DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig1 and Lig1

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_038947878.1	Gene:	Lig1 / 81513	RGDID:	621424	Length:	928	Species:	Rattus norvegicus

Alignment Length:	775	Identity:	379/775 - (48%)
Similarity:	518/775 - (66%)	Gaps:	48/775 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KKKSDATDSPSP--------PKKVPKIDAKTELPDEPHIKSES-------------ASPETKPKV 53
            |:|.:.|.:|:.        .:|..:::.:..:|.||....||             |..:.||:.
  Rat   161 KRKKEDTQTPTESLTEAEEVKQKEEQVEDQPTVPPEPTESPESVTLTKTENIPMCKAGVKQKPQE 225

  Fly    54 EPMSVDSEEKTSPVKN--------VKKEPKEVDDKTTDKKVTTIGLNSTAATKEDVENYDPSADS 110
            |..|........|:.:        ||.|.|: ::..|.:|..|.|       ..|..||:||..:
  Rat   226 EEQSKPPARGAKPLSSFFTPRKPAVKTEVKQ-EESDTPRKEETKG-------APDPTNYNPSKSN 282

  Fly   111 YHPLKNAYWKDKKVTPYLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSPEDLVPSVYLSINQ 175
            |||:::|.||..:..|:||:||||:.|||...||||::||||...||:.:||.||:|.:|||:|:
  Rat   283 YHPIEDACWKHGQKVPFLAVARTFEKIEEVSARLKMVETLSNLLRSVVALSPTDLLPVLYLSLNR 347

  Fly   176 LAPAYEGLELGVAETTLMKAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQRMMFQPAPLNVR 240
            |.|..:||||||.:..|:||:.:||||.|..|:::....||:|:|||.||.:||:|..|.||.|.
  Rat   348 LGPPQQGLELGVGDGVLLKAVAQATGRQLESIRAEVAEKGDVGLVAENSRSTQRLMLPPPPLTVS 412

  Fly   241 DVFRKLREIAKLSGQS----KMDLVYNMFVACRSSEARFFIRSLIGKLRIGIAEQSLLTAL--AI 299
            .||.|..:||:|:|.:    |||::..:|||||.|||||..|||.|:||:|:||||:|.||  |:
  Rat   413 GVFTKFCDIARLTGSASMAKKMDIIKGLFVACRYSEARFIARSLSGRLRLGLAEQSVLAALAQAV 477

  Fly   300 GLVKKNH-----IDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKYDIKELQERC 359
            .|.....     :.|....|..:..|..:.:..::||..:|:.|:.|.|||.:|::.::.|.|.|
  Rat   478 SLTPPGQEFPTAVVDAGKGKTAEARKMWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLESLPEHC 542

  Fly   360 PMHPGMPLRPMLAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIFSRNSENNTAK 424
            .:.||:||:||||.||:||.||.:||..:..|||:||||:|||||..|.||:.|||||.|:|:.|
  Rat   543 KLSPGVPLKPMLAHPTRGVREVLKRFEEVDFTCEYKYDGQRAQIHVLEGGEVKIFSRNQEDNSGK 607

  Fly   425 YPDLIARSTALLKGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKVQVCVYIFDL 489
            |||:|:|...:....|.|:|:|:|.||||.|:|||.|||||:|||||.||..||:||||:|.|||
  Rat   608 YPDIISRIPKIKHPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDL 672

  Fly   490 LYINGTALVTKNLSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVKTL 554
            :|:||.:|..:.||.||:||.|:|.|.|||:.|||:|||.||:::.:|||:|:|.:|||||||||
  Rat   673 IYLNGESLARQPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTL 737

  Fly   555 DEEATYEIAKRSRNWLKLKKDYLSNVGDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENEEYQS 619
            |.:|||||||||.||||||||||..|||:|||||||.|.|:|:|.|.|||||||.||.|:||.|:
  Rat   738 DVDATYEIAKRSHNWLKLKKDYLEGVGDTLDLVVIGAYLGRGKRAGRYGGFLLAAYDEESEELQA 802

  Fly   620 ICKIGTGFTDEDLQTHSEFLGKHVTSAAKSYYRYDPSLEPDHWFEPVQVWEVKCADLSLSPIHRA 684
            |||:||||:||:|:.|.:.:...:....:.|.|.|.::.||||.:|..||||||||||||||:.|
  Rat   803 ICKLGTGFSDEELEEHHQSMQALLLPTPRPYVRIDGAVAPDHWLDPSVVWEVKCADLSLSPIYPA 867

  Fly   685 AIGIVDGERGISLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNNQKSSTQMEMED 744
            |.|:||.|:|||||||||||:|:||..|.||.::|||.:|:.|.|::|.|.|....::||
  Rat   868 ARGLVDKEKGISLRFPRFIRVREDKQPEQATTSDQVASLYRKQSQIQNQQSSDLDSDVED 927

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	379/775 (49%)
		DNA_ligase_A_N	126..292	CDD:282522	90/169 (53%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	135/217 (62%)
		OBF_DNA_ligase_I	581..726	CDD:153438	87/144 (60%)
Lig1	XP_038947878.1	PTZ00121	<2..270	CDD:173412	24/116 (21%)
Lig1	XP_038947878.1	PLN03113	174..924	CDD:215584	373/757 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351029
Domainoid	1	1.000	269	1.000	Domainoid score	I1771
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H197
Inparanoid	1	1.050	733	1.000	Inparanoid score	I580
OMA	1	1.010	-	-		QHG56362
OrthoDB	1	1.010	-	-		D182401at33208
OrthoFinder	1	1.000	-	-		FOG0002684
OrthoInspector	1	1.000	-	-		otm45615
orthoMCL	1	0.900	-	-		OOG6_100906
Panther	1	1.100	-	-	O	PTHR45674
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810