DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf3 and UPF3

DIOPT Version :9

Sequence 1:	NP_611844.3	Gene:	Upf3 / 37792	FlyBaseID:	FBgn0034923	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001117406.1	Gene:	UPF3 / 840295	AraportID:	AT1G33980	Length:	484	Species:	Arabidopsis thaliana

Alignment Length:	527	Identity:	131/527 - (24%)
Similarity:	210/527 - (39%)	Gaps:	134/527 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KIVMRHLPPTMTEAQFLDQVGPLPENDSYYYC-----KADWSLGQEATCRAYIDMSSKDIGEVVQ 90
            |:|:|||||:::::..|.|:.| ...|.|.:.     |:......:...|||:...:.:  :|.:
plant     9 KVVVRHLPPSLSQSDLLSQIDP-RFADRYNWVSFRPGKSRLGYKNQKYSRAYVSFKAPE--DVYE 70

  Fly    91 FRDRFDGYVFVDHKGVEYMAIVEYAPFQCFLKNKARNDDSKVNTIESEPHYQEFIKRLAQEREEA 155
            |...|:|:|||:.||.::.|||||||.|...|...:. |.:..:|..:|.|.||:|.:||..|..
plant    71 FAAFFNGHVFVNEKGAQFKAIVEYAPSQRVPKPSDKK-DPREGSISKDPDYLEFLKVIAQPVENL 134

  Fly   156 SRMGDVKIDFNFERRTEEKVKS-------TPLLQYLANKK----------EKRREEAR------- 196
            .     ..:...|||..|:..:       |||::::..|:          :.||...|
plant   135 P-----SAEIQLERREAEQSGASKAAPIVTPLMEFIRQKRATVMGPQGLSDIRRGGRRTRVVSAN 194

  Fly   197 -------RRNEEKRK--QREEQKLLRLAAQSDASKLKEAEGGGGGGDTKKPAKKDVKDPQSSGSQ 252
                   :||.||:|  ::|..|.:.....:|.|.                :|.|.:...|||.:
plant   195 KPSPRPSKRNSEKKKYVEKESSKNVPRKTTADVSS----------------SKPDYRQSNSSGKE 243

  Fly   253 --ANDAKA----SRSKRRTERDQRRREEHEQRKLVKRDKKKD--DGQGKQDKQDKQDKGKPSSGK 309
              .|:..|    |........|..::     :.|:.|.|.:|  |....|.:|........:|..
plant   244 LPGNETAAIIDSSPPGIALTMDSGKK-----KILLLRSKDRDNPDNPPPQPEQHIDTNLSRNSTD 303

  Fly   310 QNKNSKSMDI-------VILKKANKPESNESLDVPSTSNAAEASKEKPATENTETPEAAVKVFTP 367
            ..:|.|| |:       ::|:..::|..:      ||...:|...|....||.:.|.      .|
plant   304 SRQNQKS-DVGGRLIKGILLRNDSRPSQS------STFVQSEQRVEPSEAENYKRPS------RP 355

  Fly   368 AARGGRKEKRTGADKQPAGSAHETAEEAIKAAQFRASEERRIRNKDRPSIAIYQPKARIRASDEL 432
            |      ..|.|.|...:|:..|             .:|||.||||||...::.|  |...|::.
plant   356 A------NTRAGKDYHTSGTISE-------------KQERRTRNKDRPDRVMWAP--RRDGSEDQ 399

  Fly   433 PQGAGGKDG-------SDGEASVVE-------EKTSKR--NKRPNRRNKPKPKEVKECELETRRF 481
            |..:.|.:|       |.....||.       |..|.|  ::|...||:.:...:.|.: .:||.
plant   400 PLSSAGNNGEVKDRMFSQRSGEVVNSSGGHTLENGSARHSSRRVGGRNRKEEVVIGEGK-TSRRG 463

  Fly   482 SKSSESS 488
            |....||
plant   464 SGGGPSS 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf3	NP_611844.3	Smg4_UPF3	27..186	CDD:281466	51/166 (31%)
UPF3	NP_001117406.1	Smg4_UPF3	6..170	CDD:281466	52/169 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	76	1.000	Domainoid score	I3178
eggNOG	1	0.900	-	-		E1_KOG1295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I2249
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002677
OrthoInspector	1	1.000	-	-		oto4141
orthoMCL	1	0.900	-	-		OOG6_104140
Panther	1	1.100	-	-	LDO	PTHR13112
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.910