DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig1 and lig1

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001119860.1	Gene:	lig1 / 556995	ZFINID:	ZDB-GENE-110404-2	Length:	1058	Species:	Danio rerio

Alignment Length:	768	Identity:	409/768 - (53%)
Similarity:	528/768 - (68%)	Gaps:	39/768 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KKKSD--ATDSPSPPKKVPKIDAKTELPDEPHIKSESASPETKPKVEPMSVDSEEKTSPVKN--- 69
            |.|||  ..:.....:||...:.|.::||:.  ..||:|||...|.|..:.....|..|:.:
Zfish   299 KDKSDKKQEEKDKTEEKVNGENEKEKIPDKK--GKESSSPEKVVKKEKDTDGGSAKKKPISSFFA 361

  Fly    70 -------VKKEPKEVDDKTTDKKVTTIGLNSTAATKEDVEN-----YDPSADSYHPLKNAYWKDK 122
                   ::||.:...:|..|.:.:.:.......:::.|::     ||||...|||:.:|.||..
Zfish   362 PRKAAVKLEKEERNEGEKKKDGETSDVVEQKEKKSEKGVDSAVQSQYDPSRAHYHPIDHACWKKG 426

  Fly   123 KVTPYLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSPEDLVPSVYLSINQLAPAYEGLELGV 187
            :..||||:||||:.|||..||||.|:|||||..||:|:||:||:..|||.:|||.|||:|||||:
Zfish   427 QKVPYLAVARTFEKIEEDSGRLKNIETLSNFLRSVILLSPDDLLCCVYLCLNQLGPAYQGLELGI 491

  Fly   188 AETTLMKAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQRMMFQPAPLNVRDVFRKLREIAKL 252
            .||.||||:.:||||.|..||::.|..||||:|||.||.:|||||.||.|....||.||:|||.:
Zfish   492 GETVLMKAVAQATGRQLDKIKAEAQEKGDLGLVAESSRSNQRMMFAPANLTAGGVFNKLKEIAHM 556

  Fly   253 SGQS----KMDLVYNMFVACRSSEARFFIRSLIGKLRIGIAEQSLLTAL--AIGLVKKNH----- 306
            ||.|    |:|::..:|||||.||||:.:|||.||||||:||||:|.||  |:.|.....
Zfish   557 SGNSAMNKKIDIIKGLFVACRFSEARYIVRSLAGKLRIGLAEQSVLAALSQAVCLTPPGQEFPPA 621

  Fly   307 -IDDCKASKVPD--VYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKYDIKELQERCPMHPGMPLR 368
             :|..|.....:  |:.:|   ..|:||..||:.||||.|||.:||..|.||...|.:.||:|||
Zfish   622 VLDAGKGMSTENRRVFLEE---KALILKQTYCEMPNYDAIIPVLLKEGIDELPNHCKLTPGVPLR 683

  Fly   369 PMLAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIFSRNSENNTAKYPDLIARST 433
            ||||.|||||.||.:||.....|||:||||||||||..|.||:.|||||.|:||:||||:|:|..
Zfish   684 PMLAHPTKGVGEVMKRFDEASFTCEYKYDGERAQIHILENGEVRIFSRNQEDNTSKYPDIISRIP 748

  Fly   434 ALLKGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKVQVCVYIFDLLYINGTALV 498
            .:.|..|:|.::|||.||||.|:|||.|||||:|||||:||..|||||||||.|||||:||.:||
Zfish   749 QVKKESVRSCVLDSEAVAWDREKKQIQPFQVLTTRKRKDVDASEIKVQVCVYAFDLLYLNGESLV 813

  Fly   499 TKNLSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVKTLDEEATYEIA 563
            .:.||:||.||.|.|.|.|||:.||.:||.::.:.:.:|||:|::.:|||||||||::.||||||
Zfish   814 REPLSKRRALLRESFVEKEGEFVFARSLDADNTETIAEFLEQSVRDSCEGLMVKTLEKHATYEIA 878

  Fly   564 KRSRNWLKLKKDYLSNVGDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENEEYQSICKIGTGFT 628
            |||.||||||||||..|||::||.|||.|.|||:|.|.||||||||||.||||:||:|||||||.
Zfish   879 KRSHNWLKLKKDYLEGVGDTVDLCVIGAYLGKGKRAGGYGGFLLACYDEENEEFQSVCKIGTGFK 943

  Fly   629 DEDLQTHSEFLGKHVTSAAKSYYRYDPSLEPDHWFEPVQVWEVKCADLSLSPIHRAAIGIVDGER 693
            ||||:.|..||.:|:....:.|||.|.|.|||.|.|.|||||||||||||||:::||:|:||.|:
Zfish   944 DEDLEQHYNFLKEHILPKPRPYYRVDQSAEPDVWLEAVQVWEVKCADLSLSPVYKAAMGLVDPEK 1008

  Fly   694 GISLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNNQKSSTQMEMEDEF 746
            |||||||||:||||||..|:||..:|:|.:|:.|.|::|   ...:.::||.:
Zfish  1009 GISLRFPRFLRIRDDKKPEDATTGSQIADLYKKQQQIQN---QGDKPDLEDYY 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	408/765 (53%)
		DNA_ligase_A_N	126..292	CDD:282522	105/169 (62%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	138/217 (64%)
		OBF_DNA_ligase_I	581..726	CDD:153438	96/144 (67%)
lig1	NP_001119860.1	PLN03113	301..1053	CDD:215584	406/759 (53%)
		DNA_ligase_A_N	430..601	CDD:282522	106/170 (62%)
		Adenylation_DNA_ligase_I_Euk	673..891	CDD:185710	138/217 (64%)
		OBF_DNA_ligase_I	896..1041	CDD:153438	96/144 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592758
Domainoid	1	1.000	267	1.000	Domainoid score	I1836
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H197
Inparanoid	1	1.050	771	1.000	Inparanoid score	I521
OMA	1	1.010	-	-		QHG56362
OrthoDB	1	1.010	-	-		D182401at33208
OrthoFinder	1	1.000	-	-		FOG0002684
OrthoInspector	1	1.000	-	-		oto40930
orthoMCL	1	0.900	-	-		OOG6_100906
Panther	1	1.100	-	-	LDO	PTHR45674
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2092
SonicParanoid	1	1.000	-	-		X2056
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800