DRSC/TRiP Functional Genomics Resources

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Protein Alignment Lpt and nsd2

DIOPT Version :10

Sequence 1:NP_611847.2 Gene:Lpt / 37795 FlyBaseID:FBgn0263667 Length:1482 Species:Drosophila melanogaster
Sequence 2:NP_001076020.1 Gene:nsd2 / 100000709 ZFINID:ZDB-GENE-030131-2581 Length:1461 Species:Danio rerio


Alignment Length:866 Identity:167/866 - (19%)
Similarity:261/866 - (30%) Gaps:360/866 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 PAPAEIKDKYPTDRLREDGSRLLYGPKQAASSSGDCHYELDKIGQP----DVVHPAEFLDE--GF 110
            |.|   |.|....|..|.|.:.....|:...||   :.|.::...|    |..||::..:.  | 
Zfish   698 PPP---KAKRGRKRKEESGRQSFPASKKCRPSS---YAEPERPDSPSDSTDESHPSKKAERTPG- 755

  Fly   111 VYVHRMCIMWSLRKSQISDADGAYFATHF-----AEFLEQK------------CNFCGRYGASIN 158
            .....:|::.......|....|..:.|:.     .|...:|            |..|.:....:.
Zfish   756 AKKESVCLVCEQTGEDIVTCAGQCYGTYHLHCIGVERSAEKILCTACSTGVHVCFTCKKSEGEVR 820

  Fly   159 --CKMNCRQVHHWPCAAAAGCLLILESFTVF------CTEHLSQVPVICSDNNVECLSCSSLGDL 215
              |.::|.:.:|..|..       |.:.|||      |..|             .||||...|..
Zfish   821 RCCALHCGRFYHEACVR-------LSALTVFENRGFRCPLH-------------TCLSCHYSGRA 865

  Fly   216 S------KLIMCSTCGDHFH--STCIGLANLPDTRSGWNCA---RCTK------------CQICR 257
            :      |::.|..|...:|  ..|:...:...:.|...|.   |..|            |.|| 
Zfish   866 ACKATKGKMMRCLRCPVAYHVGDLCVAAGSEMISSSAIVCTNHFRAKKGYSHHSHVNVSWCFIC- 929

  Fly   258 QQDSNDTKYVKCEQCQKTYHASCLRPVISAIPKYGWKCNRCR----------VCTDCGS------ 306
               |...:.:.||.|...:|..||.   .|:|...|.||.||          :....|:      
Zfish   930 ---SKGGRLLCCESCPAAFHPDCLN---IAMPDGSWFCNDCRSGKKPKYRDVIWVKLGNYRWWPA 988

  Fly   307 --RTPGG--------------------GSSSRWHSH------YTICD--SCYQQRNKGFSCPICQ 341
              |.|..                    ||...:.:|      |...|  |.|||...|       
Zfish   989 EIRHPKNIPTNIQHLRHEIGEFPVFFFGSKDYFWTHQGRVFPYMEGDRGSKYQQTGIG------- 1046

  Fly   342 KAYRAA------SHKEMVKCSWCNKFVHSTCDEEADLTAYHKKKEQNPDYDYV------------ 388
            |.::.|      ..||:              :.|.:....|:..::.|.:.|:            
Zfish  1047 KVFKNALLDAETRFKEI--------------EMEREAKEAHENNKKPPPFKYIKVNKPCGRVQVY 1097

  Fly   389 ---------CPNCKSNSSGPGS-SQQTIDSIVLSAMDSSSEQLSLKEIELDPLEGKPTMDPSSDE 443
                     | |||.::..|.| ..:.::.::|                   .|..|.:.|:.:.
Zfish  1098 TADISEIPKC-NCKPSTERPCSFESECLNRMLL-------------------YECHPQVCPAGER 1142

  Fly   444 LHKLPTGKK-----KVCLTSVRG---------RSGKFVLHRMGVMSQINKKRSTRGKGRQLALPT 494
            .......|:     |:..|:.:|         :.|:||...:|.:                    
Zfish  1143 CQNQDFTKRLYPETKIIRTAGKGWGLISLRDIKKGEFVNEYVGEL-------------------- 1187

  Fly   495 ISSDRCLSR---SMETDLTSDKKLLLCSARDKFIQA--------------QDIC----------- 531
            |..:.|.||   :.|.|:|  ...:|...:|:.|.|              |..|           
Zfish  1188 IDEEECRSRIRHAQENDIT--HFYMLTIDKDRIIDAGPKGNYSRFMNHSCQPNCETQKWTVNGDT 1250

  Fly   532 -----VMC--------------GSLGIESDSVMITCAQCGQCYHPYCAGV---KPSRG------- 567
                 .:|              ..||.|.     |..:||.   |.|:|.   :|..|       
Zfish  1251 RVGLFAVCDIPAGTELTFNYNLDCLGNEK-----TVCRCGA---PNCSGFLGDRPKNGHTSEPKA 1307

  Fly   568 ILQK-----------GWRCLDCTVCEGCGKKNDEARLLLCDE--CDISYHIYCVNPPLETVPTGN 619
            .|||           |.:..|  .|..||   |..:|:|||:  |..:||:.|::....  |.|.
Zfish  1308 KLQKKKPKRKRARNEGKKSED--ECFRCG---DGGQLVLCDKKGCTKAYHLSCLDRTKR--PFGR 1365

  Fly   620 WKCSFCTLCQKCGRNPTEKSEFGDSNMLECPSCTSQSSCPVCKVSYSNGEMIIQCE-HCE--LWA 681
            |.|.: ..|..||:|                   |.:.|.:|..|:        |: |.|  |.:
Zfish  1366 WDCPW-HHCDVCGKN-------------------SAAFCQLCPNSF--------CKAHQEGALRS 1402

  Fly   682 HFHCDSVNAQLTI-DHYDNNV 701
            |    .:..||.. :|.|:::
Zfish  1403 H----PLTGQLCCQEHEDSDI 1419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LptNP_611847.2 ePHD1_KMT2C_like 109..191 CDD:277135 18/106 (17%)
PHD1_KMT2C_like 205..250 CDD:276984 12/55 (22%)
PHD2_KMT2C_like 252..298 CDD:276985 16/57 (28%)
PHD_SF 337..392 CDD:473978 9/81 (11%)
PHD4_KMT2C_like 530..578 CDD:276987 17/98 (17%)
PHD5_KMT2C_like 580..625 CDD:276988 16/46 (35%)
PHD6_KMT2C_like 657..707 CDD:276989 12/49 (24%)
NHP6B 1101..>1237 CDD:227935
HMG_KMT2C-like 1157..1223 CDD:438813
nsd2NP_001076020.1 PWWP_NSD_rpt1 285..393 CDD:438972
ASY3-like <675..>751 CDD:466584 15/58 (26%)
PHD_SF 761..803 CDD:473978 6/41 (15%)
PHD_SF 808..854 CDD:473978 11/52 (21%)
PHD_SF 855..908 CDD:473978 12/52 (23%)
PHD4_NSD2 925..965 CDD:277127 15/46 (33%)
PWWP_NSD2_rpt2 971..1065 CDD:438993 17/114 (15%)
AWS 1116..1151 CDD:465559 6/53 (11%)
SET_NSD2 1153..1294 CDD:380988 30/170 (18%)
PHD_SF 1329..1371 CDD:473978 16/47 (34%)
C5HCH 1370..1415 CDD:465605 15/76 (20%)
Blue background indicates that the domain is not in the aligned region.

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