DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Lpt and kmt2c

DIOPT Version :10

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:XP_031760372.1 Gene:kmt2c / 100486829 XenbaseID:XB-GENE-485111 Length:5103 Species:Xenopus tropicalis


Alignment Length:1688 Identity:447/1688 - (26%)
Similarity:646/1688 - (38%) Gaps:541/1688 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 KVCCLCNLGEKSALGQGEILQLKAPAP---------AEIKDKYPTDRLREDGSRL--LYGPKQAA 81
            ::|..|..||:|.||||| |:|..|.|         :|..|....|...::..|.  ..||::|.
 Frog   134 QLCAFCYCGERSLLGQGE-LKLFRPTPGFPLPWKTHSETTDTESNDETCKNSGRTEKQRGPRKAK 197

  Fly    82 S--SSGDCHY----------------ELDKIGQPDVVH-PAEFLDEGFVYVHRMCIMWS-----L 122
            |  :.|.|..                ||.::|..|..| .|.|...|..:.|..|..||     .
 Frog   198 SPQNGGACANASTQTSSDEPAGKFWDELCQVGLLDDFHIQALFEPSGHCWAHLRCAQWSPGVHQN 262

  Fly   123 RKSQISDADGAYFATHFAEFLEQKCNFCGRYGASIN-CKMNCRQVHHWPCAAAAGCLLILESFTV 186
            .:.::...|.|..:..     .::|.:|...||:|. |:..|.|.:|:||||.||....|...|:
 Frog   263 EEQELVSVDKAVLSGS-----TERCAYCKHLGATIKCCEETCTQTYHYPCAAGAGTFQDLNCLTL 322

  Fly   187 FCTEHLSQVPVICSDNNVECLSCSSLGDLSKLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCT 251
            .|.||:.|. :..|..:..|..|.|.|||...:.|:|||.|:|..|:.:|..|..|:||.|..|.
 Frog   323 LCPEHIDQA-LERSKEDANCALCDSSGDLLDQLFCTTCGQHYHGMCLDIAVTPLKRAGWQCPDCK 386

  Fly   252 KCQICRQQDSNDTKYVKCEQCQKTYHASCLRPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSR 316
            .||.|: ...:|.:.:.|:.|.|.||..||:||:.::|..||||..||:||:||:||     ||.
 Frog   387 VCQNCK-HSGDDNQMLVCDTCDKGYHTFCLQPVMDSVPTNGWKCKNCRICTECGTRT-----SSL 445

  Fly   317 WHSHYTICDSCYQQRNKGFSCPICQKAYRAASHKEMVKCSWCNKFVHSTCD-------------- 367
            ||.:..:||.|:||: ....||||.|..:....|:|:.|..|.:::|..|:              
 Frog   446 WHLNCLLCDPCFQQQ-VSLPCPICDKPLQPELQKDMLHCHVCKRWIHLDCEKCTENDIDDQLKED 509

  Fly   368 ----------EEAD----------------------------LTAYHKKKEQN---PDYDYVC-- 389
                      |||:                            .|...|....|   ||...||  
 Frog   510 YACTLCKQLAEEAEPGDHCVGMEVTESNNVCTGEMEMDTGRKTTFQDKALNHNNIAPDSTTVCIT 574

  Fly   390 ----------------------------------------------------PNCKSNSSGPGS- 401
                                                                |...|...||.| 
 Frog   575 EETPLHNEKAKLENDFSHSDDPEEMETSHAEIENPMPEGVKEKAERERHLLLPQSVSRHDGPKSV 639

  Fly   402 -------------SQQTIDSIVLSAMDSSSEQLSLKEIE---------------LDPL------- 431
                         :.:|::....|.|..|..:...|..|               .|||       
 Frog   640 LPPETEASVKDKTASKTLEVSHKSPMSESKVESCSKMAEHFDSTGGHEGTAQENNDPLVPETPHV 704

  Fly   432 ---EGKPTMD-------PSSDELHKLPTG------------------------------------ 450
               |..||.:       |..|:..|.|.|                                    
 Frog   705 GEMEATPTSESLTEAGSPFVDKALKSPAGMDSPVTSVDTSKTSVSSSPAVSIDFHPSHDLYQSQT 769

  Fly   451 ------------------------------KKKVCLTSVRGRSGKFVLH---------------- 469
                                          |:|......|.|.|.:..|                
 Frog   770 PVTSHSTGNAFPTTFISVTPKIGMGKPAITKRKFSPGRPRSRQGAWSSHNTVSPPSWSPDGSEGW 834

  Fly   470 ----------------RMGVMSQINKKR------STR-GKGR--------QLALPTISSDRCLSR 503
                            ::|..|...|:|      |.| |:||        ....|.|::....|.
 Frog   835 DILKSRQLLGNPYWSIKVGRGSGFPKRRPRGSGLSGRGGRGRAKLKAPINNFIFPGITTFDVSSY 899

  Fly   504 SMETDLTSDKKLLLCSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGI 568
            ..|.:.:....::|.|..|||...||:||:|||.|..::..::.|:||||||||||..:|.::.|
 Frog   900 KEEEETSMHNTVVLFSRSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHPYCVSIKITKVI 964

  Fly   569 LQKGWRCLDCTVCEGCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKC-G 632
            |:||||||:|||||.|||..|..||||||:||||||.:|::|||:|||.|.|||.:|..|..| .
 Frog   965 LRKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTFCLDPPLQTVPKGGWKCKWCVSCTNCKA 1029

  Fly   633 RNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHY 697
            ..|..:.|: .:|..:|..|.|.|:||||..:|...|:|:||..|..|:|..|.::|.:..::..
 Frog  1030 ITPGLRCEW-QNNYTQCAPCASLSACPVCCQNYIEEELILQCRQCIRWSHASCQNLNTEAEVELA 1093

  Fly   698 DNNVYKCFKCRCSTRSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTL 762
            .::.:.|..|                            ||||.......|:.|    |:....|.
 Frog  1094 ADSGFDCAAC----------------------------KPFVVSHEVIEPTID----AQIIPKTR 1126

  Fly   763 SGDMPESAPEALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQAL-------------------- 807
            ..|:.::..:     |||||:||||..::||:..::||::.:..|                    
 Frog  1127 DSDVLKTFTQ-----DGVCLTESGLSQLQSLTITVQRKKRSKPKLKLKIINQNSVAVLQTPPYPQ 1186

  Fly   808 -GNGKDGQLEAAAEEALEKYKDGMVWDGTENAIPEGFTISINDEGVNIL--RKKRQRNLQKLGIG 869
             .:.:||:::.:.|      .|.|..|...::.||...|..:.:...::  .|||:|...:.|||
 Frog  1187 SEHSRDGEMDDSRE------VDLMDCDVKSDSSPEREPIDDDSKSTEVMDGLKKRKRKPYRPGIG 1245

  Fly   870 GFSVRNRG-----------LKKDSE-------------------ETTAVDQINSLMTMDKKKKII 904
            ||.||.|.           .:|||.                   ||...|.|......:|.||..
 Frog  1246 GFMVRQRSRTGQGKSRRSLSRKDSSGSVSELLPGKDESWSEQLPETPLEDCIPGSDGTEKIKKRY 1310

  Fly   905 RKKQKNKLIEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVY-------FTRPEGK-- 960
            ||| ||||.|.:|.||||||||:.||:......|.|::..| |.|..:|       |..|...  
 Frog  1311 RKK-KNKLEETFPAYLQEAFFGRNLLDTSRQSKASTENLTE-DTSHILYRANVNTSFLDPSSDPM 1373

  Fly   961 -------SPANQDTLAVNKSPAKTVKKVKAELKTENKTVFI---QQMPMGIQNK----------N 1005
                   :|:.|.. ...:.|...:.:|   |.||:....|   ...|.|:..|          |
 Frog  1374 LSSAATFTPSKQSE-GSTRDPLADLSEV---LNTEDDIFGILTDDTNPTGMSTKGLDLCTFQVEN 1434

  Fly  1006 GTTP-----VSNVFDPLQAEISNTVFANRHP-----LDALASP----------------NVPEL- 1043
            ..:|     :..:.|...|...::|.....|     ||.:.||                .:||| 
 Frog  1435 SPSPFAGLDIGTMSDDSSALTQSSVAQTSRPLSEDQLDGILSPELDKMVTDGAILGKMYKIPELE 1499

  Fly  1044 --DMANSVSTVPSAEVIEKPMRESP---------------------------AVLVDSFMVPNQL 1079
              |:.:..:.|.|......|....|                           ..:|:..|.||..
 Frog  1500 GKDVEDLFTAVLSPLATHPPSLPQPPPPSAHPHPPHTQLLPLHNQGNGFFPRMPMVNGLMPPNSH 1564

  Fly  1080 PQEQKFHNQLYLGG-----NTLVNPAQQLQFRQQAPQNANKQNMQTIMSQVVLQTEKRPEEEQKV 1139
            .|    ||.|..|.     :.|.:| ...:.|::||...:..|.         .....|.:.|. 
 Frog  1565 LQ----HNPLAPGAGLGTFSPLAHP-PYAESREKAPLFRSMGNE---------PAGSWPTQAQS- 1614

  Fly  1140 VEPVTETLNAGTQKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWNDRCKQILKRWRSL 1204
            :|...:|: :..|::..|..|:|.||.|||::.|||.|...||||:.||.|..|.|||.|.||..
 Frog  1615 LESEGDTM-SNAQRSTLKWEKEEALGEMATVAPVLYTNVNFPNLKDEFPDWATRVKQIAKLWRKA 1678

  Fly  1205 CNEKKAPFLQKAKDNRSALRQRREQNKIPMPP---KPQKQE--EMGRV----WKQPPKLKEDQ 1258
            .::::||::|||:|||:|||    .||:.|..   |.|:.|  |..|:    :|.|.|.:|.:
 Frog  1679 SSQERAPYVQKARDNRAALR----INKVQMSNDSLKRQQHEILEHSRIESDLFKDPLKQRESE 1737

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135 25/87 (29%)
PHD1_KMT2C_like 205..250 CDD:276984 19/44 (43%)
PHD2_KMT2C_like 252..298 CDD:276985 18/45 (40%)
PHD_SF 337..392 CDD:473978 22/163 (13%)
PHD4_KMT2C_like 530..578 CDD:276987 26/47 (55%)
PHD5_KMT2C_like 580..625 CDD:276988 30/44 (68%)
PHD6_KMT2C_like 657..707 CDD:276989 15/49 (31%)
NHP6B 1101..>1237 CDD:227935 49/138 (36%)
HMG_KMT2C-like 1157..1223 CDD:438813 34/65 (52%)
kmt2cXP_031760372.1 PHD_SF 244..327 CDD:473978 25/87 (29%)
PHD1_KMT2C_like 340..385 CDD:276984 19/44 (43%)
PHD2_KMT2C 387..432 CDD:277069 18/45 (40%)
PHD3_KMT2C 464..515 CDD:276986 11/50 (22%)
PHD4_KMT2C 919..975 CDD:277071 30/55 (55%)
PHD5_KMT2C_like 976..1022 CDD:276988 30/45 (67%)
PHD_SF 1053..1103 CDD:473978 15/49 (31%)
HMG-box_KMT2C 1626..1706 CDD:438835 41/83 (49%)
PHA03247 <2019..2550 CDD:223021
Myosin_tail_1 <3363..>3450 CDD:460256
PHD_SF 4594..4698 CDD:473978
FYRN 4743..4794 CDD:461787
FYRC 4801..4884 CDD:461788
SET_KMT2C_2D 4950..5102 CDD:380948
Blue background indicates that the domain is not in the aligned region.

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