DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNAlig1 and Lig1

DIOPT Version :9

Sequence 1:	NP_611843.2	Gene:	DNAlig1 / 37791	FlyBaseID:	FBgn0262619	Length:	747	Species:	Drosophila melanogaster
Sequence 2:	NP_001076657.2	Gene:	Lig1 / 16881	MGIID:	101789	Length:	916	Species:	Mus musculus

Alignment Length:	760	Identity:	380/760 - (50%)
Similarity:	511/760 - (67%)	Gaps:	42/760 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KKKSDATDSPSPPKKVPKIDAKTELPDEPHIKSESASPETKPKVEPMSVDSEEKTSPVKN----- 69
            :|:.|....||.|.|.|:....|:..:.|..|   |..:.||:.|      |:...|.:.
Mouse   173 EKEGDQLIVPSEPTKSPESVTLTKTENIPVCK---AGVKLKPQEE------EQSKPPARGAKTLS 228

  Fly    70 ---------VKKEPKEVDDKTTDKKVTTIGLNSTAATKEDVENYDPSADSYHPLKNAYWKDKKVT 125
                     ||.|.|:.:..|..|:.|...|        |..||:||.::|||:::|.||..:..
Mouse   229 SFFTPRKPAVKTEVKQEESGTLRKEETKGTL--------DPANYNPSKNNYHPIEDACWKHGQKV 285

  Fly   126 PYLALARTFQVIEETKGRLKMIDTLSNFFCSVMLVSPEDLVPSVYLSINQLAPAYEGLELGVAET 190
            |:||:||||:.|||...||||::||||...||:.:||.||:|.:|||:|:|.|..:||||||.:.
Mouse   286 PFLAVARTFEKIEEVSARLKMVETLSNLLRSVVALSPPDLLPVLYLSLNRLGPPQQGLELGVGDG 350

  Fly   191 TLMKAICKATGRNLAHIKSQTQLTGDLGIVAEQSRVSQRMMFQPAPLNVRDVFRKLREIAKLSGQ 255
            .|:||:.:||||.|..|:::....||:|:|||.||.:||:|..|.||.:..||.|..:||:|:|.
Mouse   351 VLLKAVAQATGRQLESIRAEVAEKGDVGLVAENSRSTQRLMLPPPPLTISGVFTKFCDIARLTGS 415

  Fly   256 S----KMDLVYNMFVACRSSEARFFIRSLIGKLRIGIAEQSLLTAL--AIGLVKKNH-----IDD 309
            :    |||::..:|||||.||||:..|||.|:||:|:||||:|.||  |:.|.....     :.|
Mouse   416 ASMAKKMDIIKGLFVACRHSEARYIARSLSGRLRLGLAEQSVLAALAQAVSLTPPGQEFPTAVVD 480

  Fly   310 CKASKVPDVYKDEIVDTTLLLKTAYCQCPNYDIIIPAILKYDIKELQERCPMHPGMPLRPMLAQP 374
            ....|..:..|..:.:..::||..:|:.|:.|.|||.:|::.::.|.|.|.:.||:||:||||.|
Mouse   481 AGKGKTAEARKMWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGVPLKPMLAHP 545

  Fly   375 TKGVHEVFERFGGMQITCEWKYDGERAQIHRNEKGEISIFSRNSENNTAKYPDLIARSTALLKGD 439
            |:||.||.:||..:..|||:||||:|||||..|.||:.|||||.|:||.||||:|:|...:....
Mouse   546 TRGVSEVLKRFEEVDFTCEYKYDGQRAQIHVLEGGEVKIFSRNQEDNTGKYPDIISRIPKIKHPS 610

  Fly   440 VKSYIIDSEIVAWDVERKQILPFQVLSTRKRKNVDIEEIKVQVCVYIFDLLYINGTALVTKNLSE 504
            |.|:|:|:|.||||.|:|||.|||||:|||||.||..||:||||:|.|||:|:||.:||.:.||.
Mouse   611 VTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVRQPLSR 675

  Fly   505 RRKLLLEHFQEVEGEWKFATALDTNDIDEVQQFLEESIKGNCEGLMVKTLDEEATYEIAKRSRNW 569
            ||:||.|:|.|.|||:.|.|:|||.|.:::.:|||:|:|.:||||||||||.:|||||||||.||
Mouse   676 RRQLLRENFVETEGEFVFTTSLDTKDTEQIAEFLEQSVKDSCEGLMVKTLDVDATYEIAKRSHNW 740

  Fly   570 LKLKKDYLSNVGDSLDLVVIGGYKGKGRRTGTYGGFLLACYDTENEEYQSICKIGTGFTDEDLQT 634
            ||||||||..|||:|||||||.|.|:|:|.|.|||||||.||.|:||.|:|||:||||:||:|:.
Mouse   741 LKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLLAAYDEESEELQAICKLGTGFSDEELEE 805

  Fly   635 HSEFLGKHVTSAAKSYYRYDPSLEPDHWFEPVQVWEVKCADLSLSPIHRAAIGIVDGERGISLRF 699
            |.:.|...|....:.|.|.|.::.||||.:|..||||||||||||||:.||.|:||.|:||||||
Mouse   806 HHQSLQALVLPTPRPYVRIDGAVAPDHWLDPSIVWEVKCADLSLSPIYPAARGLVDKEKGISLRF 870

  Fly   700 PRFIRIRDDKNSENATDANQVAHMYQSQDQVKNNQKSSTQMEMED 744
            |||||:|.||..|.||.:||||.:|:.|.|::|.|.|....::||
Mouse   871 PRFIRVRKDKQPEQATTSNQVASLYRKQSQIQNQQSSDLDSDVED 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNAlig1	NP_611843.2	PLN03113	1..745	CDD:215584	380/760 (50%)
		DNA_ligase_A_N	126..292	CDD:282522	88/169 (52%)
		Adenylation_DNA_ligase_I_Euk	358..576	CDD:185710	135/217 (62%)
		OBF_DNA_ligase_I	581..726	CDD:153438	90/144 (63%)
Lig1	NP_001076657.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..197		8/23 (35%)
		PLN03113	171..912	CDD:215584	378/755 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	236..266		11/37 (30%)
		Interaction with target DNA. /evidence=ECO:0000250	447..456		5/8 (63%)
		Interaction with target DNA. /evidence=ECO:0000250	640..642		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	879..916		17/37 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847477
Domainoid	1	1.000	269	1.000	Domainoid score	I1841
eggNOG	1	0.900	-	-		E1_COG1793
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H197
Inparanoid	1	1.050	733	1.000	Inparanoid score	I606
Isobase	1	0.950	-	0	Normalized mean entropy	S1058
OMA	1	1.010	-	-		QHG56362
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002684
OrthoInspector	1	1.000	-	-		oto93864
orthoMCL	1	0.900	-	-		OOG6_100906
Panther	1	1.100	-	-	LDO	PTHR45674
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2092
SonicParanoid	1	1.000	-	-		X2056
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740