DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig1 and lig-1

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_741625.2	Gene:	lig-1 / 179502	WormBaseID:	WBGene00002985	Length:	773	Species:	Caenorhabditis elegans

Alignment Length:	642	Identity:	324/642 - (50%)
Similarity:	438/642 - (68%)	Gaps:	29/642 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 WKDKKVTPYLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSPEDLVPSVYLSINQLAPAYEGL 183
            |......||...|.|.:.|||..|: |.:|.|:.||..|:..||:||...||:|:|||.|:||||
Worm    13 WAKGSKVPYKEFALTLEKIEELSGK-KKVDELAQFFTKVLDFSPDDLTACVYMSVNQLGPSYEGL 76

  Fly   184 ELGVAETTLMKAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQRMMFQPAPLNVRDVFRKLRE 248
            ||||||.:|:||:.|||||....||...:..||||.||:|||.:|:|:..|..|.|..||.||.|
Worm    77 ELGVAENSLIKAVAKATGRTEGKIKEDLRAKGDLGTVAQQSRSNQKMLAVPKALTVPTVFNKLTE 141

  Fly   249 IAKLSGQS----KMDLVYNMFVACRSSEARFFIRSLIGKLRIGIAEQSLLTALAIGL-------- 301
            ||||||.|    |:|.:..:.:||:..||||.:|.|.||:|||:.|||:|:||....
Worm   142 IAKLSGTSAMNKKVDAISALLIACQGIEARFLVRMLAGKMRIGLGEQSVLSALGHAFTLSKITDQ 206

  Fly   302 -VKKNHIDDCKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKYDIKELQERCPMHPGM 365
             |:.:.:|..|.:.|..|            |||||:||||:.:|...|...::.|.|:|.:.||:
Worm   207 KVRGDKLDSLKDANVKRV------------KTAYCECPNYNRLIEVALTEGVEALVEKCKLSPGI 259

  Fly   366 PLRPMLAQPTKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIFSRNSENNTAKYPDLIA 430
            ||:||||.||||:.|:..||....:||||||||||.|||:.|.|:|.|:|||.||||.||||:|.
Worm   260 PLKPMLAHPTKGIDEIMRRFRNQTMTCEWKYDGERGQIHKREDGQIFIYSRNQENNTTKYPDIIE 324

  Fly   431 RSTALLKGDVKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKVQVCVYIFDLLYINGT 495
            :.::.:...|.|:|:|:|:||.| |...||||||||||||||. .::..|:|.|::|||||.||.
Worm   325 KISSCIGDGVTSFIVDAEVVAID-EAGLILPFQVLSTRKRKNA-TDDNGVKVVVFLFDLLYFNGE 387

  Fly   496 ALVTKNLSERRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVKTLDEEATY 560
            .||.|.|.:||:||..:|::::|.:.|||::||||.||:..|.:|:::..|||||:||||.||||
Worm   388 PLVRKPLRKRRELLRTNFKKIDGSFYFATSVDTNDTDEINSFFDEAVQNKCEGLMIKTLDTEATY 452

  Fly   561 EIAKRSRNWLKLKKDYLSNVGDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENEEYQSICKIGT 625
            ||::||.:|||:||||:..|||:|||||:|.|.|.|:|||.|||:||.||:...|||:|:|||||
Worm   453 EISRRSHSWLKMKKDYVDGVGDTLDLVVMGAYSGVGKRTGVYGGYLLGCYNPTTEEYESVCKIGT 517

  Fly   626 GFTDEDLQTHSEFLGKHVTSAAKSYYRYDPSLEPDHWFEPVQVWEVKCADLSLSPIHRAAIGIVD 690
            |||||||....:.|.......:.|||::|.:|:||..|.|..|:||||||:::||.|:||.|:.|
Worm   518 GFTDEDLAEQYKILQDKKIDKSPSYYQFDHTLKPDDTFSPYLVFEVKCADITISPRHKAASGLTD 582

  Fly   691 GERGISLRFPRFIRIRDDKNSENATDANQVAHMYQSQDQVKNNQ-KSSTQMEMEDEF 746
            ..:|||||||||:||||||||::||.:.||..||::|:...|.: :.:..::.:|||
Worm   583 DGKGISLRFPRFLRIRDDKNSDDATSSEQVLEMYKNQEAFANQKIEKADAVDEDDEF 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	321/639 (50%)
		DNA_ligase_A_N	126..292	CDD:282522	87/169 (51%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	121/217 (56%)
		OBF_DNA_ligase_I	581..726	CDD:153438	84/144 (58%)
lig-1	NP_741625.2	DNA_ligase_A_N	20..190	CDD:282522	88/170 (52%)
		dnl1	77..617	CDD:273147	288/553 (52%)
		Adenylation_DNA_ligase_I_Euk	252..468	CDD:185710	121/217 (56%)
		OBF_DNA_ligase_I	473..618	CDD:153438	84/144 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165277
Domainoid	1	1.000	241	1.000	Domainoid score	I1253
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H197
Inparanoid	1	1.050	640	1.000	Inparanoid score	I445
Isobase	1	0.950	-	0	Normalized mean entropy	S1058
OMA	1	1.010	-	-		QHG56362
OrthoDB	1	1.010	-	-		D182401at33208
OrthoFinder	1	1.000	-	-		FOG0002684
OrthoInspector	1	1.000	-	-		oto20076
orthoMCL	1	0.900	-	-		OOG6_100906
Panther	1	1.100	-	-	LDO	PTHR45674
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2092
SonicParanoid	1	1.000	-	-		X2056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.890