Protein Alignment Upf3 and UPF3A

DIOPT Version :10

• Sequence 1: NP_611844.3
• Gene: Upf3 / 37792
• FlyBaseID: FBgn0034923
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_075387.1
• Gene: UPF3A / 65110
• HGNCID: 20332
• Length: 476
• Species: Homo sapiens
• Alignment Length: 469
• Identity: 138/469 - (29%)
• Similarity: 212/469 - (45%)
• Gaps: 102/469 - (21%)

  Fly     6 AEEKPKEKS--KASRRKDKKDKTNQIVKIVMRHLPPTMTEAQFLDQVGPLPENDSYYYCKADWSL 68
            ||..|...|  .....|.:::|...:.|:|:|.|||.:|:.|..:|:.|||.:|.:.:..||.||
Human    42 AETPPTSSSGCGGGAGKPREEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSL 106

  Fly    69 GQEATCRAYIDMSSKDIGEVVQFRDRFDGYVFVDHKGVEYMAIVEYAPFQCFLKNKARNDDSKVN 133
            ......||||:..:.|  :::.||||||||:|:|.||:||.|:||:||||...|.|.|..|:|..
Human   107 YPHLYSRAYINFRNPD--DILLFRDRFDGYIFLDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTG 169

  Fly   134 TIESEPHYQEFIKRLAQEREEASRMGDVKIDFNFERRTEEKV--KSTPLLQYLANKK-------E 189
            :||.:|.|::|::....|.|:.|...:..:. ..|.:|.|.:  ::||||:|:.|:|       |
Human   170 SIEDDPEYKKFLETYCVEEEKTSANPETLLG-EMEAKTRELIARRTTPLLEYIKNRKLEKQRIRE 233

  Fly   190 KRREEARRRNEEKRKQREEQKLLRLAAQSDASKLKEAEGGGGGGDTKKPAKKDV-----KDPQSS 249
            ::|||.|||..||::.|||:|  |...:.:..|.||.:      ..||.|:|:|     |.|:..
Human   234 EKREERRRRELEKKRLREEEK--RRRREEERCKKKETD------KQKKIAEKEVRIKLLKKPEKG 290

  Fly   250 GSQANDAKASRSKRRTERDQRRREEHEQRKLVKRDKKKDDGQGKQDK--QDKQDKGKPSSGKQNK 312
                       .:..||:.:.|.||            .|.|.|||:.  .....|.:|..|
Human   291 -----------EEPTTEKPKERGEE------------IDTGGGKQESCAPGAVVKARPMEG---- 328

  Fly   313 NSKSMDIVILKKANKPESNESLDVPSTSNAAEASKEKPATENTETPEAAVKVF------------ 365
                                ||:.|..::.:.:.||....|.::..|:..:.:
Human   329 --------------------SLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHH 373

  Fly   366 TPAARGGRKE--------------KRTGADKQPAGSAHETAEEAIKAAQFRASEERRIRNKDRPS 416
            .|.....|.|              |:...|....|.|.|....|.:.....|..:.|:.|||||:
Human   374 EPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPA 438

  Fly   417 IAIYQPKARIRASD 430
            :.:|.|.||.||.:
Human   439 LQLYDPGARFRARE 452

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf3	NP_611844.3	Smg4_UPF3	27..186	CDD:460932	64/160 (40%)
UPF3A	NP_075387.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		5/20 (25%)
		RRM_like_Smg4_UPF3A	66..152	CDD:410126	39/87 (45%)
		Required for interaction with UPF2	66..140		32/75 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	250..476		57/258 (22%)
		PRK12678	290..>473	CDD:237171	42/210 (20%)
		Required for association with EIF4A3 and ECJ core components CASC3, MAGOH and RBM8A	421..434		2/12 (17%)