DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DNAlig1 and AT1G49250

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_175351.1	Gene:	AT1G49250 / 841349	AraportID:	AT1G49250	Length:	657	Species:	Arabidopsis thaliana

Alignment Length:	713	Identity:	311/713 - (43%)
Similarity:	437/713 - (61%)	Gaps:	69/713 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 SASPETKPKVEPMSVDSEEKTSPVKNVKKEPKEVDDKT----TDKKVTTIGLNSTAATKEDVENY 104
            :||.:.|.|:|             :.|...|..|||||    :|.|
plant     3 NASAKKKRKLE-------------ETVDTPPTRVDDKTLVLISDSK------------------- 35

  Fly   105 DPSADSYHPLKNAYWKDKKVTPYLALARTFQVIEETK-GRLKMIDTLSNFFCSVMLVSPEDLVPS 168
            .|.:|....||:.....||              :.|: ||:.:...|.|...:|:..:|:||:|:
plant    36 KPKSDRVTKLKSKIGLLKK--------------KPTESGRIVITHILCNMLRTVIATTPDDLLPT 86

  Fly   169 VYLSINQLAPAYEGLELGVAE-TTLMKAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQRMMF 232
            |||:.|::|||:||::||:.: :.::|||.:|.||..:|::.|....||||:||..||.||.|:|
plant    87 VYLAANEIAPAHEGIKLGMGKGSYIIKAISEAFGRTESHVEQQYTQLGDLGLVANGSRSSQTMIF 151

  Fly   233 QPAPLNVRDVFRKLREIAKLSGQ----SKMDLVYNMFVACRSSEARFFIRSLIGKLRIGIAEQSL 293
            .|.||.|..|...||.|||.||:    .|.||:..:.||....|..:..|.|...||:|.:.|::
plant   152 MPKPLTVVKVADTLRLIAKESGKGSKDKKKDLMKALLVATTDCEPLYLTRLLQDNLRLGFSRQTV 216

  Fly   294 LTALAIGLV-KKNHIDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKYDIKELQE 357
            |.||....| .:.|      ||.|...|:.:.:...::|..:...|.||||:.|:|...:..|.:
plant   217 LAALGQAAVYNEEH------SKPPPNIKNPLDEAATIVKEVFSMLPVYDIIVGALLTSGVWNLPK 275

  Fly   358 RCPMHPGMPLRPMLAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIFSRNSENNT 422
            .|.:..|:|:|||||:.|..|..:.|:|.....|.|:|||||||||:..|.|.:.||||::|.||
plant   276 TCNLTLGVPVRPMLAKATTRVDLILEKFKDTVFTAEYKYDGERAQIYYMEDGTVEIFSRHAERNT 340

  Fly   423 AKYPDLIARSTALLKGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKVQVCVYIF 487
            .||||:....:.|.|..|||:|:|.|:|.::.|:::|||.|  |||..|||::.:|||.|||:.|
plant   341 GKYPDVALVLSRLKKPTVKSFILDCEVVTFNREKEKILPLQ--STRAHKNVNVSDIKVGVCVFAF 403

  Fly   488 DLLYINGTALVTKNLSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVK 552
            |:||:||..|:.:||:.||:.|.:.|:|..|.::|||||.:|||.|:|:||:.||...|||||:|
plant   404 DILYLNGQLLIHENLNIRREKLHDSFEEDLGYFQFATALTSNDIGELQEFLKASIDIGCEGLMIK 468

  Fly   553 TLDEEATYEIAKRSRNWLKLKKDYLSNVGDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENEEY 617
            :|...||||.||||.|||||||||:.|:|||:|||.|..:.|:|:|||.:|.:||||||.:.||:
plant   469 SLYSNATYEPAKRSNNWLKLKKDYMDNIGDSVDLVPIATFHGRGKRTGFFGAYLLACYDVDKEEF 533

  Fly   618 QSICKIGTGFTDEDLQTHSEFLGKHVTSAAKSYYRYDPSLEPDHWFEPVQVWEVKCADLSLSPIH 682
            ||||||||.|:|.:||..|..|...|.:..|.||:.|..|.||.|.||.:|||||.|||::||::
plant   534 QSICKIGTEFSDVELQDLSSSLCSKVIATPKQYYQVDNDLNPDVWLEPTEVWEVKAADLTVSPVY 598

  Fly   683 RAAIGIVDGERGISLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNNQKSSTQMEMEDE 745
            |.||||||.::||||||||.:|||.|||.|.||.::|:|.|||:|   |:||.|: |.:::|:
plant   599 REAIGIVDPDKGISLRFPRLVRIRKDKNPEEATTSDQIAEMYQAQ---KHNQPSN-QGKVDDD 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	310/711 (44%)
		DNA_ligase_A_N	126..292	CDD:282522	64/171 (37%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	113/217 (52%)
		OBF_DNA_ligase_I	581..726	CDD:153438	84/144 (58%)
AT1G49250	NP_175351.1	PLN03113	2..657	CDD:215584	310/711 (44%)
		DNA_ligase_A_N	57..216	CDD:282522	65/158 (41%)
		Adenylation_DNA_ligase_I_Euk	276..492	CDD:185710	113/217 (52%)
		OBF_DNA_ligase_I	497..642	CDD:153438	84/144 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	249	1.000	Domainoid score	I526
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H197
Inparanoid	1	1.050	632	1.000	Inparanoid score	I195
OMA	1	1.010	-	-		QHG56362
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	1	1.000	-	-		FOG0002684
OrthoInspector	1	1.000	-	-		otm3388
orthoMCL	1	0.900	-	-		OOG6_100906
Panther	1	1.100	-	-	O	PTHR45674
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2056
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840