DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lpt and nsd2

DIOPT Version :9

Sequence 1:	NP_611847.2	Gene:	Lpt / 37795	FlyBaseID:	FBgn0263667	Length:	1482	Species:	Drosophila melanogaster
Sequence 2:	NP_001076020.1	Gene:	nsd2 / 100000709	ZFINID:	ZDB-GENE-030131-2581	Length:	1461	Species:	Danio rerio

Alignment Length:	866	Identity:	167/866 - (19%)
Similarity:	261/866 - (30%)	Gaps:	360/866 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PAPAEIKDKYPTDRLREDGSRLLYGPKQAASSSGDCHYELDKIGQP----DVVHPAEFLDE--GF 110
            |.|   |.|....|..|.|.:.....|:...||   :.|.::...|    |..||::..:.  |
Zfish   698 PPP---KAKRGRKRKEESGRQSFPASKKCRPSS---YAEPERPDSPSDSTDESHPSKKAERTPG- 755

  Fly   111 VYVHRMCIMWSLRKSQISDADGAYFATHF-----AEFLEQK------------CNFCGRYGASIN 158
            .....:|::.......|....|..:.|:.     .|...:|            |..|.:....:.
Zfish   756 AKKESVCLVCEQTGEDIVTCAGQCYGTYHLHCIGVERSAEKILCTACSTGVHVCFTCKKSEGEVR 820

  Fly   159 --CKMNCRQVHHWPCAAAAGCLLILESFTVF------CTEHLSQVPVICSDNNVECLSCSSLGDL 215
              |.::|.:.:|..|..       |.:.|||      |..|             .||||...|..
Zfish   821 RCCALHCGRFYHEACVR-------LSALTVFENRGFRCPLH-------------TCLSCHYSGRA 865

  Fly   216 S------KLIMCSTCGDHFH--STCIGLANLPDTRSGWNCA---RCTK------------CQICR 257
            :      |::.|..|...:|  ..|:...:...:.|...|.   |..|            |.||
Zfish   866 ACKATKGKMMRCLRCPVAYHVGDLCVAAGSEMISSSAIVCTNHFRAKKGYSHHSHVNVSWCFIC- 929

  Fly   258 QQDSNDTKYVKCEQCQKTYHASCLRPVISAIPKYGWKCNRCR----------VCTDCGS------ 306
               |...:.:.||.|...:|..||.   .|:|...|.||.||          :....|:
Zfish   930 ---SKGGRLLCCESCPAAFHPDCLN---IAMPDGSWFCNDCRSGKKPKYRDVIWVKLGNYRWWPA 988

  Fly   307 --RTPGG--------------------GSSSRWHSH------YTICD--SCYQQRNKGFSCPICQ 341
              |.|..                    ||...:.:|      |...|  |.|||...|
Zfish   989 EIRHPKNIPTNIQHLRHEIGEFPVFFFGSKDYFWTHQGRVFPYMEGDRGSKYQQTGIG------- 1046

  Fly   342 KAYRAA------SHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYV------------ 388
            |.::.|      ..||:              :.|.:....|:..::.|.:.|:
Zfish  1047 KVFKNALLDAETRFKEI--------------EMEREAKEAHENNKKPPPFKYIKVNKPCGRVQVY 1097

  Fly   389 ---------CPNCKSNSSGPGS-SQQTIDSIVLSAMDSSSEQLSLKEIELDPLEGKPTMDPSSDE 443
                     | |||.::..|.| ..:.::.::|                   .|..|.:.|:.:.
Zfish  1098 TADISEIPKC-NCKPSTERPCSFESECLNRMLL-------------------YECHPQVCPAGER 1142

  Fly   444 LHKLPTGKK-----KVCLTSVRG---------RSGKFVLHRMGVMSQINKKRSTRGKGRQLALPT 494
            .......|:     |:..|:.:|         :.|:||...:|.:
Zfish  1143 CQNQDFTKRLYPETKIIRTAGKGWGLISLRDIKKGEFVNEYVGEL-------------------- 1187

  Fly   495 ISSDRCLSR---SMETDLTSDKKLLLCSARDKFIQA--------------QDIC----------- 531
            |..:.|.||   :.|.|:|  ...:|...:|:.|.|              |..|
Zfish  1188 IDEEECRSRIRHAQENDIT--HFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDT 1250

  Fly   532 -----VMC--------------GSLGIESDSVMITCAQCGQCYHPYCAGV---KPSRG------- 567
                 .:|              ..||.|.     |..:||.   |.|:|.   :|..|
Zfish  1251 RVGLFAVCDIPAGTELTFNYNLDCLGNEK-----TVCRCGA---PNCSGFLGDRPKNGHTSEPKA 1307

  Fly   568 ILQK-----------GWRCLDCTVCEGCGKKNDEARLLLCDE--CDISYHIYCVNPPLETVPTGN 619
            .|||           |.:..|  .|..||   |..:|:|||:  |..:||:.|::....  |.|.
Zfish  1308 KLQKKKPKRKRARNEGKKSED--ECFRCG---DGGQLVLCDKKGCTKAYHLSCLDRTKR--PFGR 1365

  Fly   620 WKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCE-HCE--LWA 681
            |.|.: ..|..||:|                   |.:.|.:|..|:        |: |.|  |.:
Zfish  1366 WDCPW-HHCDVCGKN-------------------SAAFCQLCPNSF--------CKAHQEGALRS 1402

  Fly   682 HFHCDSVNAQLTI-DHYDNNV 701
            |    .:..||.. :|.|:::
Zfish  1403 H----PLTGQLCCQEHEDSDI 1419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lpt	NP_611847.2	ePHD1_KMT2C_like	109..191	CDD:277135	18/106 (17%)
		PHD1_KMT2C_like	205..250	CDD:276984	12/55 (22%)
		PHD2_KMT2C_like	252..298	CDD:276985	16/57 (28%)
		PHD_SF	337..392	CDD:304600	9/81 (11%)
		PHD4_KMT2C_like	530..578	CDD:276987	17/98 (17%)
		PHD5_KMT2C_like	580..625	CDD:276988	16/46 (35%)
		PHD6_KMT2C_like	657..707	CDD:276989	12/49 (24%)
		NHP6B	1101..>1237	CDD:227935
		HMG	1173..1231	CDD:197700
nsd2	NP_001076020.1	PWWP	283..394	CDD:295359
		DTHCT	688..>758	CDD:285332	16/66 (24%)
		PHD_SF	761..803	CDD:304600	6/41 (15%)
		PHD_SF	808..854	CDD:304600	11/52 (21%)
		PHD_SF	855..908	CDD:304600	12/52 (23%)
		PHD4_NSD2	925..965	CDD:277127	15/46 (33%)
		WHSC1_related	970..1063	CDD:99899	16/99 (16%)
		AWS	1103..1153	CDD:197795	11/69 (16%)
		SET	1154..1277	CDD:214614	22/144 (15%)
		PHD_SF	1329..1371	CDD:304600	16/47 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4489
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.030