Protein Alignment Upf3 and Upf3a

DIOPT Version :10

• Sequence 1: NP_611844.3
• Gene: Upf3 / 37792
• FlyBaseID: FBgn0034923
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_080200.1
• Gene: Upf3a / 67031
• MGIID: 1914281
• Length: 422
• Species: Mus musculus
• Alignment Length: 389
• Identity: 118/389 - (30%)
• Similarity: 188/389 - (48%)
• Gaps: 92/389 - (23%)

  Fly     8 EKPKEKSKA---------SRRKDKKDKTNQIVKIVMRHLPPTMTEAQFLDQVGPLPENDSYYYCK 63
            |.|:::|.|         ...|.:::|...:.|:|:|.|||.:|:.|..:|:.|||.:|.:....
Mouse    35 ESPRKESAAPPAPTLSESGAGKPREEKRTALSKVVLRRLPPGLTKEQLEEQLRPLPAHDYFEVVA 99

  Fly    64 ADWSLGQEATCRAYIDMSSKDIGEVVQFRDRFDGYVFVDHKGVEYMAIVEYAPFQCFLKNKARND 128
            ||.||......||||:..:.|  :::.||||||||:|:.:||:||.|:||:||||...|.|.:..
Mouse   100 ADLSLYPHVYSRAYINFRNPD--DILLFRDRFDGYIFIGNKGLEYPAVVEFAPFQKIAKKKLKKK 162

  Fly   129 DSKVNTIESEPHYQEFIKRLAQEREEASR-----MGDVKIDFNFERRTEEKV--KSTPLLQYLAN 186
            |:|..:||.:|.|::|::..:.|.|:.|.     :|::      |.:|.|.:  ::||||:|:.|
Mouse   163 DAKTGSIEDDPEYKQFLESYSLEEEKTSASPETLLGEI------EAKTRELLARRTTPLLEYIKN 221

  Fly   187 KK-------EKRREEARRRNEEKRKQREEQKLLRLAAQSDASKLKEAE----------------- 227
            :|       |::|||.|||..||::.|||:|  |...:.|..|.||||
Mouse   222 RKLEKQRLREEKREERRRRELEKKRLREEEK--RKRREEDRCKRKEAERHKRAEKDVRIKLLKKL 284

  Fly   228 ---------------GGGGGGDTKKPAKKDVKDPQSSGSQANDA--KASRSKRRTERDQ------ 269
                           ...|.||.|:..:.....|:::|.:..|.  |..|.||..|:|.
Mouse   285 ETGEEVATEKPKERGEAVGAGDEKQEDRLVASQPETAGERLQDTSDKEPRDKRSREKDPETSRCH 349

  Fly   270 ----RRREEHEQRKLVKRDKKKDDGQGKQDKQDKQDKGKPS------------SGKQNKNSKSM 317
                |:...|.:   ..|..::::.:.|..|...||:||..            |||::|...|:
Mouse   350 PDTCRKHSSHSE---FARFSRRNEDEAKWGKGFAQDRGKKGQDGSVPMDVAERSGKEHKEYDSL 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf3	NP_611844.3	Smg4_UPF3	27..186	CDD:460932	63/165 (38%)
Upf3a	NP_080200.1	RRM_like_Smg4_UPF3A	64..150	CDD:410126	38/87 (44%)