DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig1 and cdc17

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_593318.2	Gene:	cdc17 / 2541849	PomBaseID:	SPAC20G8.01	Length:	768	Species:	Schizosaccharomyces pombe

Alignment Length:	760	Identity:	320/760 - (42%)
Similarity:	468/760 - (61%)	Gaps:	44/760 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 QKSITSFFKKKSDATDSPSPPKKVPKIDAKTELPDEPHIKSESASPETKPKVEPMSVDSEEK--- 63
            |..|::||        ..|...|...::......|..::...|.|  .|.|||.:.:..|.|
pombe    24 QSDISNFF--------ISSASHKSEHVEVSQSSSDSKNVDGRSTS--EKRKVESVKLVDESKHNN 78

  Fly    64 --TSPVKNVKKEPKEVDDKTTDKKVTTIGLNSTAATKEDVENYDPSADSYHPL--------KNAY 118
              .:..:||::|...|.:.   ||..|:| :|::::.....|.|..|.:..||        .||
pombe    79 HDDTGTQNVERENNIVSEA---KKQKTLG-SSSSSSDAVSSNNDSGASTPIPLPIKEPPLESNA- 138

  Fly   119 WKDKKV---TPYLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSPEDLVPSVYLSINQLAPAY 180
             ::.|:   ..:..:.:.|..||.|..||::||.:..:|..::...|.||:..||||||:|.|.|
pombe   139 -RNDKLKGHATFAEMVKAFTKIENTSKRLEIIDIMGTYFFGILRDHPSDLLACVYLSINKLGPDY 202

  Fly   181 EGLELGVAETTLMKAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQRMMFQPAPLNVRDVFRK 245
            .|||||:.|:.:||||.::||:.|..||......||||:||:.||.:|..||:||.|.:..:|..
pombe   203 SGLELGIGESIIMKAIGESTGQTLQQIKLSFHKVGDLGLVAQTSRQNQPTMFKPAALTIPFLFDS 267

  Fly   246 LREIAKLSGQS----KMDLVYNMFVACRSSEARFFIRSLIGKLRIGIAEQSLLTALAIGLVKKNH 306
            |::||::||..    |:.::..:..:|..:|.::.||:|.||||:.:||:::|.||| ....:.|
pombe   268 LKKIAQMSGNQSQNRKIGVIKRLLSSCEGAEPKYLIRALEGKLRLQLAEKTILVALA-NATAQYH 331

  Fly   307 IDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKYDIKELQERCPMHPGMPLRPML 371
            .|. ...|:.   :.:.::...:|:..|||.|:||:|:|.::::.:..|:|.|.:.||:|.:|||
pombe   332 ADK-NGEKLS---QQDRIEGEQILRDVYCQLPSYDLIVPHLIEHGLGTLRETCKLTPGIPTKPML 392

  Fly   372 AQPTKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIFSRNSENNTAKYPDLIARSTALL 436
            |:|||.:.||...|.....|||:||||||||:|..|.|:..:|||||||.:.:|||:....:...
pombe   393 AKPTKQISEVLNTFDQAAFTCEYKYDGERAQVHFTEDGKFYVFSRNSENMSVRYPDISVSVSKWK 457

  Fly   437 KGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKVQVCVYIFDLLYINGTALVTKN 501
            |.|.:|:|:|.|.|.||.:..:|||||.|:|||||:|.|.:|||:.|::.||:||:||..|:...
pombe   458 KPDARSFILDCEAVGWDRDENKILPFQKLATRKRKDVKIGDIKVRACLFAFDILYLNGQPLLETP 522

  Fly   502 LSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVKTLD-EEATYEIAKR 565
            |:||||||...||...|::.||...|...|:.:::|||||:|.:|||||||.|: .::.||.:||
pombe   523 LNERRKLLYSMFQPSTGDFTFAKHSDQKSIESIEEFLEESVKDSCEGLMVKMLEGPDSHYEPSKR 587

  Fly   566 SRNWLKLKKDYLSNVGDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENEEYQSICKIGTGFTDE 630
            ||:|||:||||||.|||||||:|||.|.|||:||..||.|||.|||.:.|..|||||:||||::|
pombe   588 SRHWLKVKKDYLSGVGDSLDLIVIGAYYGKGKRTSVYGAFLLGCYDPDTETVQSICKLGTGFSEE 652

  Fly   631 DLQTHSEFLGKHVTSAAKSYYRYD--PSLEPDHWFEPVQVWEVKCADLSLSPIHRAAIGIVDGER 693
            .|:|....|...|.|..|.:|.:.  |:.:||.||||..:|||..|||||||:::||||.|..::
pombe   653 HLETFYNQLKDIVISKKKDFYAHSDVPAHQPDVWFEPKYLWEVLAADLSLSPVYKAAIGYVQEDK 717

  Fly   694 GISLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNNQKSST 738
            |||||||||||||:||:.|:||.:.||:..|:||......:|..:
pombe   718 GISLRFPRFIRIREDKSWEDATTSEQVSEFYRSQVAYSQKEKEGS 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	320/760 (42%)
		DNA_ligase_A_N	126..292	CDD:282522	68/169 (40%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	110/218 (50%)
		OBF_DNA_ligase_I	581..726	CDD:153438	84/146 (58%)
cdc17	NP_593318.2	PLN03113	20..751	CDD:215584	317/747 (42%)
		DNA_ligase_A_N	149..319	CDD:282522	68/169 (40%)
		Adenylation_DNA_ligase_I_Euk	379..598	CDD:185710	110/218 (50%)
		OBF_DNA_ligase_I	603..750	CDD:153438	84/146 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	216	1.000	Domainoid score	I579
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H197
Inparanoid	1	1.050	575	1.000	Inparanoid score	I174
OMA	1	1.010	-	-		QHG56362
OrthoFinder	1	1.000	-	-		FOG0002684
OrthoInspector	1	1.000	-	-		oto101409
orthoMCL	1	0.900	-	-		OOG6_100906
Panther	1	1.100	-	-	LDO	PTHR45674
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2092
SonicParanoid	1	1.000	-	-		X2056
TreeFam	1	0.960	-	-
	14	13.860