DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig1 and LIG3

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	XP_005258027.1	Gene:	LIG3 / 3980	HGNCID:	6600	Length:	1018	Species:	Homo sapiens

Alignment Length:	829	Identity:	207/829 - (24%)
Similarity:	347/829 - (41%)	Gaps:	214/829 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ITSFFKKKSDATDSPSPPKKVPKIDAKTELPDE------PHIKSESA----SPETKPKVEPMSVD 59
            |...|:|...|..:....:.:.:::...||.|.      .||...|:    :|:.|..|:.....
Human   149 IKCMFEKLERARATTKKIEDLTELEGWEELEDNEKEQITQHIADLSSKAAGTPKKKAVVQAKLTT 213

  Fly    60 SEEKTSPVK--------NVKK------EPK---EVDDKTTDKKVTTIGLNSTAATKEDVENYDPS 107
            :.:.|||||        |.:|      :|.   |.....|.|:       |.:::|.|..:.|..
Human   214 TGQVTSPVKGASFVTSTNPRKFSGFSAKPNNSGEAPSSPTPKR-------SLSSSKCDPRHKDCL 271

  Fly   108 ADSYHPL-----KNAYWKDKKVTPYLALARTFQVIEE--TKGRLKMIDTLSNFFCSVMLVSPEDL 165
            ...:..|     .|..:..|.           |:|::  .||.                 :.:..
Human   272 LREFRKLCAMVADNPSYNTKT-----------QIIQDFLRKGS-----------------AGDGF 308

  Fly   166 VPSVYLSINQLAPAYEGLELGVAETTLM---KAICKATGR-------NLAHIKSQTQLTGDLGIV 220
            ...|||::..|.|       ||.:|...   |.|.|...|       ::|....|..::..:.:.
Human   309 HGDVYLTVKLLLP-------GVIKTVYNLNDKQIVKLFSRIFNCNPDDMARDLEQGDVSETIRVF 366

  Fly   221 AEQSRVSQRMMFQPAP---LNVRDVFRKLREIAKLSGQ-SKMDLVYNMFVACRSSEARFFIRSLI 281
            .|||:     .|.||.   |.:::|...|..::||:.: .:...:.::...|.:::.:..||.:.
Human   367 FEQSK-----SFPPAAKSLLTIQEVDEFLLRLSKLTKEDEQQQALQDIASRCTANDLKCIIRLIK 426

  Fly   282 GKLRIGIAEQSLLTALAIGLVKKNHIDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPA 346
            ..|::....:.:|.||.                 |:.|:            |:....|...::..
Human   427 HDLKMNSGAKHVLDALD-----------------PNAYE------------AFKASRNLQDVVER 462

  Fly   347 ILKYDIKELQERCPMHPGM------------PLRPMLAQPTKGVHEVFERF-GGMQITCEWKYDG 398
            :| ::.:|:::    .||.            |::||||:..|.|....::. .||  ..|.||||
Human   463 VL-HNAQEVEK----EPGQRRALSVQASLMTPVQPMLAEACKSVEYAMKKCPNGM--FSEIKYDG 520

  Fly   399 ERAQIHRNEKGE-ISIFSRNSE----NNTAKYPDLIARSTALLKGDVKSYIIDSEIVAWDVERKQ 458
            ||.|:|:|  |: .|.|||:.:    :..|.:.|.|.::   ..|. .|.|:|||::..|.:..:
Human   521 ERVQVHKN--GDHFSYFSRSLKPVLPHKVAHFKDYIPQA---FPGG-HSMILDSEVLLIDNKTGK 579

  Fly   459 ILPFQVLSTRKRKNVDIEEIKVQVCVYIFDLLYINGTALVTKNLSERRKLLLEHFQEVEGEWKFA 523
            .|||..|...|:....    ...||:::||.:|.|..:|:.:.|.||||.|.::..|:.....|:
Human   580 PLPFGTLGVHKKAAFQ----DANVCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPNRIMFS 640

  Fly   524 ------TALDTNDIDEVQQFLEESIKGNCEGLMVKTLDEEATYEIAKRSRNWLKLKKDYLSN--V 580
                  .|||..|:  :.:.::|.:    |||::|  |.:.|||..|  |:|||:|||||:.  :
Human   641 EMKRVTKALDLADM--ITRVIQEGL----EGLVLK--DVKGTYEPGK--RHWLKVKKDYLNEGAM 695

  Fly   581 GDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENEEYQSICKIGTGFTDEDLQTHSEFLGKHVTS 645
            .|:.||||:|.:.|:|.:.|....||:.|||..::::.::.|...|..|..|......|  .:..
Human   696 ADTADLVVLGAFYGQGSKGGMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNEL--DMVK 758

  Fly   646 AAKSYYRYDPSLEPDHWF---------------EPVQVWEVKCADLSLSPIHRAAIGIVDGERGI 695
            .:|     |||..|. |.               :...|||:..|:.|.|..|.|        .||
Human   759 ISK-----DPSKIPS-WLKVNKIYYPDFIVPDPKKAAVWEITGAEFSKSEAHTA--------DGI 809

  Fly   696 SLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQ------VKNNQKSST 738
            |:||||..||||||:.::||:..|:..:||...:      |..::.|||
Human   810 SIRFPRCTRIRDDKDWKSATNLPQLKELYQLSKEKADFTVVAGDEGSST 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	207/829 (25%)
		DNA_ligase_A_N	126..292	CDD:282522	33/181 (18%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	76/241 (32%)
		OBF_DNA_ligase_I	581..726	CDD:153438	50/159 (31%)
LIG3	XP_005258027.1	zf-PARP	106..188	CDD:279039	7/38 (18%)
		DNA_ligase_A_N	273..438	CDD:282522	36/204 (18%)
		dnl1	327..839	CDD:273147	158/588 (27%)
		Adenylation_DNA_ligase_III	477..689	CDD:185712	74/233 (32%)
		OBF_DNA_ligase_III	695..833	CDD:153436	48/153 (31%)
		LIG3_BRCT	942..1013	CDD:293364
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D274264at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820