DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lpt and kmt2c

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	XP_031760372.1	Gene:	kmt2c / 100486829	XenbaseID:	XB-GENE-485111	Length:	5103	Species:	Xenopus tropicalis

Alignment Length:	1688	Identity:	447/1688 - (26%)
Similarity:	646/1688 - (38%)	Gaps:	541/1688 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KVCCLCNLGEKSALGQGEILQLKAPAP---------AEIKDKYPTDRLREDGSRL--LYGPKQAA 81
            ::|..|..||:|.||||| |:|..|.|         :|..|....|...::..|.  ..||::|.
Frog   134 QLCAFCYCGERSLLGQGE-LKLFRPTPGFPLPWKTHSETTDTESNDETCKNSGRTEKQRGPRKAK 197

  Fly    82 S--SSGDCHY----------------ELDKIGQPDVVH-PAEFLDEGFVYVHRMCIMWS-----L 122
            |  :.|.|..                ||.::|..|..| .|.|...|..:.|..|..||     .
Frog   198 SPQNGGACANASTQTSSDEPAGKFWDELCQVGLLDDFHIQALFEPSGHCWAHLRCAQWSPGVHQN 262

  Fly   123 RKSQISDADGAYFATHFAEFLEQKCNFCGRYGASIN-CKMNCRQVHHWPCAAAAGCLLILESFTV 186
            .:.::...|.|..:..     .::|.:|...||:|. |:..|.|.:|:||||.||....|...|:
Frog   263 EEQELVSVDKAVLSGS-----TERCAYCKHLGATIKCCEETCTQTYHYPCAAGAGTFQDLNCLTL 322

  Fly   187 FCTEHLSQVPVICSDNNVECLSCSSLGDLSKLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCT 251
            .|.||:.|. :..|..:..|..|.|.|||...:.|:|||.|:|..|:.:|..|..|:||.|..|.
Frog   323 LCPEHIDQA-LERSKEDANCALCDSSGDLLDQLFCTTCGQHYHGMCLDIAVTPLKRAGWQCPDCK 386

  Fly   252 KCQICRQQDSNDTKYVKCEQCQKTYHASCLRPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSR 316
            .||.|: ...:|.:.:.|:.|.|.||..||:||:.::|..||||..||:||:||:||     ||.
Frog   387 VCQNCK-HSGDDNQMLVCDTCDKGYHTFCLQPVMDSVPTNGWKCKNCRICTECGTRT-----SSL 445

  Fly   317 WHSHYTICDSCYQQRNKGFSCPICQKAYRAASHKEMVKCSWCNKFVHSTCD-------------- 367
            ||.:..:||.|:||: ....||||.|..:....|:|:.|..|.:::|..|:
Frog   446 WHLNCLLCDPCFQQQ-VSLPCPICDKPLQPELQKDMLHCHVCKRWIHLDCEKCTENDIDDQLKED 509

  Fly   368 ----------EEAD----------------------------LTAYHKKKEQN---PDYDYVC-- 389
                      |||:                            .|...|....|   ||...||
Frog   510 YACTLCKQLAEEAEPGDHCVGMEVTESNNVCTGEMEMDTGRKTTFQDKALNHNNIAPDSTTVCIT 574

  Fly   390 ----------------------------------------------------PNCKSNSSGPGS- 401
                                                                |...|...||.|
Frog   575 EETPLHNEKAKLENDFSHSDDPEEMETSHAEIENPMPEGVKEKAERERHLLLPQSVSRHDGPKSV 639

  Fly   402 -------------SQQTIDSIVLSAMDSSSEQLSLKEIE---------------LDPL------- 431
                         :.:|::....|.|..|..:...|..|               .|||
Frog   640 LPPETEASVKDKTASKTLEVSHKSPMSESKVESCSKMAEHFDSTGGHEGTAQENNDPLVPETPHV 704

  Fly   432 ---EGKPTMD-------PSSDELHKLPTG------------------------------------ 450
               |..||.:       |..|:..|.|.|
Frog   705 GEMEATPTSESLTEAGSPFVDKALKSPAGMDSPVTSVDTSKTSVSSSPAVSIDFHPSHDLYQSQT 769

  Fly   451 ------------------------------KKKVCLTSVRGRSGKFVLH---------------- 469
                                          |:|......|.|.|.:..|
Frog   770 PVTSHSTGNAFPTTFISVTPKIGMGKPAITKRKFSPGRPRSRQGAWSSHNTVSPPSWSPDGSEGW 834

  Fly   470 ----------------RMGVMSQINKKR------STR-GKGR--------QLALPTISSDRCLSR 503
                            ::|..|...|:|      |.| |:||        ....|.|::....|.
Frog   835 DILKSRQLLGNPYWSIKVGRGSGFPKRRPRGSGLSGRGGRGRAKLKAPINNFIFPGITTFDVSSY 899

  Fly   504 SMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGI 568
            ..|.:.:....::|.|..|||...||:||:|||.|..::..::.|:||||||||||..:|.::.|
Frog   900 KEEEETSMHNTVVLFSRSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVI 964

  Fly   569 LQKGWRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKC-G 632
            |:||||||:|||||.|||..|..||||||:||||||.:|::|||:|||.|.|||.:|..|..| .
Frog   965 LRKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTFCLDPPLQTVPKGGWKCKWCVSCTNCKA 1029

  Fly   633 RNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHY 697
            ..|..:.|: .:|..:|..|.|.|:||||..:|...|:|:||..|..|:|..|.::|.:..::..
Frog  1030 ITPGLRCEW-QNNYTQCAPCASLSACPVCCQNYIEEELILQCRQCIRWSHASCQNLNTEAEVELA 1093

  Fly   698 DNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTL 762
            .::.:.|..|                            ||||.......|:.|    |:....|.
Frog  1094 ADSGFDCAAC----------------------------KPFVVSHEVIEPTID----AQIIPKTR 1126

  Fly   763 SGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQAL-------------------- 807
            ..|:.::..:     |||||:||||..::||:..::||::.:..|
Frog  1127 DSDVLKTFTQ-----DGVCLTESGLSQLQSLTITVQRKKRSKPKLKLKIINQNSVAVLQTPPYPQ 1186

  Fly   808 -GNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNIL--RKKRQRNLQKLGIG 869
             .:.:||:::.:.|      .|.|..|...::.||...|..:.:...::  .|||:|...:.|||
Frog  1187 SEHSRDGEMDDSRE------VDLMDCDVKSDSSPEREPIDDDSKSTEVMDGLKKRKRKPYRPGIG 1245

  Fly   870 GFSVRNRG-----------LKKDSE-------------------ETTAVDQINSLMTMDKKKKII 904
            ||.||.|.           .:|||.                   ||...|.|......:|.||..
Frog  1246 GFMVRQRSRTGQGKSRRSLSRKDSSGSVSELLPGKDESWSEQLPETPLEDCIPGSDGTEKIKKRY 1310

  Fly   905 RKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVY-------FTRPEGK-- 960
            ||| ||||.|.:|.||||||||:.||:......|.|::..| |.|..:|       |..|...
Frog  1311 RKK-KNKLEETFPAYLQEAFFGRNLLDTSRQSKASTENLTE-DTSHILYRANVNTSFLDPSSDPM 1373

  Fly   961 -------SPANQDTLAVNKSPAKTVKKVKAELKTENKTVFI---QQMPMGIQNK----------N 1005
                   :|:.|.. ...:.|...:.:|   |.||:....|   ...|.|:..|          |
Frog  1374 LSSAATFTPSKQSE-GSTRDPLADLSEV---LNTEDDIFGILTDDTNPTGMSTKGLDLCTFQVEN 1434

  Fly  1006 GTTP-----VSNVFDPLQAEISNTVFANRHP-----LDALASP----------------NVPEL- 1043
            ..:|     :..:.|...|...::|.....|     ||.:.||                .:|||
Frog  1435 SPSPFAGLDIGTMSDDSSALTQSSVAQTSRPLSEDQLDGILSPELDKMVTDGAILGKMYKIPELE 1499

  Fly  1044 --DMANSVSTVPSAEVIEKPMRESP---------------------------AVLVDSFMVPNQL 1079
              |:.:..:.|.|......|....|                           ..:|:..|.||..
Frog  1500 GKDVEDLFTAVLSPLATHPPSLPQPPPPSAHPHPPHTQLLPLHNQGNGFFPRMPMVNGLMPPNSH 1564

  Fly  1080 PQEQKFHNQLYLGG-----NTLVNPAQQLQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKV 1139
            .|    ||.|..|.     :.|.:| ...:.|::||...:..|.         .....|.:.|.
Frog  1565 LQ----HNPLAPGAGLGTFSPLAHP-PYAESREKAPLFRSMGNE---------PAGSWPTQAQS- 1614

  Fly  1140 VEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSL 1204
            :|...:|: :..|::..|..|:|.||.|||::.|||.|...||||:.||.|..|.|||.|.||..
Frog  1615 LESEGDTM-SNAQRSTLKWEKEEALGEMATVAPVLYTNVNFPNLKDEFPDWATRVKQIAKLWRKA 1678

  Fly  1205 CNEKKAPFLQKAKDNRSALRQRREQNKIPMPP---KPQKQE--EMGRV----WKQPPKLKEDQ 1258
            .::::||::|||:|||:|||    .||:.|..   |.|:.|  |..|:    :|.|.|.:|.:
Frog  1679 SSQERAPYVQKARDNRAALR----INKVQMSNDSLKRQQHEILEHSRIESDLFKDPLKQRESE 1737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135	25/87 (29%)
		PHD1_KMT2C_like	205..250	CDD:276984	19/44 (43%)
		PHD2_KMT2C_like	252..298	CDD:276985	18/45 (40%)
		PHD_SF	337..392	CDD:304600	22/163 (13%)
		PHD4_KMT2C_like	530..578	CDD:276987	26/47 (55%)
		PHD5_KMT2C_like	580..625	CDD:276988	30/44 (68%)
		PHD6_KMT2C_like	657..707	CDD:276989	15/49 (31%)
		NHP6B	1101..>1237	CDD:227935	49/138 (36%)
		HMG	1173..1231	CDD:197700	29/57 (51%)
kmt2c	XP_031760372.1	PHD_SF	244..327	CDD:419867	25/87 (29%)
		PHD1_KMT2C_like	340..385	CDD:276984	19/44 (43%)
		PHD2_KMT2C	387..432	CDD:277069	18/45 (40%)
		PHD3_KMT2C	464..515	CDD:276986	11/50 (22%)
		PHD4_KMT2C	919..975	CDD:277071	30/55 (55%)
		PHD5_KMT2C_like	976..1022	CDD:276988	30/45 (67%)
		PHD_SF	1053..1103	CDD:419867	15/49 (31%)
		HMG	1645..1698	CDD:197700	27/52 (52%)
		PHA03247	<2019..2550	CDD:223021
		Myosin_tail_1	<3363..>3450	CDD:396244
		PHD_SF	4594..4698	CDD:419867
		FYRN	4743..4794	CDD:399155
		FYRC	4801..4884	CDD:399156
		SET_KMT2C_2D	4950..5102	CDD:380948
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	83	1.000	Domainoid score	I8231
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D39671at33208
OrthoFinder	1	1.000	-	-		FOG0002860
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010