Protein Alignment DNAlig1 and DNAlig4

DIOPT Version :10

• Sequence 1: NP_611843.2
• Gene: DNAlig1 / 37791
• FlyBaseID: FBgn0262619
• Length: 747
• Species: Drosophila melanogaster
• Sequence 2: NP_572907.1
• Gene: DNAlig4 / 32322
• FlyBaseID: FBgn0030506
• Length: 918
• Species: Drosophila melanogaster
• Alignment Length: 634
• Identity: 150/634 - (23%)
• Similarity: 247/634 - (38%)
• Gaps: 111/634 - (17%)

  Fly   162 PEDLVPSVYLSINQLAPAYE------GLELGVAETTLMKAICKATGRNLAHIKSQTQ---LTGDL 217
            |||...|.|..:..|.|..:      ||::.......::.:...|..:.| |:.|.:   :..|.
  Fly    59 PEDGASSFYSVLRLLLPGADTGRDTYGLQITALGRLYIRVLQLPTDSSDA-IRLQHRNGNMYRDY 122

  Fly   218 GIVAEQSRVSQRMMFQPAPLNVRDVFRKLREIAKLSGQSKMDLVYNMFVACRSSEARFFIRSLIG 282
            |.|. .|.:..|....|:.|.::::.:.|..||....:.|...:..........|.::.||.|:.
  Fly   123 GDVV-YSVLKPRCFNPPSNLRLKEIHQMLDTIANEDTEVKQQQLIRFTEQASPEEQKWLIRLLLK 186

  Fly   283 KLRIGIAEQSLLTAL---AIGLVKK----NHIDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNY 340
            .|.:||.||.:...|   |..:.::    .|:.:..|.:..|:......|:...:|..     |.
  Fly   187 SLGLGIGEQKIFGVLHPKAQDIYQRCSDLGHVCNLLADRTTDLDASSSKDSKAAVKFV-----NL 246

  Fly   341 DIIIPAILKYDIKELQERCPMHPGMPLRPMLAQPTKGVHEVFERFGG-----MQ---ITCEWKYD 397
            :.:|.              |.|   .:||||.          |||.|     ||   :..|.|.|
  Fly   247 NSVIR--------------PFH---QIRPMLC----------ERFPGDIQELMQSDVLYLETKMD 284

  Fly   398 GERAQIHRNEKGEISIFSRNSENNTAKY------PDLIARSTALLKGDVKSYIIDSEIVAWDVER 456
            |||.|:| .::|.....|||..:.|..:      ..|..:...||...::|.|:|.|::.||..:
  Fly   285 GERFQLH-IDRGRFMYISRNGVDYTRNFGHSYDHGTLTPKLRGLLPLGLESIILDGEMMVWDTNK 348

  Fly   457 KQILPFQVLSTRKRKNVDIEEIKV----QVCVYIFDLLYINGTALVTKNLSERRKLLLEHFQEVE 517
               |.|:    .|.:|.|::.:|.    |.|..::||||.||.:|:.....:|...|.:...|..
  Fly   349 ---LRFR----EKGENTDVKSLKPEGSWQPCFVVYDLLYFNGQSLLDHTYIQRAYKLQKLIVEQS 406

  Fly   518 GEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVKTLDEEATYEIAKR-SRNWLKLKKDYLSNVG 581
            |..:...|.....:.|..:..::::..:.||:::|  .:.:.|:...| ...|.|.|.||:..:.
  Fly   407 GVLQLMRARKIGSVQEFNELFQQALDSHAEGIVLK--KQGSRYQPGVRLGGGWYKDKADYIKGLI 469

  Fly   582 DSLDLVVIGGYKGKGRRTGTY-GGFLLACY------DTENEEYQSICKIGTGFTDEDLQTHSEFL 639
            ...|:::||.:..:.|   |: ..|||...      .:...|..||..:........:..|:  |
  Fly   470 TEFDVLIIGAFYNRKR---TFVDSFLLGVLQPAPPGSSNRPEVFSIGVVANNTKQRGVLNHT--L 529

  Fly   640 GKH----VTSAAKSYYRYDPSLE---PDHWFEPVQ--VWEVKCADLSLSPIHRAAIGIVDGERGI 695
            ..|    |......::.|.|...   ||.|.||..  :.:||.|||       |..|.....:
  Fly   530 KPHWHDVVNEPPPLWFHYKPKERSGCPDLWIEPQNSVILQVKAADL-------APNGAFFTRK-- 585

  Fly   696 SLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNNQKSSTQMEMED 744
            ||.|||....||||.........:...:......:|...|  .|:.:||
  Fly   586 SLHFPRTEMKRDDKTWSECMTLKEFNDLCGGPLAIKKLNK--RQLRLED 632

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	150/634 (24%)
DNAlig4	NP_572907.1	dnl1	84..613	CDD:273147	138/586 (24%)
		Adenylation_DNA_ligase_IV	249..466	CDD:185713	66/253 (26%)
		BRCT	670..760	CDD:469589
		BRCT_2	830..917	CDD:465186