DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and kmt2d

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:XP_017947166.2 Gene:kmt2d / 100494109 XenbaseID:XB-GENE-855725 Length:6132 Species:Xenopus tropicalis


Alignment Length:1926 Identity:469/1926 - (24%)
Similarity:715/1926 - (37%) Gaps:626/1926 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    10 EEKAVADDLPYFPEKFPGKVCCLCNLGEKSALGQGEILQLKAPAPAEIKDKYPTDRLREDGSRLL 74
            ||.:|    |........:.|.|||.||.|..||.|:|:.. |:|              |...|:
 Frog    46 EESSV----PQCISDSKNRSCALCNCGEWSPQGQRELLRFD-PSP--------------DHPVLV 91

  Fly    75 YGPKQAASSSGDCHYELDKIGQPDVVHPAE-------FLDEGFVYVHRMCIMWS-----LRKSQI 127
            .||.|...:|       .:|..|.::..||       |...|..:.|..|..||     :..:.:
 Frog    92 PGPIQVQETS-------TQISDPTLIGFAEGVSSTQLFEPTGHCWAHHWCASWSAGVIHVEGTGL 149

  Fly   128 SDADGAYFATHFAEFLEQKCNFCGRYGASINC-KMNCRQVHHWPCAAAAGCLLILESFTVFCTEH 191
            .:.|.|.::.     :.|||.:|.|.||:|.| ...|.:.:|:|||||:|....:::..:.||||
 Frog   150 INVDKAVYSG-----ISQKCEYCNRMGATIQCHSTGCLRRYHFPCAAASGSFQSMKTLKLLCTEH 209

  Fly   192 LSQVPVICSDNNVECLSCSSLGDLSKLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQIC 256
            |.:  .|..|:: .|:.|...|||..|:.|::||.|:|.||:.:...|..||||.|..|..||.|
 Frog   210 LGE--AIAMDDS-RCVLCDKPGDLIDLLFCTSCGLHYHGTCLEITVSPLKRSGWQCPECKVCQTC 271

  Fly   257 RQQDSNDTKYVKCEQCQKTYHASCLRPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHY 321
            | |...||..:.|:.|.|.||..||:|.|..:|...|||..||||..|||||......|:|:.:|
 Frog   272 R-QPGEDTMMLVCDACDKGYHTFCLKPAIECLPTDSWKCKTCRVCRICGSRTAHMEPGSQWYDNY 335

  Fly   322 TICDSCYQQRNKGFSCPICQKAYRAASHKEMVKCSWCNKFVHST----------CDEEADLTAYH 376
            ::|..|.::||:..:|.:|..|.    .||  ||..|.. ||.|          |...:.||...
 Frog   336 SVCSKCQEKRNRAETCVLCSHAL----PKE--KCPNCIN-VHQTVCAQADYSTPCSANSPLTDKR 393

  Fly   377 KKKEQNPD--YDYVCPNCKSNSSG--------------------PGSSQQTIDSIVLSAMDSSSE 419
            :..::|..  .:.....|::...|                    |.|...:::.||.:..|..|.
 Frog   394 QLLQENGSEISNTELSECEAKPLGMSEMNLDPLQKKVSSETLMEPISDSMSLEDIVTTEEDGPST 458

  Fly   420 Q------------LSLKEIELDPLEGK-PTMDPSSD--------------------------ELH 445
            .            :.|:|....|||.: |.::..||                          |:|
 Frog   459 SDNEAAEAPPIMTVPLREKSPPPLEAELPPLNTMSDACDLLDEAPVLVTVEDEEMETEDTETEIH 523

  Fly   446 KL------------------PT---GKKKVCLTSVRGRSGKF--VLH------------------ 469
            ::                  ||   ...:.|.:.:.|...:|  .:|                  
 Frog   524 EVQKEVTGLALVSSSIKTASPTLVSDTSQACASVIEGSDIRFTDTVHLTSGPCQSPSKTPSCSQQ 588

  Fly   470 -----------------------------------------------RMGVM------------- 474
                                                           |.|::             
 Frog   589 PSLSDSEMTIESEDPPCQPNTEMLNNDNTFCQEHFGDYSVNKDQGPLRPGLIKSDIVNEISNLSQ 653

  Fly   475 ----------------------------------------------------------------- 474
                                                                             
 Frog   654 GDTTGSYHGSDALGSPDPEGGSLSMEMCLHKEDGSLRLCNDSITETDDSLLYDPSGGKLDAEKTR 718

  Fly   475 -------SQINKKRS-----------------TRGKGRQLALPTISSDRCL-----------SRS 504
                   |::.:.||                 :||:||.....|.||...|           ...
 Frog   719 RKSSPGRSRVKQGRSSSFPGRRRPRGGSGSGTSRGRGRSRLKSTASSIETLPVVDVESSPSKEEE 783

  Fly   505 METDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGIL 569
            .|.|.|....::|.|..|||:..||:||:|||.|..|:..::.|:||.|||||||...:.::.:|
 Frog   784 EEEDDTMQNTVVLFSNTDKFVLMQDMCVVCGSFGRGSEGHLLACSQCSQCYHPYCVNSRITKVML 848

  Fly   570 QKGWRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCGR- 633
            .|||||::|.|||.|||..|.:||||||:||||||.||::|||.|||.|.|||.:|..|.:||. 
 Frog   849 LKGWRCVECIVCEVCGKATDPSRLLLCDDCDISYHTYCLDPPLHTVPKGGWKCRWCVSCMQCGAV 913

  Fly   634 NPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYD 698
            .|..:||: .:|...|..|.|..|||||.:.|..|:::|||.|||.|.|..|:::..:..::...
 Frog   914 TPGFRSEW-QNNYTHCAPCASLVSCPVCHLKYLEGDLLIQCRHCERWLHAVCENLFTEEEVEQAA 977

  Fly   699 NNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLS 763
            :..:.|..|:                       |...||.|.|.....|       .:...|..|
 Frog   978 DEGFDCSSCQ-----------------------PFIPKPVVPIVIPESP-------VKLKEPAAS 1012

  Fly   764 GDMPESAPEALHWIDGVCLSESGLGMIKSLS-TEIKRKRKMRQALGNG----------------K 811
                 ||.......|||.|:|:|:.:::||| :.|::|:..|..|..|                |
 Frog  1013 -----SAEPQYFRFDGVWLTEAGMAVLRSLSLSPIQKKKPRRSRLCTGGEVFIDGPDTVGTEERK 1072

  Fly   812 DGQLEAAAEEALEKYKDGMVWDGTENAI--PEGFTISIND--EGVNILR--KKRQRNLQKLGIGG 870
            :|::|....::.....:.|..|....|:  ||....:..:  :|:..:.  ||::|...:.||||
 Frog  1073 EGEVECEDHKSDHCNVEPMECDIKTEAMGSPEREACAETEPVKGMEDVEDVKKKKRKPYRPGIGG 1137

  Fly   871 FSVRNRGLK--------------KDSE--------------------ETTAVDQINSLMTMDKKK 901
            |.:|.|...              ::|:                    |||..:      :.||||
 Frog  1138 FMIRQRKTHTRTKKGHAAFLEAFRESQNQDVHPDDAAPPETPTETGPETTITE------SDDKKK 1196

  Fly   902 KIIRKKQKNKLIEAYPVYLQEAFFGKPLLE-GGELVMADTDSSDE--------------IDASMK 951
            :  |.::|:||.:.:|.|||||||||.|:: |.:.::|....|.:              :..|::
 Frog  1197 R--RGRKKSKLEDMFPAYLQEAFFGKELIDLGKQALLASRPVSHKPKPAQGATLPPQGSVQTSLQ 1259

  Fly   952 VYFTRPEGKSPANQDTLA--VNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVF 1014
              .|.|..: |.|..|.|  |.:|.:..:|..|:|                              
 Frog  1260 --STAPSAE-PVNAPTPAVPVEESDSSEMKAEKSE------------------------------ 1291

  Fly  1015 DPLQAEISNTVFANRHPLDALASPNVPELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQL 1079
            |..:||:.| |.|..| ::...:..:||..:.:.:..:...|:.:....:...:|.|   |....
 Frog  1292 DASEAEVLN-VAAVTH-MEERITVLLPEGALGSDLDKISMEELPKMENTDIQQMLKD---VLGPT 1351

  Fly  1080 PQEQKFHNQLYLGGN--------TLVNPAQQLQ--------FRQQAPQNANKQNMQTIMSQVVLQ 1128
            .||...:|   :||.        |..:|...||        :.:...|:...:|..::.|.....
 Frog  1352 DQEPTLNN---IGGRMDSSTSGATSQSPQTFLQGVSHPTTSYVESFSQSGFLENRNSVFSPEHCD 1413

  Fly  1129 TEKRPEEEQKVVEPVTETLNAG---TQKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIW 1190
            :|...........|..|....|   .|::.::..|||:||.::|||.|||||...||||..:|.|
 Frog  1414 SESSWPTASTPTTPTAEGEADGLSYNQRSLQRWEKDEELGELSTISPVLYANKNFPNLKLEYPDW 1478

  Fly  1191 NDRCKQILKRWRSLCNEKKAPFLQKAKDNRSALR----QRREQNKIPMPPKPQKQEEMGRVWKQP 1251
            ..|||||:|.||.:....|||:||||||||:|.|    ||:.:|:|    ..|.:.|:.|...:|
 Frog  1479 TSRCKQIMKLWRKVPAPDKAPYLQKAKDNRAAHRISKVQRQAENQI----NKQAKVEVARKIDRP 1539

  Fly  1252 PKLKEDQPNMFVTYNGNAYDMGNYVGGSAQAASNNPNPHHVMPNVNDNLVIKATMQRTQVHTTAA 1316
            ....:..|:                  |.....:.|:....:|...|..:             ::
 Frog  1540 VLQLQIPPH------------------SGSQPGSTPDFRTGVPTAQDPFL-------------SS 1573

  Fly  1317 STLKMTTVDNRLELNTA-VYGTEPIGD-----------KKLRNLLQKNSTEPMLMGANSDLFLGN 1369
            .::..|:.|..|:.:.| ..|.|..||           ::..|.....|.:|....:     ||.
 Frog  1574 GSVLSTSSDLFLKPSPAGTPGVESPGDVFFKLPPPSPSQEHMNSSPAYSLDPRYQSS-----LGQ 1633

  Fly  1370 DVMRLGMMQNTPITQNNP------------------------------------------MLSIS 1392
            ..:..|..|....|:|:|                                          .||:.
 Frog  1634 SPVSCGSFQTMSGTENHPGPNAQQATHNLDYQSSHQATTHHQPLTPEPFIKPRYPAGSLDNLSLI 1698

  Fly  1393 GKSQPSEGRSLEQDVKLGEPQEATSS-------------AVELENVGFSDLLGGLGEGDDD---- 1440
            |...|...:|.|...|.|||..:.|.             .|:.|:||.......:|..|..    
 Frog  1699 GSPGPRLSQSSENSSKPGEPMMSPSRYGDPKRHSDGMLYQVKKEDVGSPGYPHSVGSADGTAEMK 1763

  Fly  1441 -DLLKS----LTSEMGDDFNILEYADPELDVNVLNSLDFDD 1476
             |:.|:    .||::........:.||.|...|.:.....|
 Frog  1764 FDVFKAPLTPRTSQIEPHSPASSHRDPHLYAQVTSPQHHSD 1804

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135 26/87 (30%)
PHD1_KMT2C_like 205..250 CDD:276984 19/44 (43%)
PHD2_KMT2C_like 252..298 CDD:276985 20/45 (44%)
PHD_SF 337..392 CDD:304600 15/66 (23%)
PHD4_KMT2C_like 530..578 CDD:276987 23/47 (49%)
PHD5_KMT2C_like 580..625 CDD:276988 31/44 (70%)
PHD6_KMT2C_like 657..707 CDD:276989 17/49 (35%)
NHP6B 1101..>1237 CDD:227935 54/150 (36%)
HMG 1173..1231 CDD:197700 34/61 (56%)
kmt2dXP_017947166.2 ePHD1_KMT2D 126..209 CDD:277165 26/87 (30%)
PHD1_KMT2C_like 220..265 CDD:276984 19/44 (43%)
PHD2_KMT2D 267..312 CDD:277070 20/45 (44%)
PHD3_KMT2D 808..858 CDD:277072 24/49 (49%)
PHD5_KMT2C_like 859..905 CDD:276988 31/45 (69%)
PHD5_KMT2D 936..986 CDD:277074 17/49 (35%)
HMG 1461..1512 CDD:197700 31/50 (62%)
PHA03307 1745..>2115 CDD:223039 12/60 (20%)
PHA03307 1975..>2261 CDD:223039
Med15 3053..>3382 CDD:312941
ePHD2_KMT2D 5627..5733 CDD:277168
FYRN 5776..5818 CDD:399155
FYRC 5833..5917 CDD:399156
SET_KMT2C_2D 5979..6131 CDD:380948
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D39671at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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