DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and Kmt2d

DIOPT Version :9

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:XP_017450810.1 Gene:Kmt2d / 100362634 RGDID:2324324 Length:5544 Species:Rattus norvegicus


Alignment Length:2165 Identity:420/2165 - (19%)
Similarity:628/2165 - (29%) Gaps:1081/2165 - (49%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 PGKVCCLCNLGEKSALGQGEILQLKAPAPAEIKDKYPTDRLREDGSRLLYGPKQAASSSGDC--- 87
            |.:.|.|||.||.|..||.|:.:.:.|:      .:|...:...|           .|||.|   
  Rat    62 PARRCALCNCGEPSLHGQRELQRFELPS------DWPGFPVVSSG-----------GSSGPCEAV 109

  Fly    88 --HYELDKIGQPDVVHPAEFLDE--GFVYVHRMCIMWSL-----RKSQISDADGAYFATHFAEFL 143
              :.:|.:||.|:.:.||. |.|  |..:.|..|..||.     ...::...|.|.|:.     :
  Rat   110 LPNEDLSQIGFPEGLTPAH-LGEPGGHCWAHHWCAAWSAGVWGQEGPELCGVDKAVFSG-----I 168

  Fly   144 EQKCNFCGRYGASINCKM-NCRQVHHWPCAAAAGCLLILESFTVFCTEHLSQVPVICSD-----N 202
            .|:|:.|.|:|||:.|:. .|.:::|:|||.|:|..|.:.:..:.|.||        ||     .
  Rat   169 SQRCSHCARFGASVPCRSPGCSRLYHFPCATASGSFLSMRTLQLLCPEH--------SDGAAHLE 225

  Fly   203 NVECLSCSSLGDLSKLIMCSTCGDHFHSTCIGLANLPDTRSGWNCARCTKCQICRQQDSNDTKYV 267
            ...|..|...|:|..|..|::||.|:|..|:..|.....|:||.|..|..||.|| :..||:|.:
  Rat   226 EAHCAVCEGPGELCDLFFCTSCGHHYHGACLDTALTARKRAGWQCPECKVCQACR-KPGNDSKML 289

  Fly   268 KCEQCQKTYHASCLRPVISAIPKYGWKCNRCRVCTDCGSRTPGGGSSSRWHSHYTICDSCYQQRN 332
            .||.|.|.||..||:|.|..:|.:.|||..||:|..||:.:.....:|.|..:|::|..|::.:.
  Rat   290 VCETCDKGYHTFCLKPPIEDLPAHSWKCKTCRICRACGAGSADLNPNSEWFENYSLCHRCHKVQG 354

  Fly   333 KGFSCPICQKAYRAASHKEM---------------------VKCSWCNKFVHST----------- 365
               |.|:...   |..|..:                     |.|....|..|.|           
  Rat   355 ---SQPVISV---AEQHPAVCSRFSPPEPGETPTEEPSALYVTCQGQPKGTHVTSVQPKEPGPLQ 413

  Fly   366 CD--------------------------------------------------------------- 367
            |:                                                               
  Rat   414 CEAKPLGREGTQLEAQLEAPLNEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPTEESPLSP 478

  Fly   368 ----------------------------------------------------------------- 367
                                                                             
  Rat   479 PPESSPFSPLEESPPSPALDTPLSPPPEASPLSPPFEESPLSPPPEELPSSPPPEASRLSPPPEE 543

  Fly   368 ----------------------------------------------------------------- 367
                                                                             
  Rat   544 SPMSPPPEESPMSPPPEASRLFPPFEESPLSPPPEDSPLSPPPEASRLSPPPEDSPMSPPPEDSP 608

  Fly   368 ----------------------------------------------------------------- 367
                                                                             
  Rat   609 MSPPPEVSRFSPLPVLSHLSPLPEVSRLSPPPEESPLSPPPEDSPTSPPPEASRLSPPPEDSPAS 673

  Fly   368 ---EEADLTAYHKKKEQN-----------------------------PDYDYVCPN------CKS 394
               |.:.|:..|::...:                             |:..|:.|.      |..
  Rat   674 PPPEASQLSPPHEESPASPPPEDSLMSLPMEESPLSPLPEELRLCPQPEEPYLSPQPEEPRLCLQ 738

  Fly   395 NSSGPGS--SQQTIDSIVLS--AMDSSSEQLSL-------------KEIELDPLE---------- 432
            ....|.|  |::...|.||:  .:.|..|:|.|             |::.|.|..          
  Rat   739 PEELPLSPQSEEPCLSPVLAEPCLSSQPEELRLSPVPQEPHLSPQPKQLHLSPQSEEPCLSPMPE 803

  Fly   433 --------------------------------------------------------GKPTMDPSS 441
                                                                    |:|.:.|..
  Rat   804 EPCLYSQPEELHRSPQPQEPPEEPSQCPAPKELSLFPPSREPPLSPMLREPALSEPGEPPLSPLP 868

  Fly   442 DEL-------------------------------------------------------------- 444
            :||                                                              
  Rat   869 EELPLSLSGEPVLSPQLMPPDPLPPPLSPIIPAAAPPALSPLGELEYPFGAKGDSDPESPLAAPI 933

  Fly   445 ----------------------------------------------------HKL--PTGKKKVC 455
                                                                |.|  ||.....|
  Rat   934 LETPISPPPEANCTDPEPVPPMILPPSPGSPMGPASPILMGPLPPPCSPLLQHSLPPPTPPPSHC 998

  Fly   456 ------------LTSVR---GRSGKFVLHRM---------------------------------- 471
                        |:.|:   |.||:..||.|                                  
  Rat   999 SPPALPLSVPSPLSPVQKEVGVSGEAGLHEMETEKGPEPECPALEPRATSPLPSPMGDLSCPAPS 1063

  Fly   472 ----------------------------------------------------------------- 471
                                                                             
  Rat  1064 PAPALDDFSGLGEDTTPLDGTDADPLQSQTGQNSGSLASELKGSPVLLDPEELIPVTPMEVYGPE 1128

  Fly   472 ----------------------------------------------------------------- 471
                                                                             
  Rat  1129 CKQAEQGSPCEEQEEPGAPMAPMPPTLIKSDIVNEISNLSQGDASASFPGSEPLLGSPDPEGAGS 1193

  Fly   472 -----GVMSQIN----------------------------------------KKRST-------- 483
                 ||.:.::                                        ::||:        
  Rat  1194 LSMELGVSTDVSPARDEGSLRLCTDSLPETDDSLLCDTGTATSGGKAEGDKGRRRSSPARSRIKQ 1258

  Fly   484 --------------------RGKGR-----------QLALPTISSDRCLSRSMETDLTSDKKLLL 517
                                ||:||           .|.:..|.|........|.|.|....::|
  Rat  1259 GRSSSFPGRRRPRGGAAHGGRGRGRARLKSTTSSIETLVVADIDSSPSKEEEEEDDDTMQNTVVL 1323

  Fly   518 CSARDKFIQAQDICVMCGSLGIESDSVMITCAQCGQCYHPYCAGVKPSRGILQKGWRCLDCTVCE 582
            .|..|||:..||:||:|||.|..::..::.|:||.|||||||...|.::.:|.|||||::|.|||
  Rat  1324 FSNTDKFVLMQDMCVVCGSFGRGAEGHLLACSQCSQCYHPYCVNSKITKVMLLKGWRCVECIVCE 1388

  Fly   583 GCGKKNDEARLLLCDECDISYHIYCVNPPLETVPTGNWKCSFCTLCQKCG-RNPTEKSEFGDSNM 646
            .||:.:|.:||||||:||||||.||::|||.|||.|.|||.:|..|.:|| .:|....|:.:| .
  Rat  1389 VCGQASDPSRLLLCDDCDISYHTYCLDPPLLTVPKGGWKCKWCVSCMQCGAASPGFHCEWQNS-Y 1452

  Fly   647 LECPSCTSQSSCPVCKVSYSNGEMIIQCEHCELWAHFHCDSVNAQLTIDHYDNNVYKCFKCRCST 711
            ..|..|.|..:||:|...|...:::|||.|||.|.|..|:|:..:..::...:..:.|..|:   
  Rat  1453 THCGPCASLVTCPICHAPYVEEDLLIQCRHCERWMHAGCESLFTEDEVEQAADEGFDCVSCQ--- 1514

  Fly   712 RSTNSLADAKFGNEDSLAITPQGSKPFVHITASSGPSFDSKSGAERNHPTLSGDMP----ESAPE 772
                                |...||.|.:..                |.|   :|    |..|:
  Rat  1515 --------------------PYVVKPVVPVAP----------------PEL---VPVKVKEPEPQ 1540

  Fly   773 ALHWIDGVCLSESGLGMIKSLSTEIKRKRKMRQ------------------ALG--NGKDGQLEA 817
            ...: :||.|:|:|:.::::|:.....||:.|:                  |||  :.|||.|:.
  Rat  1541 FFRF-EGVWLTETGMAVLRNLTMSPLHKRRQRRGRLGLPGEAGLEGSEPSDALGPDDKKDGDLDT 1604

  Fly   818 AAEEALEKYKDGMVWDGTENAIPEGFTISINDEG-----VNILR------KKRQRNLQKLGIGGF 871
               |.|.|.:.|:          |.....|..||     |.:.:      |||:|...:.|||||
  Rat  1605 ---EELLKGEGGV----------EQMECEIKLEGPASPDVELGKEETEESKKRKRKPYRPGIGGF 1656

  Fly   872 SVR--------NRGLKKDSEETTAVDQINSLMTMD----------------KKKKIIRKKQKNKL 912
            .:|        .||....:|.::...|.:.:|..|                |||:..|.::|:||
  Rat  1657 MIRQRKSHTRVKRGPAAQAEGSSGDGQPDEVMPADLPAEGSVEQSLAEGDEKKKQQRRGRRKSKL 1721

  Fly   913 IEAYPVYLQEAFFGKPLLEGGELVMADTDSSDEIDASMKVYF-------------TRPEGKSPAN 964
            .:.:|.|||||||||.||                |.|.|..|             ::|.|...::
  Rat  1722 EDMFPAYLQEAFFGKELL----------------DLSRKALFAVGVGRPGFGLGTSKPRGDGGSD 1770

  Fly   965 QDTLAVNKSPAKTVKKVKAELKTENKTVFIQQMPMGIQNKNGTTPVSNVFDPLQAEISNTVFANR 1029
            :..|            |.|..|.::......:...|   ..||..|:.:.|       ..|.|:.
  Rat  1771 RKEL------------VTALHKGDDGPDVADEESHG---PEGTADVAGLED-------GAVKASP 1813

  Fly  1030 HPLDALASPNVP-ELDMANSVSTVPSAEVIEKPMRESPAVLVDSFMVPNQLPQEQKFHNQLYLGG 1093
            .|.|. ..|..| |..:::.:..:|:.|:   |..||..:   ..:..:.|..|::.|    ||.
  Rat  1814 VPSDP-EKPGTPGEGVLSSDLDRIPTEEL---PKMESKDL---QQLFKDVLGSEREQH----LGC 1867

  Fly  1094 NT--LVNPAQQLQ--FRQ------QAPQNANKQNMQTIMSQVVLQTEKR-----PEEEQ------ 1137
            .|  |......||  |.|      ..|.::...:...:.....|.:.:|     ||..:      
  Rat  1868 GTPGLEGSRTPLQRPFLQGGLALGSLPSSSPMDSYPGLCQSPFLDSRERGGFFSPEPGEPDSPWT 1932

  Fly  1138 --------KVVEPVTETLNAG---TQKTAEKMRKDEDLGLMATISAVLYANTEHPNLKELFPIWN 1191
                    ....|.||....|   .|::.::..|||:||.::|||.|||||...||||:.:|.|:
  Rat  1933 GSGGTTPSTPTTPTTEGEGDGLSYNQRSLQRWEKDEELGQLSTISPVLYANINFPNLKQDYPDWS 1997

  Fly  1192 DRCKQILKRWRSLCNEKKAPFLQKAKDNRSALR----QRREQNKIPMPPKPQKQEEMG------- 1245
            .|||||:|.||.:....|||:||||||||:|.|    |::.:::|      .||.:||       
  Rat  1998 SRCKQIMKLWRKVPAADKAPYLQKAKDNRAAHRINKVQKQAESQI------SKQAKMGDVARKTE 2056

  Fly  1246 ------RVWKQPPKLKEDQP 1259
                  |:..||..|....|
  Rat  2057 RPALHLRIPSQPGALGSPPP 2076

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135 25/87 (29%)
PHD1_KMT2C_like 205..250 CDD:276984 16/44 (36%)
PHD2_KMT2C_like 252..298 CDD:276985 21/45 (47%)
PHD_SF 337..392 CDD:304600 15/382 (4%)
PHD4_KMT2C_like 530..578 CDD:276987 23/47 (49%)
PHD5_KMT2C_like 580..625 CDD:276988 30/44 (68%)
PHD6_KMT2C_like 657..707 CDD:276989 15/49 (31%)
NHP6B 1101..>1237 CDD:227935 56/169 (33%)
HMG 1173..1231 CDD:197700 33/61 (54%)
Kmt2dXP_017450810.1 ePHD1_KMT2D 134..217 CDD:277165 25/87 (29%)
PHD1_KMT2C_like 228..273 CDD:276984 16/44 (36%)
PHD_SF 275..320 CDD:304600 21/45 (47%)
PHD3_KMT2D 1335..1385 CDD:277072 24/49 (49%)
PHD5_KMT2C_like 1386..1432 CDD:276988 30/45 (67%)
PHD5_KMT2D 1463..1513 CDD:277074 15/49 (31%)
HMG 1979..2030 CDD:197700 31/50 (62%)
ePHD2_KMT2D 5039..5145 CDD:277168
FYRN 5189..5239 CDD:283589
FYRC 5247..5334 CDD:197781
SET 5404..5526 CDD:214614
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D39671at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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