DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig1 and LIG1

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_000225.1	Gene:	LIG1 / 3978	HGNCID:	6598	Length:	919	Species:	Homo sapiens

Alignment Length:	766	Identity:	377/766 - (49%)
Similarity:	515/766 - (67%)	Gaps:	47/766 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KKKSDATDSP-SPPK--KVPKIDAKTELPDEPHIKSESASPETKPKVEPMSVDSEEKTSPVKN-- 69
            :|:.:..|.| :|||  |..|.:..||...||.:       .||.:::    :.||:|.|.:.
Human   172 EKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEV-------ATKQELQ----EEEEQTKPPRRAP 225

  Fly    70 -------------VKKEPKEVDDKTTDKKVTTIGLNSTAATKEDVENYDPSADSYHPLKNAYWKD 121
                         ||||.||.:.....|:       ..|....|...|:|:.::|||:::|.||.
Human   226 KTLSSFFTPRKPAVKKEVKEEEPGAPGKE-------GAAEGPLDPSGYNPAKNNYHPVEDACWKP 283

  Fly   122 KKVTPYLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSPEDLVPSVYLSINQLAPAYEGLELG 186
            .:..||||:||||:.|||...||:|::||||...||:.:||.||:|.:|||:|.|.|..:|||||
Human   284 GQKVPYLAVARTFEKIEEVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELG 348

  Fly   187 VAETTLMKAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQRMMFQPAPLNVRDVFRKLREIAK 251
            |.:..|:||:.:||||.|..::::....||:|:|||.||.:||:|..|.||....||.|.|:||:
Human   349 VGDGVLLKAVAQATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIAR 413

  Fly   252 LSGQS----KMDLVYNMFVACRSSEARFFIRSLIGKLRIGIAEQSLLTAL--AIGLVKKNH---- 306
            |:|.:    |:|::..:|||||.|||||..|||.|:||:|:||||:|.||  |:.|.....
Human   414 LTGSASTAKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPP 478

  Fly   307 -IDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKYDIKELQERCPMHPGMPLRPM 370
             :.|....|..:..|..:.:..::||..:|:.|:.|.|||.:|::.::.|.|.|.:.||:||:||
Human   479 AMVDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPLKPM 543

  Fly   371 LAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIFSRNSENNTAKYPDLIARSTAL 435
            ||.||:|:.||.:||.....|||:||||:|||||..|.||:.|||||.|:||.||||:|:|...:
Human   544 LAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPDIISRIPKI 608

  Fly   436 LKGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKVQVCVYIFDLLYINGTALVTK 500
            ....|.|:|:|:|.||||.|:|||.|||||:|||||.||..||:||||:|.|||:|:||.:||.:
Human   609 KLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVRE 673

  Fly   501 NLSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVKTLDEEATYEIAKR 565
            .||.||:||.|:|.|.|||:.|||:|||.||:::.:|||:|:|.:||||||||||.:||||||||
Human   674 PLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKR 738

  Fly   566 SRNWLKLKKDYLSNVGDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENEEYQSICKIGTGFTDE 630
            |.||||||||||..|||:|||||||.|.|:|:|.|.|||||||.||.::||.|:|||:||||:||
Human   739 SHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLASYDEDSEELQAICKLGTGFSDE 803

  Fly   631 DLQTHSEFLGKHVTSAAKSYYRYDPSLEPDHWFEPVQVWEVKCADLSLSPIHRAAIGIVDGERGI 695
            :|:.|.:.|...|..:.:.|.|.|.::.||||.:|..||||||||||||||:.||.|:||.::||
Human   804 ELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSAVWEVKCADLSLSPIYPAARGLVDSDKGI 868

  Fly   696 SLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNNQKSSTQMEMEDEF 746
            |||||||||:|:||..|.||.:.|||.:|:.|.|::|.|...:..:.||.:
Human   869 SLRFPRFIRVREDKQPEQATTSAQVACLYRKQSQIQNQQGEDSGSDPEDTY 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	376/763 (49%)
		DNA_ligase_A_N	126..292	CDD:282522	88/169 (52%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	136/217 (63%)
		OBF_DNA_ligase_I	581..726	CDD:153438	87/144 (60%)
LIG1	NP_000225.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..270		29/115 (25%)
		DUF4045	<10..275	CDD:330572	30/120 (25%)
		CDC9	164..914	CDD:330238	375/759 (49%)
		Interaction with target DNA	449..458		5/8 (63%)
		Interaction with target DNA	642..644		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157069
Domainoid	1	1.000	271	1.000	Domainoid score	I1822
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H197
Inparanoid	1	1.050	732	1.000	Inparanoid score	I611
Isobase	1	0.950	-	0	Normalized mean entropy	S1058
OMA	1	1.010	-	-		QHG56362
OrthoDB	1	1.010	-	-		D182401at33208
OrthoFinder	1	1.000	-	-		FOG0002684
OrthoInspector	1	1.000	-	-		oto90281
orthoMCL	1	0.900	-	-		OOG6_100906
Panther	1	1.100	-	-	LDO	PTHR45674
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2092
SonicParanoid	1	1.000	-	-		X2056
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750