Protein Alignment Lpt and kmt2d

DIOPT Version :10

• Sequence 1: NP_611847.2
• Gene: Lpt / 37795
• FlyBaseID: FBgn0263667
• Length: 1482
• Species: Drosophila melanogaster
• Sequence 2: XP_009295228.1
• Gene: kmt2d / 100536523
• ZFINID: ZDB-GENE-060223-2
• Length: 4967
• Species: Danio rerio
• Alignment Length: 1827
• Identity: 445/1827 - (24%)
• Similarity: 689/1827 - (37%)
• Gaps: 634/1827 - (34%)

  Fly    28 KVCCLCNLGEKSALGQGEILQLKAPAPAEIKDKYPTDR--LREDGSRLLYGPKQAASSSGDCHYE 90
            :.|.||:..|:|..|||| ||...|:         :||  |....|.|     .||.:.     :
Zfish    58 RACALCSCVERSLHGQGE-LQCFGPS---------SDRPSLESSVSTL-----PAAGND-----D 102

  Fly    91 LDKIGQPDVVHPAEFLDE-GFVYVHRMCIMWSLRKSQ-----ISDADGAYFATHFAEFLEQKCNF 149
            |..||..:....|...|: |..:||..|.:||....|     :.:.|.|..:.     :::.|::
Zfish   103 LSSIGFSESTCLASLFDDTGSCWVHHWCAVWSEGVEQTEGEVLINVDKAVVSG-----IQRPCDY 162

  Fly   150 CGRYGASINCKM-NCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPVICSDNNVECLSCSSLG 213
            |.|.||:|.|:. .|.:.:|:||:||:|....::...:.|.||:.:...|..: ...|..|.|:|
Zfish   163 CKRMGATIRCRAEGCSRFYHFPCSAASGSFQSMKQLALLCPEHIDKAEEIAGE-EARCAVCDSVG 226

  Fly   214 DLSKLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYVKCEQCQKTYHA 278
            |||.|:.|:.||.|:|..|:.::..|..||||.|..|..||.|| |...|:|.:.|:.|.|.||.
Zfish   227 DLSGLLYCTGCGQHYHDACLEISATPLQRSGWQCPECKVCQTCR-QPGEDSKMLVCDACDKGYHT 290

  Fly   279 SCLRPVISAIPKYGWKCNRCRVCTDCGSR---TPGGGSSSRWHSHYTICDSCYQQRNKGFSCPIC 340
            .||.|.:.::|...|||.|||||.|||.|   .||   |.:|...||:|:.|  ||.:...|.:|
Zfish   291 FCLLPAMDSVPPDSWKCKRCRVCIDCGMRGLKLPG---SEQWFESYTVCEGC--QRRRTSVCGVC 350

  Fly   341 QKAYR---AASHKEMVKCSWCNKFVHSTC----------------------------------DE 368
            .||..   :..|    .|:.|:::|||.|                                  ||
Zfish   351 SKATEPSVSLQH----HCAICHRWVHSDCASLSGPPEEKCICVLCKEIPDEVSVEAEVSSMQVDE 411

  Fly   369 EADL------------------------------------------------------------- 372
            :.||
Zfish   412 KTDLEVPVELGTELEVVEIAEVKESIMEEALRPEGTEGSTEANVHTEVSTEQQPLLATVSDVDAK 476

  Fly   373 ---------TAYHKKKEQNPDYDYVCPNCKSNSSGPGS-----SQQTIDSIVLSAMDSSSEQLSL 423
                     |...:..||.|: |...|..|.:...|.|     :|..:....:...|.|.::...
Zfish   477 QKEDETTSETVVAEAVEQKPE-DTQDPPIKDSPDSPVSDTKEEAQSDVAGTNIKRQDESQDKPPQ 540

  Fly   424 KEIELD----PLEGKPTMDPSSD------------------------------------------ 442
            .|.|||    ..:.||...|.|.
Zfish   541 SETELDGTVKSTKAKPPSSPCSQLSQITLPVAEEEEPVAMDLEEMGSQEETINRTPPSPAPHTEM 605

  Fly   443 ----------------------------------------------------------------- 442
                                                                             
Zfish   606 PTASDTDDRMGQSEDEEEEDEQGVEESLDDSLLKDESQCEEDQARKELQEDMKPELVLDETSNLS 670

  Fly   443 -----------------------ELHKLPTGKKK--VCLTSV------------------RGRSG 464
                                   ||..:|.|:.:  ..||..                  ||..|
Zfish   671 HGDESSSGFLGSPAEADSQMLSMELSLVPAGRTRSDSLLTETEDSLPFDPLKPDGEKVKRRGSPG 735

  Fly   465 KFVLHRMGVMSQINKKRSTRGKG--------------RQLA------LPTISSDRCLSR--SMET 507
            :..: :.|..|....||..||.|              :.:|      |.::::|..:|:  ..|.
Zfish   736 RSRM-KQGRGSGFPGKRRPRGGGSGGGGGRGRGRSRLKAMASCIDAFLLSMTADTGISKEEDEEE 799

  Fly   508 DLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKG 572
            |.|....::|.|..|||:..||:||:|||.|...:..::.||||.|||||||...|.::.:|:||
Zfish   800 DDTMQNTVVLFSNTDKFVLQQDMCVVCGSFGQGVEGQLLACAQCAQCYHPYCVNSKITKMMLRKG 864

  Fly   573 WRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCG-RNPT 636
            ||||:|.|||.|||.:|.:||||||:||:|||.||::|||:|||.|.|||.:|..|.:|| .:|.
Zfish   865 WRCLECIVCEVCGKASDPSRLLLCDDCDVSYHTYCLDPPLQTVPKGGWKCKWCVCCMQCGASSPG 929

  Fly   637 EKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNV 701
            ...|: .:|...|..|.|..:||||..::...|:::||:||:.|.|..|:|:..:..::...:..
Zfish   930 FHCEW-QNNYNHCGPCASLVTCPVCHENFMEEELLLQCQHCDRWVHAVCESLYTEDEVEQASDEG 993

  Fly   702 YKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSG-D 765
            :.|..|                       ||...:|.|                  ..|.:|. .
Zfish   994 FACTAC-----------------------TPYVPRPVV------------------ESPMMSAFK 1017

  Fly   766 MPESAPEALHWIDGVCLSESGLGMIKSLS-TEIKRKRKMRQALG------------NGKDGQLEA 817
            :.|..|: .:.::||.|:|:|:.:::|:| :.:.::|:.|..||            :|.:|:..|
Zfish  1018 IKEPEPQ-FYRLEGVWLTETGMSLLRSISMSPLHKRRQRRSRLGTMSIDELKEGDADGDEGKGGA 1081

  Fly   818 AAEEALEKY-------KDGMV--WDGTENAIPEGFT--------ISINDEGVNILRKKRQRNLQK 865
            .|.|...|.       :||..  ..|.|..| ||..        :...|:|     |||:|...:
Zfish  1082 EAMECEPKSEAPGSPDRDGGADRETGPEGGI-EGMADCETLKGGVEETDDG-----KKRKRKPYR 1140

  Fly   866 LGIGGFSVRNR---------------GLKKDSEETTAVDQ---------INSLMTMD---KKKKI 903
            .|||||.||.|               |:.:.....|.:::         :....|.:   ::.|.
Zfish  1141 PGIGGFMVRQRKCHTRMRRSLSASGEGVPEGQAPETKLEEGPHPDIPLDVPEAKTAEGEGEQAKK 1205

  Fly   904 IRKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVM---------------------ADTDSSDEID 947
            .|.::|:||.:.:|.|||||||||.||:..:...                     |.|.:|:.::
Zfish  1206 RRGRKKSKLEDMFPTYLQEAFFGKTLLDQSKRAFLAPPTPRHTQGLLRPPLPGLGARTAASESVE 1270

  Fly   948 ASMKVYFTRPEG----------KSPANQDTLAV---------NKSPAKTVKKVKAELKTENKTVF 993
            ::     .||.|          .|.|..|...|         ||..:.........||.::
Zfish  1271 ST-----ARPSGLPMELKQEGEGSKATGDGAVVGSGATGQLFNKDQSSGAAHGSDMLKNKD---- 1326

  Fly   994 IQQMPMGIQNKN---------GTTPVSNVFDPLQAEISNTVFANRHPLDALASPN---VPELDM- 1045
               :|.|::.::         |.|..|:|...||..|.        |:.. ..||   .|:.::
Zfish  1327 ---LPQGLERQDSEQFFRKVLGPTEGSSVSGQLQPSIK--------PVQE-GDPNQSSCPQRNLL 1379

  Fly  1046 --ANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGGNTLVNPAQQLQFRQQ 1108
              |:...|:||..            ::|||...:|.|    |.:....||  |.:|.|..:....
Zfish  1380 PGASLSGTLPSTG------------MMDSFSGLSQSP----FFDLRDRGG--LFSPDQDEESPWA 1426

  Fly  1109 APQNANKQNMQTIMSQVVLQTEKRPEEEQKVVEPVTETLNAG-----TQKTAEKMRKDEDLGLMA 1168
            .|                 .|...|.      .|.|.|...|     .|::.::..|||:||.::
Zfish  1427 TP-----------------STPATPS------TPPTPTEQEGDGLSYNQRSLQRWEKDEELGNLS 1468

  Fly  1169 TISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALR----QRREQ 1229
            |||.|||||...|:||:.:|.|..|||||:|.||.:....|.|:||||||||:|.|    |::.:
Zfish  1469 TISPVLYANMNFPSLKQDYPDWASRCKQIMKIWRKVSAADKVPYLQKAKDNRAAQRINKAQKQAE 1533

  Fly  1230 NKIPMPPKPQKQEEMGRVWKQPPKLKEDQPNMFVTY---NGNAYDMGNYVGGSAQAASNNPNPHH 1291
            :::..|.|           .:|.::|.::||:.:..   :|:       |..|:|.:|.. :|:.
Zfish  1534 SQVCRPIK-----------TEPGRIKGERPNLHLQIPPPSGS-------VSTSSQPSSAE-SPYT 1579

  Fly  1292 VMPNVNDNLVIKATMQRTQVHTTAASTL------KMTTVDNRLELNTAVYGTEPIGDKKLRNLLQ 1350
            :.|:...:    |......:.|..::.|      |:::....|:...:...::|
Zfish  1580 LAPDSASS----AFFPDGPLKTPCSADLQADPFSKLSSQSPHLQSQPSTPYSQP----------- 1629

  Fly  1351 KNSTEPMLMGANSDLFLGNDVMRLGMMQNTPITQNNPMLSISGKSQPSEGRSLEQ-------DVK 1408
              |:.|:...::.....|..          ..||..|....|.:.||...|..:|       ..:
Zfish  1630 --SSSPLPASSSGHCMPGPQ----------GATQGRPSSFGSLEMQPGATRRAQQVDPFFRPQQQ 1682

  Fly  1409 LGEPQEA 1415
            :.:||||
Zfish  1683 IPKPQEA 1689

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135	24/87 (28%)
		PHD1_KMT2C_like	205..250	CDD:276984	20/44 (45%)
		PHD2_KMT2C_like	252..298	CDD:276985	19/45 (42%)
		PHD_SF	337..392	CDD:473978	21/161 (13%)
		PHD4_KMT2C_like	530..578	CDD:276987	25/47 (53%)
		PHD5_KMT2C_like	580..625	CDD:276988	30/44 (68%)
		PHD6_KMT2C_like	657..707	CDD:276989	14/49 (29%)
		NHP6B	1101..>1237	CDD:227935	49/144 (34%)
		HMG_KMT2C-like	1157..1223	CDD:438813	36/65 (55%)
kmt2d	XP_009295228.1	PHD_SF	122..205	CDD:473978	24/87 (28%)
		PHD1_KMT2C_like	218..263	CDD:276984	20/44 (45%)
		PHD_SF	265..310	CDD:473978	19/45 (42%)
		PHD	346..391	CDD:214584	11/48 (23%)
		DUF612	<401..>613	CDD:282585	24/212 (11%)
		PHD_SF	821..871	CDD:473978	26/49 (53%)
		PHD5_KMT2C_like	872..918	CDD:276988	30/45 (67%)
		PHD5_KMT2D	949..999	CDD:277074	14/49 (29%)
		HMG-box_KMT2D	1447..1530	CDD:438836	39/82 (48%)
		PHA03247	<1559..1927	CDD:223021	28/166 (17%)
		PHA03247	<1750..2209	CDD:223021
		Med15	2957..>3361	CDD:312941
		Med15	3286..>3690	CDD:312941
		PHD_SF	4462..4568	CDD:473978
		FYRN	4611..4662	CDD:461787
		FYRC	4668..4752	CDD:461788
		SET_KMT2C_2D	4814..4966	CDD:380948