVERSLHGQGE-LQCFGPS---------SDRPSLESSVSTL-----PAAGND-----D 102

  Fly    91 LDKIGQPDVVHPAEFLDE-GFVYVHRMCIMWSLRKSQ-----ISDADGAYFATHFAEFLEQKCNF 149
            |..||..:....|...|: |..:||..|.:||....|     :.:.|.|..:.     :::.|::
Zfish   103 LSSIGFSESTCLASLFDDTGSCWVHHWCAVWSEGVEQTEGEVLINVDKAVVSG-----IQRPCDY 162

  Fly   150 CGRYGASINCKM-NCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSLG 213
            |.|.||:|.|:. .|.:.:|:||:||:|....::...:.|.||:.:...|..: ...|..|.|:|
Zfish   163 CKRMGATIRCRAEGCSRFYHFPCSAASGSFQSMKQLALLCPEHIDKAEEIAGE-EARCAVCDSVG 226

  Fly   214 DLSKLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKCEQCQKTYHA 278
            |||.|:.|:.||.|:|..|:.::..|..||||.|..|..||.|| |...|:|.:.|:.|.|.||.
Zfish   227 DLSGLLYCTGCGQHYHDACLEISATPLQRSGWQCPECKVCQTCR-QPGEDSKMLVCDACDKGYHT 290

  Fly   279 SCLRPVISAIPKYGWKCNRCRVCTDCGSR---TPGGGSSSRWHSHYTICDSCYQQRNKGFSCPIC 340
            .||.|.:.::|...|||.|||||.|||.|   .||   |.:|...||:|:.|  ||.:...|.:|
Zfish   291 FCLLPAMDSVPPDSWKCKRCRVCIDCGMRGLKLPG---SEQWFESYTVCEGC--QRRRTSVCGVC 350

  Fly   341 QKAYR---AASHKEMVKCSWCNKFVHSTC----------------------------------DE 368
            .||..   :..|    .|:.|:::|||.|                                  ||
Zfish   351 SKATEPSVSLQH----HCAICHRWVHSDCASLSGPPEEKCICVLCKEIPDEVSVEAEVSSMQVDE 411

  Fly   369 EADL------------------------------------------------------------- 372
            :.||                                                             
Zfish   412 KTDLEVPVELGTELEVVEIAEVKESIMEEALRPEGTEGSTEANVHTEVSTEQQPLLATVSDVDAK 476

  Fly   373 ---------TAYHKKKEQNPDYDYVCPNCKSNSSGPGS-----SQQTIDSIVLSAMDSSSEQLSL 423
                     |...:..||.|: |...|..|.:...|.|     :|..:....:...|.|.::...
Zfish   477 QKEDETTSETVVAEAVEQKPE-DTQDPPIKDSPDSPVSDTKEEAQSDVAGTNIKRQDESQDKPPQ 540

  Fly   424 KEIELD----PLEGKPTMDPSSD------------------------------------------ 442
            .|.|||    ..:.||...|.|.                                          
Zfish   541 SETELDGTVKSTKAKPPSSPCSQLSQITLPVAEEEEPVAMDLEEMGSQEETINRTPPSPAPHTEM 605

  Fly   443 ----------------------------------------------------------------- 442
                                                                             
Zfish   606 PTASDTDDRMGQSEDEEEEDEQGVEESLDDSLLKDESQCEEDQARKELQEDMKPELVLDETSNLS 670

  Fly   443 -----------------------ELHKLPTGKKK--VCLTSV------------------RGRSG 464
                                   ||..:|.|:.:  ..||..                  ||..|
Zfish   671 HGDESSSGFLGSPAEADSQMLSMELSLVPAGRTRSDSLLTETEDSLPFDPLKPDGEKVKRRGSPG 735

  Fly   465 KFVLHRMGVMSQINKKRSTRGKG--------------RQLA------LPTISSDRCLSR--SMET 507
            :..: :.|..|....||..||.|              :.:|      |.::::|..:|:  ..|.
Zfish   736 RSRM-KQGRGSGFPGKRRPRGGGSGGGGGRGRGRSRLKAMASCIDAFLLSMTADTGISKEEDEEE 799

  Fly   508 DLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKG 572
            |.|....::|.|..|||:..||:||:|||.|...:..::.||||.|||||||...|.::.:|:||
Zfish   800 DDTMQNTVVLFSNTDKFVLQQDMCVVCGSFGQGVEGQLLACAQCAQCYHPYCVNSKITKMMLRKG 864

  Fly   573 WRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCG-RNPT 636
            ||||:|.|||.|||.:|.:||||||:||:|||.||::|||:|||.|.|||.:|..|.:|| .:|.
Zfish   865 WRCLECIVCEVCGKASDPSRLLLCDDCDVSYHTYCLDPPLQTVPKGGWKCKWCVCCMQCGASSPG 929

  Fly   637 EKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNV 701
            ...|: .:|...|..|.|..:||||..::...|:::||:||:.|.|..|:|:..:..::...:..
Zfish   930 FHCEW-QNNYNHCGPCASLVTCPVCHENFMEEELLLQCQHCDRWVHAVCESLYTEDEVEQASDEG 993

  Fly   702 YKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSG-D 765
            :.|..|                       ||...:|.|                  ..|.:|. .
Zfish   994 FACTAC-----------------------TPYVPRPVV------------------ESPMMSAFK 1017

  Fly   766 MPESAPEALHWIDGVCLSESGLGMIKSLS-TEIKRKRKMRQALG------------NGKDGQLEA 817
            :.|..|: .:.::||.|:|:|:.:::|:| :.:.::|:.|..||            :|.:|:..|
Zfish  1018 IKEPEPQ-FYRLEGVWLTETGMSLLRSISMSPLHKRRQRRSRLGTMSIDELKEGDADGDEGKGGA 1081

  Fly   818 AAEEALEKY-------KDGMV--WDGTENAIPEGFT--------ISINDEGVNILRKKRQRNLQK 865
            .|.|...|.       :||..  ..|.|..| ||..        :...|:|     |||:|...:
Zfish  1082 EAMECEPKSEAPGSPDRDGGADRETGPEGGI-EGMADCETLKGGVEETDDG-----KKRKRKPYR 1140

  Fly   866 LGIGGFSVRNR---------------GLKKDSEETTAVDQ---------INSLMTMD---KKKKI 903
            .|||||.||.|               |:.:.....|.:::         :....|.:   ::.|.
Zfish  1141 PGIGGFMVRQRKCHTRMRRSLSASGEGVPEGQAPETKLEEGPHPDIPLDVPEAKTAEGEGEQAKK 1205

  Fly   904 IRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVM---------------------ADTDSSDEID 947
            .|.::|:||.:.:|.|||||||||.||:..:...                     |.|.:|:.::
Zfish  1206 RRGRKKSKLEDMFPTYLQEAFFGKTLLDQSKRAFLAPPTPRHTQGLLRPPLPGLGARTAASESVE 1270

  Fly   948 ASMKVYFTRPEG----------KSPANQDTLAV---------NKSPAKTVKKVKAELKTENKTVF 993
            ::     .||.|          .|.|..|...|         ||..:.........||.::    
Zfish  1271 ST-----ARPSGLPMELKQEGEGSKATGDGAVVGSGATGQLFNKDQSSGAAHGSDMLKNKD---- 1326

  Fly   994 IQQMPMGIQNKN---------GTTPVSNVFDPLQAEISNTVFANRHPLDALASPN---VPELDM- 1045
               :|.|::.::         |.|..|:|...||..|.        |:.. ..||   .|:.:: 
Zfish  1327 ---LPQGLERQDSEQFFRKVLGPTEGSSVSGQLQPSIK--------PVQE-GDPNQSSCPQRNLL 1379

  Fly  1046 --ANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQ 1108
              |:...|:||..            ::|||...:|.|    |.:....||  |.:|.|..:....
Zfish  1380 PGASLSGTLPSTG------------MMDSFSGLSQSP----FFDLRDRGG--LFSPDQDEESPWA 1426

  Fly  1109 APQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAG-----TQKTAEKMRKDEDLGLMA 1168
            .|                 .|...|.      .|.|.|...|     .|::.::..|||:||.::
Zfish  1427 TP-----------------STPATPS------TPPTPTEQEGDGLSYNQRSLQRWEKDEELGNLS 1468

  Fly  1169 TISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALR----QRREQ 1229
            |||.|||||...|:||:.:|.|..|||||:|.||.:....|.|:||||||||:|.|    |::.:
Zfish  1469 TISPVLYANMNFPSLKQDYPDWASRCKQIMKIWRKVSAADKVPYLQKAKDNRAAQRINKAQKQAE 1533

  Fly  1230 NKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTY---NGNAYDMGNYVGGSAQAASNNPNPHH 1291
            :::..|.|           .:|.::|.::||:.:..   :|:       |..|:|.:|.. :|:.
Zfish  1534 SQVCRPIK-----------TEPGRIKGERPNLHLQIPPPSGS-------VSTSSQPSSAE-SPYT 1579

  Fly  1292 VMPNVNDNLVIKATMQRTQVHTTAASTL------KMTTVDNRLELNTAVYGTEPIGDKKLRNLLQ 1350
            :.|:...:    |......:.|..::.|      |:::....|:...:...::|           
Zfish  1580 LAPDSASS----AFFPDGPLKTPCSADLQADPFSKLSSQSPHLQSQPSTPYSQP----------- 1629

  Fly  1351 KNSTEPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPMLSISGKSQPSEGRSLEQ-------DVK 1408
              |:.|:...::.....|..          ..||..|....|.:.||...|..:|       ..:
Zfish  1630 --SSSPLPASSSGHCMPGPQ----------GATQGRPSSFGSLEMQPGATRRAQQVDPFFRPQQQ 1682

  Fly  1409 LGEPQEA 1415
            :.:||||
Zfish  1683 IPKPQEA 1689

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135 24/87 (28%)
PHD1_KMT2C_like 205..250 CDD:276984 20/44 (45%)
PHD2_KMT2C_like 252..298 CDD:276985 19/45 (42%)
PHD_SF 337..392 CDD:304600 21/161 (13%)
PHD4_KMT2C_like 530..578 CDD:276987 25/47 (53%)
PHD5_KMT2C_like 580..625 CDD:276988 30/44 (68%)
PHD6_KMT2C_like 657..707 CDD:276989 14/49 (29%)
NHP6B 1101..>1237 CDD:227935 49/144 (34%)
HMG 1173..1231 CDD:197700 31/61 (51%)
kmt2dXP_009295228.1 PHD_SF 122..205 CDD:304600 24/87 (28%)
PHD1_KMT2C_like 218..263 CDD:276984 20/44 (45%)
PHD_SF 265..310 CDD:304600 19/45 (42%)
PHD 346..391 CDD:214584 11/48 (23%)
PHD_SF 821..871 CDD:304600 26/49 (53%)
PHD5_KMT2C_like 872..918 CDD:276988 30/45 (67%)
PHD5_KMT2D 949..999 CDD:277074 14/49 (29%)
HMG 1473..1528 CDD:197700 30/54 (56%)
Med15 3305..>3717 CDD:255446
PHD_SF 4462..4568 CDD:304600
FYRN 4612..4662 CDD:283589
FYRC 4668..4749 CDD:283590
SET 4828..4949 CDD:214614
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D39671at33208
OrthoFinder 1 1.000 - - FOG0002860
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_102575
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4489
SonicParanoid 1 1.000 - - X2220
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.940

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