Protein Alignment Upf3 and upf3a

DIOPT Version :9

• Sequence 1: NP_611844.3
• Gene: Upf3 / 37792
• FlyBaseID: FBgn0034923
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_001189377.1
• Gene: upf3a / 566608
• ZFINID: ZDB-GENE-060721-2
• Length: 478
• Species: Danio rerio
• Alignment Length: 485
• Identity: 139/485 - (28%)
• Similarity: 222/485 - (45%)
• Gaps: 125/485 - (25%)

  Fly    12 EKSKASRRKDKKDKTNQIVKIVMRHLPPTMTEAQFLDQVGPLPENDSYYYCKADWSLGQEATCRA 76
            :.:.|...|.|::|.....|:|:|.|||::::.|..:.:.|||..|.:.:..||.||......||
Zfish    25 QDNAAVNPKHKEEKKEIFSKVVIRRLPPSLSKDQLQEHLSPLPSFDYFEFFPADQSLYPHLFSRA 89

  Fly    77 YIDMSSKDIGEVVQFRDRFDGYVFVDHKGVEYMAIVEYAPFQCFLKNKARNDDSKVNTIESEPHY 141
            ||:..:.:  :::.||||||||||:|:||.||.|:||:||||...|.|.:..|:|..|||.:|.|
Zfish    90 YINFKNPE--DIIIFRDRFDGYVFIDNKGQEYPAVVEFAPFQKVSKKKLKKKDAKAGTIEEDPEY 152

  Fly   142 QEFIKRLAQEREEA-----SRMGDVKIDFNFERRTEEKV--KSTPLLQYLANKK-------EKRR 192
            :.|::..:.:.|::     :.:|::      |.:|.|.:  ::||||:|:.|||       |::|
Zfish   153 RRFLENYSCDEEKSMANPETLLGEI------EAKTRELIAKRTTPLLEYIKNKKLEKQRIREEKR 211

  Fly   193 EEARRRNEEKRKQREEQKLLRLAAQSDASKLKEAE------------------------------ 227
            ||.|||..||::||||:|  |...:.:..|.||||
Zfish   212 EERRRRELEKKRQREEEK--RKRREEERQKRKEAEKQKKLSEKEIKIKLLKKCDRDDDVDSDRLK 274

  Fly   228 --GGGG----------GGDTKKPAKKDVKDPQSSGSQANDAKASRSKRRTERDQRRREEHEQR-- 278
              |..|          ||.||   .||.||.:|......:.:....:|:.::|.|.|:|..:|
Zfish   275 DKGDSGETEKNRWEKPGGHTK---SKDSKDNRSQMENDKEQREGHGRRQRDKDHRGRDEERKRQR 336

  Fly   279 ------KLVKRDK-------------KKDDGQG---------KQDKQDKQDKGKPSSGKQNKNSK 315
                  |.::|.:             |||...|         |..|:|::|.|   |.|:...:|
Zfish   337 HHYEFDKFMRRKEETKWGKGYCQDRAKKDQHHGYSYCPETGDKLGKEDREDMG---SRKERIRNK 398

  Fly   316 SMDIVILKKANKPESNESLDVPSTSNAAEASKEKPATENTETPEAAVKVFTPAARGGRKEKRTGA 380
            |:.:...|:.::.|.      |.....|..:|::|          |::::.|   |.|..||.|:
Zfish   399 SVLVHQEKRTSQSEG------PDQIGGALPAKDRP----------AMQLYQP---GARNRKRMGS 444

  Fly   381 DKQ----PAGSAHETAEEAIKAAQFRASEE 406
            ..:    |..|.....|...|......||:
Zfish   445 GNKTFDFPPISPEHAGEHCYKTVIGTGSEK 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf3	NP_611844.3	Smg4_UPF3	27..186	CDD:281466	61/165 (37%)
upf3a	NP_001189377.1	Smg4_UPF3	43..200	CDD:281466	62/164 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579287
Domainoid	1	1.000	125	1.000	Domainoid score	I5417
eggNOG	1	0.900	-	-		E1_KOG1295
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	194	1.000	Inparanoid score	I3821
OMA	1	1.010	-	-		QHG46948
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002677
OrthoInspector	1	1.000	-	-		otm24511
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1758
SonicParanoid	1	1.000	-	-		X2445
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.890